Longvida Optimised Curcumin is a dietary supplement that contains 500mg of high-absorption free-form curcumin per serving. According to the manufacturer, this supplement is 285x more bioavailable than standard forms of this ingredient and has 7x longer-lasting action.
This product is used primarily to support cognitive health.Longvida curcumin supplements are specially formulated to cross the BBB (blood brain barrier) efficiently and rapidly.
Curcumin is the bioactive molecule in turmeric, a rhizomatous plant that has been used in traditional medicine for thousands of years. It has demonstrated anti-oxidant and anti-inflammatory benefits in research studies.
When used as an oral supplement, a large percentage of curcumin gets broken down inside the stomach, making its absorption rate low. Supplements like of Longvida curcumin are formulated to increase the bioavailability of this active ingredient.
The makers of Longvida curcumin utilize a patented process which encapsulates the supplement to increase its absorption from the gastrointestinal tract. Longvida Optimized Curcumin can be purchased in supplements like CurcuBrain from NOW Foods.



- Effective anti-inflammatory supplement
- Shown to improve joint functionality
- Anti-oxidant to supper general health
Longvida Curcumin
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Longvida curcumin supplements were formulated by neuroscientists from UCLA. They call their specialized encapsulation technology SLCP – Solid Lipid Curcumin Particle Technology.
By encapsulating curcumin extract in lipids, this suppresses hydrolysis, or the molecular breakdown caused by reactions with water, which can occur after ingestion of the supplement.
It helps to keep the curcumin molecules from being degraded by acids in the stomach. This allows the curcumin to reach the gastrointestinal tract and be absorbed more effectively into the bloodstream.
Different formulations of curcumin supplements can affect the body and brain in different ways. That is because they contain different concentrations of the constituents which make up curcumin, called curcuminoids.
Some of the most well-known brands of curcumin products aside from Longvida include Sabinsa C3, Meriva and BCM 95.
According to research studies, Longvida curcumin capsules have up to 65 times the bioavailability of free curcuminoids found in many other dietary supplements.
Longvida Curcumin Benefits
Longvida Curcumin was developed to maximize curcumin’s capacities to support the growth and maturation of new nervous tissues (neurogenesis).
Curcumin has been shown to increase brain-derived neurotrophic factor (BDNF), a hormone synthesized in the brain which helps to protect against cognitive dysfunction and neurodegenerative diseases like Alzheimer’s.
Longvida curcumin also demonstrates anti-inflammatory and antioxidant properties which provide neuronal protection. Curcumin binds with amyloid-B protein fragments that can cause oxidative stress and chronic low-grade inflammation.
When amyloid protein fragments accumulate, they cause amyloid plaque to form between the neurons inside the brain. This is believed to be a main cause of Alzheimer’s disease.
Routine use of curcumin can inhibit amyloid plaque from forming, thereby helping to prevent neuronal degeneration and dysfunction.
Longvida curcumin works as an antioxidant which can pass the BBB and induce effects directly inside the brain.
This decreases damages that would result from radical agents like free radicals, reactive nitrogen species (RNS), reactive oxygen species (ROS), environmental toxins and other systemic pollutants.
Longvida Curcumin Effects on the Body
Longvida curcumin supplements also provide anti-inflammatory effects inside the brain and throughout the body.
By inhibiting and reducing low-grade systemic inflammation, it may help to reduce the risks for developing various adverse health conditions.
Verdure Sciences, Inc., the manufacturer of Longvida curcumin, claims that it is also helpful for maintaining healthy bones and joints.
It is also said to help to naturally balance lipid profiles; reducing LDL-C and elevating HDL-C. Regular usage may help to promote overall circulatory health.
Longvida curcumin supplements do not contain any turmeric oils. They are 100% optimized curcumin.
Research has shown optimized Longvida curcumin to be siginificantly more biologically effective than certain other curcunmin supplements. Human studies have shown it to be more than 60 times as absorbable than non-optimized curcumin.
