Liposomal Curcumin Review, Benefits & Uses

Liposomal curcumin is any type of curcumin supplement that has been encapsulated in a liposome. A liposome is a type of tiny vesicle with a phospholipid outer layer, used to improve the fat solubility of dietary ingredients.

This is done to improve absorption and systemic bioavailability of curcumin extract. Research shows that liposomal delivery of therapeutic substances increases bioavailability by as much as 1500%.

Curcumin is the bioactive constituent in turmeric (curcuma longa). Curucmin is associated with a number of health benefits, including improved protection from oxidative damage, a reduction in inflammation and improved joint functionality.

Curcumin supplements are widely used, but many are poorly absorbed in humans after ingestion. The use of a liposomal curcumin liquid or capsule can improve absorption, allowing the consumer to take a smaller dosage to derive beneficial effects.

According to the manufacturers of one liposomal turmeric extract, this supplement supports antioxidant activities, the elimination of toxins, immune function, healthy aging and healthy cholesterol levels.

Curcumin

Anti-Inflammatory

Joints

Health

Anti- Aging

How It Works:

• Effective anti-inflammatory supplement
• Shown to improve joint functionality
• Anti-oxidant to supper general health

Dosage:

Between 1 - 3 g per day

Safety:

Rated Likely Safe

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What are Liposomes?

A liposome is a spherical sac containing at least one phospholipid bilayer. Liposomes are used to deliver various medicines and nutrients.

Liposomes result from altering the structures of biological membranes; normally via sonication (exposure to sound energy).

Research supports using liposomal delivery for certain medication types. This delivery method is effective for minimizing toxicity potentials and enhancing medication efficacy.

Liposomal delivery is particularly useful for medications with narrow therapeutic indices that require carrier agents. Carrier drugs are capable of altering the pharmacokinetics and biodistribution of given medicines.

Some of the benefits of liposomal delivery include:

• Selectively passive targeting of immunity cells;
• Improved lipophilic and amphiphilic solubility;
• Increased penetration of targeted tissues;
• Increased hydrophilic molecule transfer;
• Sustained local and systemic release;

Liposomal delivery of medicinal agents allows more of the medicinal substances to reach targeted tissues.

This is accomplished with minimal degradation of pure substances. In many cases, the necessary dose of a given substance is decreased by between 10 and 15 times because of liposomal delivery.

Liposomal Curcumin Benefits

Curcumin is a strong antioxidant and anti-inflammatory agent. It also demonstrates anticancer, antidiabetic, cardioprotective, antibacterial, antiviral, immunomodulatory and neuroprotective potentials in research studies.

The antioxidant effects of curcumin protect DNA and cell membranes from damages that can lead to disease. Preliminary research has examined the effects of curcumin on cancer development and progression. In in vitro and in vivo studies, it has demonstrated effects against breast, colon, skin and prostate cancer.

Some human research suggests that curcumin can improve plasma lipid balance. It may help to decrease low density lipoprotein (LDL) cholesterol, total cholesterol and triglycerides. It may also help to elevate HDL (good) cholesterol.

By decreasing serum cholesterol and triglycerides, liposomal curcumin is believed by some medical experts to reduce the risks of atherosclerosis, the leading cause of coronary artery disease and heart disease.

However, more research studies are needed to validate this claim. It has not been approved by the FDA for the prevention or treatment of heart disease.

Liposomal curcumin administration may also help to reduce the formation of amyloid plaque that has been linked to Alzheimer’s disease. It has also been researched for its effects on Parkinson’s disease, dementia and other neurodegenerative disorders.

Uses for Liposomal Curcumin

There has been a lot of progress in liposomal drug delivery research recently. It is especially useful at increasing aqueous solubility and systemic bioavailability of certain substances with poor absorption, like curcumin.

Curcumin is used for a wide range of health-enhancing purposes. The Natural Medicines Comprehensive Database states the following curcumun uses:

• Systemic lupus erythematosus (SLE)
• Rheumatoid arthritis (RA);
• Irritable bowel syndrome;
• Alzheimer’s disease;
• Kidney inflammation;
• Loss of appetite;
• Peptic ulcers;

Turmeric and curcumin are also used for headaches, fatigue, bronchitis, hyperlipidemia, parasitic worms and tuberculosis. However, it has not been approved by the FDA for the treatment of any specific medical conditions.

Liposomal Curcumin and Pancreatic Cancer

Research shows that liposomal curcumin inhibits cellular proliferation and suppresses growth in human MiaPaCa pancreatic tumor cells. These effects occurred in both xenograft and in vitro studies.

Xenografted tumors in nude mice were suppressed by at least 42% within 4 weeks with daily administration.

Liposomal Curcumin Side Effects

There are no serious or permanent adverse effects associated with proper curcumin usage. It demonstrates very low toxicity and high tolerability in most healthy people.

In rare cases, nausea, vomiting, bloating, diarrhea and/or stomach discomfort result from usage. These symptoms pass on their own quickly in most cases.

Liposomal Curcumin Interactions

Certain disease, drug, herb and supplement interactions are possible. You should be cautious if using liposomal curcumin in conjunction with antiplatelet, anticoagulant and/or antidiabetic medications or herbs.

Liposomal curcumin may also interact adversely with P-glycorpotein substartes, P450 cytochrome substrates, norfloxacin, sulfasalazine, pacitaxel, docetaxel and talinolol.

If you have an iron deficiency, then talk to your doctor before taking liposomal curcumin. It may bind with iron and suppress its absorption.

Seek medical advice before beginning to use liposomal curcumin products if you have a hormone-sensitive cancer, heart disease, diabetes mellitus, gallbladder obstruction or bile duct disorder.

Conclusions

Curcumin is believed to be a multi-therapeutic substance that causes very few adverse side effects in the majority of users. Traditional use for thousands of years has also demonstrated its general safety.

If you are considering using a liposomal curcumin supplement, then ensure that you choose a supplement with an established reputation for quality and efficacy. Always follow manufacturer’s dosing recommendations carefully and self-monitor for adverse side effects.

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