Nature Made SAM-e Complete Supplement Review, Dosages & Safety

Nature Made SAM-e Complete is promoted as the best-selling brand of s-adenosylmethionine dietary supplements.

This product contains either 200 mg or 400 mg of SAM-e tosylate disulfate, a molecule that occurs naturally in the cells of the human body.

It is typically used to promote a positive mood and combat low feelings. According to the manufacturer, “Nature Made SAM-e Complete can help replenish your SAM-e level and restore your healthy mood naturally.”

Clinical research shows that taking this nutrient can restore a healthy mood in as little as 7 – 14 days. This supplement is also used to promote joint health, cartilage, liver health and to alleviate joint pain.

What makes Nature Made SAM-e Complete different from other nutritional supplements that contain this ingredient and should you buy it?

SAMe

Mood Supplement

Mood

Cognitive Health

Joint Function

How It Works:

• Enhances mood & promotes cognitive health
• Essentual for dopamine, serotonin & norepinephrine metabolism
• Promotes joint comfort & liver health

Dosage:

Between 400 - 1600 mg per day

Safety:

Rated Likely Safe

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View User Ratings* ❯

Nature Made SAM-e Review

According to Nature Made, SAM-e Complete helps support healthy moods and prevent joint pain.

The manufacturer states that, while SAM-e is produced naturally in the body, factors such as aging and diet may interfere with natural production.

Supplementing with SAM-e Complete can increase levels in the body. Additionally, this dietary supplement is a source of sulfur, which is a component of healthy joint tissue.

SAM-e was first isolated by Giulio Cantoni in 1952. In 1956, he reported that it is naturally produced in the human body. It is involved in several cell functions and maintains cell membranes.

This compound is produced from amino acids and helps the brain synthesize and process neurotransmitters that regulate mood such as dopamine, serotonin and melatonin. It is also shown to support immune health.

Supplement Uses

According to Nature Made, SAM-e Complete helps support joint comfort and a healthy mood. They say that the supplement supports detoxification and overall healthy liver function. It also reduces the frequency of anxiety, panic attacks and depression.

In studies, oral supplements containing this ingredient showed some benefit for the alleviation of depression symptoms. Studies indicate that SAM-e is more effective than a placebo and as effective as tricyclic antidepressant medications with a lower risk of side effects.

Clinical trials lasted up to 42 days. In some cases, people who did not respond to other therapies had success when taking SAM-e pills.

A number of clinical studies indicate that SAM-e is as effective as NSAIDs when taken for osteoathritis, including Celebrex. Participants experienced fewer symptoms and experienced fewer adverse side effects than those taking NSAIDs.

When taken for fibromyalgia, oral SAM-e improved symptoms significantly as compared to TENS unit therapy and a placebo.

How to Use

According to the manufacturer, SAM-e Complete 200 mg should be taken twice a day. SAM-e Complete 400 mg should be taken once a day.

Nature Made recommends taking this product first thing in the morning at least 30 minutes before consuming a meal. They state that if this causes side effects, you can split your dose in half and take 200 mg before breakfast and 200 mg before lunch.

It is recommended to take this supplement with water to make it easier to swallow. The manufacturer also recommends avoiding using it before bedtime as it could make it harder to fall asleep.

According to Nature Made, some users experience improvements in mood and emotional balance within one to two weeks of beginning to use this product. They say, “If after 2 weeks you are not experiencing desired benefits, you may want to try gradually increasing the dose after consulting with your doctor.”

Individuals taking this product for other reasons such as improving joint comfort may need to take it for a longer duration to see results. It can take up to one month to experience positive benefits on joint mobility and pain.

In research studies, other dosages used include the following:

For depression:

doses from 800 mg to 1600 mg SAM-e. Doses should be divided and taken in the morning and afternoon. It may be beneficial to start with smaller dose and gradually increase it.
• For fibromyalgia pain: 400 mg SAM-e was taken twice per day.
• For osteoarthritis: 600 to 1200 mg per day. This is typically divided into two to three doses.

Many people recommend combining SAM-e with a B-vitamin supplement.

Side Effects

SAM-e is a naturally-produced compound that the human body makes on its own. As a dietary supplement, it is generally well tolerated with a low risk of negative effects.

The most common side effects of supplements like SAM-e Complete are nausea and upset stomach. Some people also experience headache, insomnia and restlessness, especially when taking large doses of SAM-e.

According to Nature Made, “You can continue taking SAM-e as long as you are not experiencing any adverse effects and experience results.”

Women who are pregnant or breastfeeding should not take this supplement due to a lack of research available to assess safety in these groups. It is not known whether SAM-e is safe for children to take.

This product may increase mania symptoms in people who have bipolar disorder. It may interact with the cough medicine dextromethophan.

It could may cause serotonergic effects and raise an individual’s risk for serotonin syndrome. There is also a possibility that it could cause Call-Fleming syndrome.

SAM-e may interfere with the effectiveness of the Parkinson’s drug levodopa. It may cause negative effects when combined with Demerol, tramadol and other opiate medications.

This supplement should be discontinued for two weeks prior to surgery because of possible effects on the vascular system.

Customer Reviews

Nature Made SAM-e Complete is one of the best-selling s-adenyl methionine supplements on Amazon with a rating of 4.3 stars at present. Sixty-seven percent of the supplement’s 432 reviews are five-star reviews.

A number of five-star reviewers state that SAM-e is highly effective for managing their moods, including managing major depression.

Some reviewers complain of stomach upset when taking Nature Made SAM-e. However, one reviewer says that stomach symptoms were avoided by taking the supplement on an empty stomach with eight ounces of water and avoiding eating for at least one hour after administering it.

Some reviewers report having to take SAM-e for at least two weeks before seeing results. Others say that they felt an improvement in depression symptoms within a few days of beginning to take the product.

Among one-star reviewers, the most common complaint was gastrointestinal distress. A handful of reviewers also report that SAM-e Complete made them feel irritable or nervous. Some reviewers expressed concern that talc, one of the inactive ingredients, cannot be digested.

Where to Buy

Based on point of sale data in retail establishments, Nature Made is the top-selling brand of SAM-e supplement in the United States.

This supplement is available in 200 mg and 400 mg capsules. It can be purchased at a number of brick and mortar retailers, such as local pharmacies and grocery stores.

It can also be found online at sources that include Amazon.com, Jet.com and Costco.com. Bottle sizes range from 24-count to 120-count bottles.

You do not need a prescription to buy SAM-e Complete by Nature Made. However, it is recommended to consult with a doctor before taking this supplement to determine whether it is appropriate for you.

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