5 Ways Meclofenoxate Improves Memory and Brain Health

Meclofenoxate is one of the trade names for the nootropic supplement Centrophenoxine, also marketed under the name Lucidril.

This cognitive enhancer is a compound of both dimethylaminoethanol (DMAE) and parachlorophenoxyacetate (pCPA).

It is regarded in many ways as a more effective version of DMAE and an excellent source of choline for your brain. Meclofenoxate also possesses significant anti-aging properties that can improve the health of your neurons and boost cellular function.

As a smart drug, it is reported to increase alertness, vigilance, information retention, memory recall, brain energy and nerve synapse repair. What are some of the effects of using Meclofenoxate supplements in your nootropic stack?

Centrophenoxine

Cholinergic Supplement

Brain Health

Memory

Neuro- plasticity

How It Works:

• Supports memory & heightens acetylcholine
• May reduce lipofuscin & beta-amyloid residue
• Boosts brain health & fights aging

Dosage:

Between 250 - 1,500mg per day

Safety:

Generally Well Tolerated

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1. High Quality Source of Choline

Choline is a nutrient vital to brain function, but as much as 90% of the population is deficient in this recently named B Vitamin.

Normally, choline flows from your circulating blood to the brain, but if levels of this nutrient are too low, it is actually removed from the brain and transported back into the bloodstream for use elsewhere in the body.

You will find Choline in foods like eggs, liver, and other meats as well as in dietary supplements such as Choline Chloride or Choline Bitartrate.

However, the choline found in these supplements has poor bioavailability and is 60% broken down in the gut. Meclofenoxate is a much higher quality Choline supplement with better absorption into the blood.

This is because it contains DMAE which is not digested by bacteria in the gut. Your liver can also easily convert DMAE into choline, resulting in a much greater net increase in choline supply to the brain.

2. Increases Acetylcholine Levels

Once Choline reaches your brain, it can be used as phosphatidylcholine and incorporated into your brain cell membranes or it can be converted into the neurotransmitter acetylcholine.

Acetylcholine is one of the most important neurotransmitters for functions related to memory, focus and reasoning. It is involved in memory storage processes as well as conversion from short-term to long-term memory and memory retrieval.

Higher levels of acetylcholine are associated with improved information retention, learning and synaptic plasticity. Lower levels of this neurotransmitter are associated with memory loss, cognitive decline, senile dementia and Alzheimer’s.

As one of the best sources of Choline, Meclofenoxate is also a highly effective precursor to acetylcholine. This neurochemical is synthesized in the brain by combining acetate and choline. But if there is not enough of it in your blood to keep up with the constant demand from your synapses, your neurons start to break down the phosphatidylcholine in their cell membranes to produce this neurotransmitter.

This is known as auto-cannibalization and while this process ensures that your choline needs are temporarily met, it can damage the membrane fluidity of your neurons, leading to diminished cell function.

Meclofenoxate prevents this from happening by ensuring there is enough choline to make acetylcholine. Furthermore, by increasing synthesis of this neurotransmitter, Meclofenoxate can lead to cognitive enhancement and improved intellectual capacities above and beyond the baseline.

3. Lipofuscin Removal

Lipofuscin is a biochemical waste product that accumulates in your cells as you age. This accumulation happens throughout the body and is uniquely noticeable on the skin as brown “liver spots.”

While we cannot see the Lipofuscin build-up in our brain cells, it can amount to as much as 33% of the volume of your cells and over time diminishes healthy cellular function.

Animals with high levels of this residue experience impaired learning and memory abilities and may exhibit a faster rate of neuron death. Meclofenoxate has been shown to significantly reduce the amount of brain lipofuscin present, causing as much as a 42% decrease in just 8 weeks.

This can restore memory capacity back to normal and slow down the aging process that can lead to senile dementia and elderly cognitive decline.

4. Increases Cellular Energy

Your brain relies on oxygen and glucose to make energy and fuel its many neuronal functions. Meclofenoxate is known to increase the uptake of oxygen and glucose in neurons, leading to higher output of ATP which is the main energy source for your cells.

By boosting the brain’s metabolism, Meclofenoxate can cause a broad improvement in brain function and mental performance. This effect is particularly noticeable in terms of increased alertness, concentration, attention span, and even motivation.

5. Improves Cell Repair

Finally, Meclofenoxate has been shown to increase protein production and RNA levels in your neurons. This plays a role both in the anti-aging benefits of this nootropic as well as improving memory encoding.

RNA controls protein formation in your neurons and essentially transmits instructions from DNA to your cells.

These proteins are necessary for processes like cellular repair as well as storing new memories. Brain RNA levels are known to decline as we age – especially with lipofuscin accumulation present in the cells.

Meclofenoxate is observed to reverse this age-related decline, promoting better maintenance and repair of neurons and their synapses. This can improve the way your neurons communicate with each other and potentially even slow down the onset of degenerative disease such as Alzheimer’s.

How to Use Meclofenoxate

As you can see, the benefits of using Meclofenoxate supplements are profound and can lead to meaningful improvements in your cognitive function and mental performance.

Meclofenoxate can be purchased online as generic Centrophenoxine in either pill or powder format. The bulk powder versions are typically 3-5 times cheaper than capsule formulations and can be mixed into milk for easy consumption.

Young individuals will typically take 250 mg to 500 mg of Centrophenoxine per day while older people may need between 750 to 1500 mg per day for best results.

Note that the active ingredient in this nootropic drug is DMAE which is not appropriate for pregnant women to take. If you are currently pregnant or are trying to become pregnant, do not use this drug due to a risk of teratogenic effects.

Meclofenoxate is known to be even more effective when combined with Acetyl L-Carnitine supplements and also works well with the Racetam nootropics like the best-selling Piracetam.

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