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Nefiracetam is one of several more powerful members of the Racetam class of Nootropics to hit the market recently.
If you have seen positive results with compounds such as Piracetam or Aniracetam, you may be interested in experimenting with this cognitive enhancer to see how its effects compare.
Nefiracetam is particularly similar to Aniracetam in terms of chemical structure, though its mechanism of action is slightly different.
It seems to enhance both the GABA and Acetylcholine neurotransmitter signaling systems within the brain, resulting in a positive impact on learning, focus and memory.
Long-term use of a Nefiracetam dosage offers Nootropic as well as neuroprotective benefits.
This supplement is fat soluble like Aniracetam, which enables it to more easily cross over the blood-brain barrier and enter into the central nervous system.
This is at least partially responsible for Nefiracetam having better penetration into the brain and for being longer lasting than many other Nootropics.
Nefiracetam reviews also say that it has a wider reaching range of effects than its closest relatives Aniracetam and Piracetam.
What is the right way to use this nootropic and what would a safe Nefiracetam dosage be considered?
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Brain Health- Promotes brain health & communication
- Supports memory, reasoning & cognition
- Boosts focus, mental clarity & attention
Reasons to Use Nefiracetam
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This supplement has shown strong potential in the treatment of seizures, both convulsive and non-convulsive.
While studies have shown that it does not have much of an effect upon stopping seizures from occurring, when taken immediately prior to, or during, a stroke it can greatly reduce the number and duration of seizures that may occur after the event.
Nefiracetam is also capable of inducing a number of the typical Nootropic benefits that would be expected from such a supplement.
These include improving memory and learning capacity, especially related to long-term memory and learning (most Nootropics are much more effective at short-term improvements).
Spatial learning is also particularly enhanced. This supplement is one of the best Nootropics in terms of increasing attention spans, concentration, and focus.
There is also evidence suggesting that it offers benefits for patients and depression.
Another feature of this supplement is its ability to protect the neurons within the brain. This seems to be particularly helpful at protecting and possibly even reversing damage done to the hippocampus section of the brain.
It may even aid in protecting neurons from undergoing cell death in the presence of certain types of neurotoxins by improving oxygen supply to brain cells. While there are medical implications for this mechanism of action, it could also offer anti-aging benefits as well as help individuals who use certain drugs.
Nefiracetam Dosage:
How much Nefiracetam should you be using and what is the right way to administer your dosage? There have been a number of studies which indicate different methods for determining the proper dosage of Nefiracetam.
One study indicates the recommended dosage should be between 8.72 mg per kg of body weight and 29.07 mg/kg. Of course, this dosage is intended for treating the negative cognitive effects of seizures and severely depressed individuals.
A more general accepted dosing guideline for cognitive enhancement purposes falls between the range of 5 to 16 mg/kg. This works out to be between 330 and 1100 mg for a 150 pound person.
You can achieve precise dosage control by purchasing a supply of bulk Nefiracetam powder and measuring out your dosage daily with an electric scale. However, it is also possible to buy Nefiracetam tablets in 500 mg doses and then split these tablets in half if needed.
It is also noted that this dose should be divided into two or three equal administrations, taken throughout the day. This supplement is very fast acting, reaching and affecting the brain within 30 to 60 minutes following oral administration.
That being said, it may require several days or weeks of dosing before the full effects of this supplement are felt in most people. This is fairly common across the board with Racetam nootropics, though most user reviews say that the effects of Nefiracetam are observable in a shorter duration of time than with Piracetam.
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Nefiracetam Side Effects:
Most of the side effects currently associated with Nefiracetam are similar to those associated with other Racetams.
They include headaches, nausea, irritability, fatigue, dizziness, and stomach issues. In the majority of cases, these effects are mild and will pass quickly.
As for Racetam headaches, they can usually be overcome by adding a high quality Choline supplement (Alpha GPC, CDP Choline). Most of the other issues do not show up unless the supplement is being used in excessively high doses.
Almost all current studies used to measure the effectiveness of Nefiracetam have been conducted on animals. However, there does not seem to be any toxicity risk for human consumption. Although no upper limit for consumption has been established at this point, 900 mg per day has been determined to be non-toxic.
Higher doses are also seen as likely to be safe, but are untested at this point. Larger Nefiracetam dosages may have marginal benefits, but due to a U-shaped dosage curve most people avoid taking more for the sake of cost effectiveness.
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- Omotuyi OI, Ueda H. Molecular dynamics study-based mechanism of nefiracetam-induced NMDA receptor potentiation. Comput Biol Chem. 2015
- Lu XC, Dave JR, Chen Z, Cao Y, Liao Z, Tortella FC. Nefiracetam attenuates post-ischemic nonconvulsive seizures in rats and protects neuronal cell death induced by veratridine and glutamate. Life Sci. 2013
- Moriguchi S. Pharmacological study on Alzheimer's drugs targeting calcium/calmodulin-dependent protein kinase II. J Pharmacol Sci. 2011
- Moriguchi S, Shioda N, Maejima H, Zhao X, Marszalec W, Yeh JZ, Fukunaga K, Narahashi T. Nefiracetam potentiates N-methyl-D-aspartate (NMDA) receptor function via protein kinase C activation and reduces magnesium block of NMDA receptor. Mol Pharmacol. 2007
- Kitano Y, Komiyama C, Makino M, Takasuna K, Satoh H, Aoki T, Kinoshita M, Takazawa A, Yamauchi T, Sakurada S. Anticonvulsant and neuroprotective effects of the novel nootropic agent nefiracetam on kainic acid-induced seizures in rats. Brain Res. 2005
- Pak J, Green J, Heifets B, Pak M, Woodruff-Pak D. Nefiracetam ameliorates associative learning impairment in the scopolamine-injected older rabbit. Med Sci Monit. 2002
- Yoshii M, Watabe S, Murashima YL, Nukada T, Shiotani T. Cellular mechanism of action of cognitive enhancers: effects of nefiracetam on neuronal Ca2+ channels. Alzheimer Dis Assoc Disord. 2000
- Oyaizu M, Narahashi T. Modulation of the neuronal nicotinic acetylcholine receptor-channel by the nootropic drug nefiracetam. Brain Res. 1999
- Woodruff-Pak DS, Hinchliffe RM. Mecamylamine- or scopolamine-induced learning impairment: ameliorated by nefiracetam. Psychopharmacology (Berl). 1997
- Woodruff-Pak DS, Li YT, Hinchliffe RM, Port RL. Hippocampus in delay eyeblink classical conditioning: essential for nefiracetam amelioration of learning in older rabbits. Brain Res. 1997
- Woodruff-Pak DS. Nefiracetam ameliorates learning deficits in older rabbits and may act via the hippocampus. Behav Brain Res. 1997
- Hiramatsu M, Shiotani T, Kameyama T, Nabeshima T. Effects of nefiracetam on amnesia animal models with neuronal dysfunctions. Behav Brain Res. 1997
- Huang CS, Ma JY, Marszalec W, Narahashi T. Effects of the nootropic drug nefiracetam on the GABAA receptor-channel complex in dorsal root ganglion neurons. Neuropharmacology. 1996
- Takeo S, Fukatsu T, Miyake-Takagi K, Takagi N, Niimura M, Nagakura A, Ando T, Tanonaka K. Persistent effects of delayed treatment with nefiracetam on the water maze task in rats with sustained cerebral ischemia. J Pharmacol Exp Ther. 2003
- Rashid MH, Ueda H. Nonopioid and neuropathy-specific analgesic action of the nootropic drug nefiracetam in mice. J Pharmacol Exp Ther. 2002
- Yoshii M, Watabe S, Sakurai T, Shiotani T. Cellular mechanisms underlying cognition-enhancing actions of nefiracetam (DM-9384). Behav Brain Res. 1997
- Doyle E, O'Boyle KM, Shiotani T, Regan CM. Nefiracetam (DM-9384) reverses apomorphine-induced amnesia of a passive avoidance response: delayed emergence of the memory retention effects. Neurochem Res. 1996
- Woodruff-Pak DS, Li YT. Nefiracetam (DM-9384): effect on eyeblink classical conditioning in older rabbits. Psychopharmacology (Berl). 1994
- Fujikawa K, Akiyama Y, Takayama S. Drug dependence study of the new cognition-enhancing agent nefiracetam in rats. Arzneimittelforschung. 1994
- Watabe S, Taniguchi K, Kojima H. Improvement of impaired brain monoamine metabolism by the cognition-enhancing agent nefiracetam after microsphere-induced cerebral embolism in rats. Arzneimittelforschung. 1994
- Woodruff-Pak DS, Green JT, Pak JT, Shiotani T, Watabe S, Tanaka M. The long-term effects of nefiracetam on learning in older rabbits. Behav Brain Res. 2002
- Aihara H, Li X, Fujiwara S, Matsumura T, Okumura S, Tozaki H, Kanno T, Ohta K, Nagai K, