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Modafinil has come to be known as the drug of choice for entrepreneurs, students and high-powered executives.
The reasons for the drug’s popularity are its capacity for providing the user with psychostimulating effects while increasing the user’s ability to focus. All of this occurs without producing the agitation or the crash typically associated with other stimulants.
Modafinil is considered non-addictive and has a low incidence of serious side effects. Users often report experiencing an increase in motivation, cognitive ability, and even more fluidity with their speech.
Articles have appeared in various media publications like Rolling Stone praising the effects of Modafinil and even comparing it to the Limitless drug NZT-48. If you want to use this drug, where can you find Modafinil online to order?
Alertness
Mental Acuity
Focus- Stimulates wakefulness in the brain
- Promotes mental acuity & processing
- Enhances focus, motivation & energy
Ordering Modafinil Online
Related Topics
- What is Modafinil? (Provigil)
- How Does Provigil Work?
- Effects and Benefits
- User Reviews
- Typical Experiences
- Recommended Dosages
- How to Take
- Provigil Uses
- Use for ADHD
- Effects on Weight Loss
- Negative Side Effects
- Abuse Warnings & Dangers
- Comparison to Adrafinil
- Comparison to Armodafinil
- Comparison to Adderall
- Where to Buy
- Generic Modafinil Brands
- Is Modafinil Legal?
- How to Get Modafinil
- Review of Online Sources
Modafinil is a prescription drug in most countries including the USA, the UK, Canada, and Australia.
Two prominent countries which sell it over the counter without a prescription are Mexico and India.
Retailers residing in both countries offer generic Modafinil online to international buyers, though it can be difficult to determine the level of quality.
Is it safe to buy Modafinil online? Where do you find it? And how can you know if it is legitimate of not?
History and Traditional Uses of Modafinil
It is easier to understand how the prescription or non-prescription regulations work with regards to Modafinil by first understanding its origins.
In 1974, researchers at the pharmaceutical company Lafon Laboratories in France developed a group of benzhydryl sulfinyl compounds. One of these compounds was Adrafinil, a eugeroic drug (wakefulness promoting agent). In animal research, Adrafinil was seen to increase alertness and activity. Unline amphetamine stimulants that typically increase anxiety, the increase in locomotion in animal studies is believed to be due to wakefulness, hence the classification as a eugeroic.
In research done to determine the mechanism of action of Adrafinil, it was discovered that the primary active metabolite of the drug is Modafinil. Adrafinil, when taken into the body, is metabolized in the liver into Modafinil, and the inactive modafinilic acid.
The same company continued working on the drug and eventually were able to synthesize Modafinil directly, thereby eliminating the need for the original substance, Adrafinil. Modafinil was patented and brought to market in the late 1990s under various names such as Provigil, Alertec and Modavigil.
As was to be expected from the previous research with Adrafinil, initial research studies using Modafinil in animals showed increased activity and wakefulness. Consequently, the first studies using Modafinil in humans were for improving the sleep disorder narcolepsy.
Narcolepsy is a sleep disorder that affects sleep and wakefulness. People with this condition experience persistent excessive daytime sleepiness that is not related to sleep deprivation. Additional symptoms may include falling asleep instantly and randomly throughout the day; cataplexy, which is brief periods of extreme muscle weakness and subsequent bodily collapse brought on by strong emotions; sleep paralysis, which is the sensation of being paralyzed when falling asleep or when waking; vivid hallucinations upon waking; and altered nighttime sleep patterns.
In multiple double-blind placebo-controlled clinical research studies, Modafinil has significantly increased wakefulness and reduced daytime sleepiness in patients with narcolepsy compared to a placebo. When comparing Modafinil to a placebo, scores on the Multiple Sleep Latency Test and the Maintenance of Wakefulness Test are both improved in patients who were given Modafinil.
Modafinil has also been studied in combination with other narcolepsy medications, specifically sodium oxybate. In one phase 3, randomized, placebo-controlled research study done on Modafinil and sodium oxybate both individually and in conjunction, the scientists determined that both of the active medications significantly improved scores on the Epsworth Sleepiness Scale, Maintenance of Wakefulness test, and the Clinical Global Impression of Change test compared to placebo. The researchers further concluded that the two medications in conjunction may be more effective than either medication alone.
Narcolepsy is the first sleep disorder that Modafinil was approved for. Since that time it has been approved for more sleep disorders, specifically shift-work sleep disorder and obstructive sleep apnea/hypopnea syndrome.
Shift-work sleep disorder is a circadian rhythm disorder that can occur when people need to shift their sleep schedules due to working late or overnight shifts. The people experience excessive sleepiness when they are awake working their shifts during non-standard awake hours (nighttime), and can experience insomnia when trying to sleep during non-standard sleep hours (daytime). This disorder is also seen sometimes in people who work excessively long shifts, such as some doctors and nurses.
In various double-blind placebo-controlled studies, Modafinil has been seen to improve wakefulness and reduce excessive sleepiness in people with shift-work sleep disorder significantly over placebo. In one study, people were given a dose of Modafinil or a placebo before a work shift; the people who took Modafinil had a reduction in the frequency and duration of attention lapses measured by the Psychomotor Vigilance test compared to placebo patients.
Modafinil has also been used as an adjunct therapy for people with sleep apnea/hypopnea. In patients with this condition, during sleep the muscles of the mouth relax, allowing the tongue and/or soft palate to move backwards and either partially or completely block the airway. This leads to either shallow labored breathing during partial blockage (hypopnea), or the cessation of breathing during total blockage (apnea).
Because sleep quality can be greatly diminished due to waking up multiple times during the night when breathing is impaired, many people with apnea or hypopnea experience excessive daytime sleepiness. Despite using the primary treatment of continuous positive airway pressure therapy to address the apnea/hypopnea, some patients still report having residual sleepiness. In a research study, it was found that a significantly higher percentage of patients who took Modafinil had normalized sleepiness ratings compared to placebo patients.
Due to its well documented wakefulness-promoting effects, Modafinil has been approved by the FDA for use as a prescription drug for narcolepsy, shift-work sleep disorder, and obstructive sleep apnea/hypopnea.
- Increases energy, wakefulness and motivation
- Boosts mental performance and focus
- Supports memory and cognition
Common Off-Label Uses of Modafinil
Over the history of its use as a prescription medication, there have been many conditions outside of approved uses that people have taken Modafinil for. Any use outside of the previously mentioned sleep disorders is currently considered an off-label use.
Some of these uses have been due to the wakefulness-promoting effects of Modafinil. Fatigue is a symptom commonly associated with various conditions including depression, multiple sclerosis (MS), and Parkinson’s disease. There has been some limited research done on using Modafinil for fatigue in these conditions. As has been seen in research on narcolepsy, shift-work sleep disorder, and sleep apnea, wakefulness has been seen to increase in patients with disease related fatigue.
Due to its stimulant-like effects Modafinil has been used as a concentration, focus, and memory treatment for people with attention-deficit disorder (ADD) and attention-deficit hyperactivity disorder (ADHD). This is considered to be the most common off-label prescription use of Modafinil.
Multiple double-blind research studies have tested using Modafinil to manage ADHD in adults. Some studies compared Modafinil to a placebo, while others compared both Modafinil and conventional medications to placebo.
One double-blind placebo-controlled three phase crossover study compared the effectiveness of Modafinil to both a conventional ADHD drug (dextroamphetamine) and to a placebo. It was found that compared to patients who received a placebo, patients who were given either of the two active medications had significantly betters scores on the DSM-IV ADHD Checklist. Due to its ability to produce results similar to a traditionally prescribed medication, the researchers suggested that Modafinil may be a viable alternative to conventional stimulants for the treatment of adults with ADHD.
Other studies have compared Modafinil to a placebo alone, and found that scores on various tests including the Attention-Deficit/Hyperactivity Disorder Rating Scale-IV School and Home Versions, the Clinical Global Impressions Improvement scale, and the Teacher and Parent ADHD Rating Scale-IV are all significantly improved using Modafinil over a placebo.
While Modafinil has still not been officially approved as a treatment for reducing fatigue in various conditions, and as a treatment for ADD/ADHD, there are many doctors who are informed of current research that will prescribe this drug for these purposes. These prescriptions are entirely legal, however they are up to individual doctor’s discretion if they want to write them.
Adrafinil vs Modafinil vs Armodafinil
As previously mentioned, Adrafinil is a drug that breaks down in the body into Modafinil. This makes Adrafinil a prodrug of Modafinil. Unlike Modafinil, Adrafinil is an unregulated, unscheduled compound that can be bought without a prescription in many countries around the world. Many people will buy Adrafinil as a non-prescription alternative to Modafinil to use for many of the off-label uses of Modafinil.
In 2008, Cephalon’s (Lafon Laboratories was bought by Cephalon) patent for Provigil (the most popular brand name version of Modafinil) was scheduled to expire, so they modified Modafinil by using only the Right enantiomer (or isomer) and patented a new drug known as Armodafinil (literally “R”(ight)- Modafinil).
The practice of altering the chemical composition of a drug by eliminating one of the enantiomers isn’t necessarily uncommon, especially if only one enantiomer is responsible for the beneficial effects produced by the drug. In fact, sometimes, by doing so, researchers are able to rid the drug of certain adverse side effects.
Finding Modafinil Online
Once your doctor has issued a prescription for Modafinil, some countries permit you to import your drug from an online pharmacy. Some people will turn to using an online pharmacy over a traditional brick-and-mortar store due to costs. Even for prescribed uses, Modafinil is not always covered by all health insurance companies, and the cost of this medication from traditional stores can be very high.
Buying from an online pharmacy can be quite easy to do if you already have an online provider with whom you feel comfortable. For many individuals who do not, the search for a legitimate pharmacy or provider can be daunting.
Running a simple Google search for “where to find Modafinil online” produces so many results it is impossible to distinguish legitimate pharmacies from non-legitimate providers.
There are a few websites dedicated to user-shared nootropic information. The larger of these sites maintain lists of online retailers with whom users have consistently had positive or negative experiences.
Positive experiences include good prices, good customer service, fast shipping and quality products. Negative experiences include retailers who do not ship, or ship weeks after an order is placed, as well as sending low quality or impure products.
The website Reddit offers an active subreddit (a sub-forum) dedicated to nootropics information and user experiences. There, you can find a user-maintained list depicting “reliable” and “unreliable” online providers.
Another active and user-friendly site is Longecity. Longecity offers a forum dedicated to brain health where nootropics, including Modafinil, are regularly discussed and users commonly share their good and bad experiences and reviews with the various vendors.
Getting a Modafinil Prescription
Getting a Modafinil prescription may mean visiting a few different doctors before finding one who is familiar with both on-label and off-label uses of Modafinil. Even then, if you don’t have a documented on-label condition, many doctors will not prescribe Modafinil. There are a growing number of doctors that prescribe Modafinil for common off-label uses such as ADHD, but not all doctors will.
While many people will get their Modafinil prescription through their normal family or specialist doctor, there are some online pharmacies that offer online doctor prescription services. You will need to provide your past medical records and go through a consultation online to determine if you are eligible for a prescription.
While some Modafinil online UK pharmacies do appear to be registered pharmacies with the General Pharmaceutical Council, they only give online prescriptions to UK residents. Other online pharmacies from mainland Europe say that they will give online prescriptions for people from other countries. However, the legitimacy of some these online doctor prescriptions from other parts of Europe is suspect, and you will need to do your research and make sure you choose a reputable, legal source for your prescription.
The alternative to buying Modafinil online with a prescription is ordering without a prescription. This may prove unreliable and costly – you may be buying for less, but the risks of seizure at the border, shipping or non-shipment issues, as well as consuming something mislabeled and possibly toxic are potential hazards. It is also technically illegal to buy Modafinil without a prescription.
For people who cannot get a Modafinil prescription, and do not want to risk using an online pharmacy that does not require one, there are Modafinil alternatives. Adrafinil is widely available through nutritional supplement outlets and smart-drug websites. As the prodrug of Modafinil, many people will use this compound as a legal alternative.
In the US, Adrafinil is an unregulated, unscheduled compound that is legal to buy, own, and use. It is similarly unregulated in many other countries around the world. One note of caution, because of how it is broken down in the liver, it is hypothesized that Adrafinil can be damaging to the liver if used over the long-term, so it is best used occasionally.
Conclusion
Modafinil is available through online pharmacies for those with a prescription. When looking for where to buy Modafinil online, it is important to consult user reviews and past experiences with certain vendors to determine whether it is safe to order from a prospective retailer.
Not all suppliers are legitimate and there are no guarantees of quality when ordering this drug online. If you cannot find Modafinil for sale, Adrafinil is a solid non-prescription alternative to Modafinil and is widely available at reputable online smart drug providers.
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- Scoriels L, Jones PB, Sahakian BJ. Modafinil effects on cognition and emotion in schizophrenia and its neurochemical modulation in the brain. Neuropharmacology. 2013
- Chapman JL, Kempler L, Chang CL, Williams SC, Sivam S, Wong KK, Yee BJ, Grunstein RR, Marshall NS. Modafinil improves daytime sleepiness in patients with mild to moderate obstructive sleep apnoea not using standard treatments: a randomised placebo-controlled crossover trial. Thorax. 2014
- Minzenberg MJ, Gomes GC, Yoon JH, Watrous AJ, Geng J, Firl AJ, Carter CS. Modafinil augments oscillatory power in middle frequencies during rule selection. Psychophysiology. 2014
- Schmaal L, Goudriaan AE, Joos L, Dom G, Pattij T, van den Brink W, Veltman DJ. Neural substrates of impulsive decision making modulated by modafinil in alcohol-dependent patients. Psychol Med. 2014
- Artsy E, McCarthy DC, Hurwitz S, Pavlova MK, Dworetzky BA, Lee JW. Use of modafinil in patients with epilepsy. Epilepsy Behav. 2012
- Estrada A, Kelley AM, Webb CM, Athy JR, Crowley JS. Modafinil as a replacement for dextroamphetamine for sustaining alertness in military helicopter pilots. Aviat Space Environ Med. 2012
- Aagaard L, Hansen EH. Adverse drug reaction labelling for atomoxetine, methylphenidate and modafinil: comparison of product information for oral formulations in Australia, Denmark and the United States. Curr Drug Saf. 2013
Article last updated on: March 13th, 2018 by Nootriment
2 Comments
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