Safety of Longvida Curcumin
Turmeric and curcumin are known to likely safe when used properly in most healthy adults and children. It can be taken orally or applied topically. Curcumin is rated as possibly safe for short-term usage in enemas.
It is also rated as likely safe for use during lactation and pregnancy, as long as amounts are kept consistent with amounts commonly gained from the average diet.
Longvida curcumin may interact with various medications, including:
- Antiplatelet/anticoagulant drugs;
- Antidiabetes medications;
- Cytochrome P450 1A1, 1A2 and 3A4 substrates;
- Docetaxel;
- Estrogen;
- Norfloxacin;
- Paclitaxel;
- P-glycoprotein substrates;
- Sulfasalazine;
- Taninolol;
If you are considering using Longvida curcumin, or products which contain it, and you take prescription medications, then it is best to speak with a doctor first.
Be careful stacking curcumin supplements with herbs including ginseng, willow, clove, garlic, red clover, angelica, dashen, gingko, devil’s claw, guar gum, fenugreek, horse chestnut and/or psyllium.
High doses of curcumin may also decrease the absorption of iron.
Longvida Curcumin Side Effects
Turmeric and curcumin are well-tolerated in most users when taken properly. Some temporary side effects have been reported; including vomiting, nausea, diarrhea, dyspepsia (heartburn), bloating and/or gastroesophageal reflux.
In a single case, one patient taking high doses of a product containing curcumin was affected by atrioventricular heart blockage. This patient had used 1500-2250 mg doses of a supplement containing turmeric daily for one month before the condition presented.
The product taken was a multi-ingredient supplement. It is not known if turmeric caused the heart blockage, or another ingredient, or a contaminant.
Turmeric and curcumin may also cause contact dermatitis in some who use them topically.
Conclusions
Much research is being directed at the anti-inflammatory and antioxidant effects of turmeric and curcumin.
Curcumin is a natural substance which may reduce risk factors for health conditions; including type 2 diabetes mellitus, cardiovascular disease, cancer and obesity.
Longvida curcumin supplements, like all quality curcumin supplements are associated with multiple therapeutic potentials.
However, Curcumin SLCP, Longvida® is marketed primarily as a neuroprotectant. It is manufactured to maximize its stability, solubility and absorption.
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Article last updated on: April 5th, 2018 by Nootriment
3 Comments
hello whats the safe number of longvida curcumin capsules you can take a day and does it reach the blood brain barrier if you break open the capsule and pour the curcumin in a drink of food?
My apologies as I don’t know the answer. I see no other avenue in which to ask a question therefore this will appear as a response to the question you asked. I am extremely confused about this product, which is not inexpensive, because it does not contain Black Pepper extract explained as needed in everything you read about Curcumin; copied and pasted the following regarding this:
“It has a poor oral bioavailability (a low percentage of what you consume is absorbed) and thus should be enhanced with other agents such as black pepper extract, called piperine. This is unless you want the curcumin in your colon (as it is a colon anti-inflammatory and can help with digestion), in which case you wouldn’t pair it with an enhancement.”
I can’t believe the vast majority of people taking CURCUMIN, WHICH SPECIFICALLY CROSSES THE BBB, is taking Longvida™ for colon anti-inflammatory benefits. Can anyone please help me with this???
The reason why the curcumin is encapsulated with a special process, is unique. It isn’t even the same as curcumin in the form of phytosomes. They are similiar, but yet different. Yes, you’re right about the low bioavailability of curcumin in general and all the additives help with this, but the ‘Longvida’ process is entirely unique, and it will cross the blood brain barrier, as the other ones won’t. This specific process also has a half-life of 7.5 hrs., as compared to 1.5 hrs, since it uses this process, and allow the curcumin to stay as a free-form. This free-form action causes it to be circulated in blood for much longer because of the free state. Free form means its not metabolized, and ready to be excreted through our urine. This is a big bonus, as well as the Blood brain barrier for those who are at a higher age and might suffer from alzheimers. Neuronal protectant is this type of curcumin. I hope I helped you some more. :)