The use of natural Serotonin supplements like 5-HTP became popular after studies were done on their effects in the early 1990s and 2000s.
Supplementation of 5-HTP has been studied with positive results for mood regulation, sleep disorders, and obesity.
Increased amounts of the essential amino acid L-Tryptophan, a precursor for 5-HTP and Serotonin, also can lower the prevalence of these conditions.
While the building blocks for the neurotransmitter Serotonin can be derived from dietary foods, only a very small percentage of the Tryptophan in foods can be converted into Serotonin in the brain.
5-HTP pills are considered the most effective natural Serotonin booster supplements available without a prescription.



- Increases Serotonin levels in the brain
- Enhances mood and alleviates stress
- Improves sleep and regulates appetite
Do you Need Natural Serotonin Supplements?
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We need to consume Tryptophan in order for our bodies to make the neurotransmitter Serotonin.
As this is an essential amino acid, our bodies cannot produce it on their own. Foods that provide the amino acid Tryptophan include meat, dairy products and eggs, some grains and starches, certain vegetables and fruits, and some nuts and seeds.
Tryptophan contains one amino group that is present in all subsequent intermediates made in the biosynthesis of Serotonin. This amino group gives Serotonin monoamine neurotransmitters their distinctive binding properties.
If stress is high, moods are low, and sleep patterns are disrupted, it may be a sign that Serotonin levels are low. Some believe Serotonin deficiency is an epidemic around the world.
Declines in Serotonin levels may be linked to the steady rate of increasing proportions of depression, anxiety, restlessness, and even excessive weight gain.
In order to increase Serotonin levels, natural interventions may be recommended. In the past, it was believed that a deficiency could be alleviated by consuming higher quantities of Tryptophan-rich foods. However, recent pharmacokinetic studies show that less than 7% of all Tryptophan consumed can be made available for Serotonin synthesis.
A much smaller percentage of that amount is available to cross the blood-brain barrier so that Serotonin levels can be raised within our brain systems that regulate mood. For this reason, it is suggested that natural Serotonin supplements like 5-HTP may be a better alternative.
Benefits of Serotonin Boosting Supplements
In addition to increasing L-Tryptophan through dietary sources, supplementation of pure Tryptophan and 5-HTP can be used to increase levels of Serotonin in the body.
Serotonin and natural supplementation of 5-HTP are thought to provide a wide range of health benefits, including lowering the risk of mood disorders, improvement of sleep patterns, and regulation of appetite.
There have also been promising results from studies looking at 5-HTP in nutrient absorption and gut-brain reactions. Due to these potential health benefits, 5-HTP supplements, which are naturally converted to Serotonin, have become popular.
There is some clinical research evidence that the recommended amounts of 5-HTP may lower feelings of anxiety, and reduce the risk of depression, excess stress, insomnia, and obesity in people who are predisposed to Serotonin deficiencies. Natural supplements may also benefit people who may have less Tryptophan in their diet through a vegetarian or vegan lifestyle.
There are several brands of natural Serotonin boosting pills available including Absorb Health 5-HTP for cognitive support. Absorb Health 5-HTP is a mood regulating supplement that may be used to promote feelings of well-being and reduce food cravings.
Dosages of 5-HTP Supplements
The dose of natural Serotonin supplements depends on what you are using it for. Supplement providers recommend taking 50 or 100 mg up to three times a day.
While the maximum dosage is still debatable, the dosage for depression has been studied at a level of 200-300 mg taken in 100 mg increments up to three times per day.
The size of the individual taking the supplement should also be taken into consideration when setting dosage. Adults (18 years and older) should take no more than 8-15 mg/kg body weight per day and children (under 18 years) should take no more than 2-3 mg/kg body weight per day.
It is recommended to speak with your doctor before beginning any new supplements. Proper dosage is dependent on many factors including age, weight, physiology, personal sensitivities, and reasons for taking the supplement. Your doctor will be able to determine the best dosage for your needs and determine if there may be any negative interactions with any current medications.
Potential Serotonin Booster Side Effects
While generally safe, high doses of natural Serotonin supplements may have harmful effects, such as gastrointestinal (GI) issues including heartburn, abdominal pain, nausea, vomiting and diarrhea. Other possible side effects may include drowsiness and muscle problems.
Natural Serotonin supplements should only be used under medical care in people who have HIV, gastrointestinal disorders, schizophrenia, Down syndrome, seizure disorders, eosinophilia syndromes, slow heart rate (bradycardia), mitochondrial encephalomyopathy, suicidal thoughts, known allergy to products containing 5-HTP, and patients who are pregnant/nursing or going to be admitted for surgery within 2 weeks of supplementation.
Together with a healthy diet and lifestyle, natural serotonin supplements may increase overall quality of health and well being in some individuals when taken properly.
Herbs and supplements are not strictly regulated by the US Food and Drug Administration. Purity, safety and strength of products and effects may vary depending on manufacturer.
Always purchase your natural Serotonin boosting supplements from well-respected vendors that have a history of providing high quality products. Read user reviews and reports on side effects before ordering online. You should always read and follow instructions on product labels.
If you have a medical condition, or are using any other drugs, herbs, or supplements, speak with a qualified healthcare professional before use. Discontinue use of natural Serotonin supplements and consult a doctor if side effects occur.
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Article last updated on: May 4th, 2018 by Nootriment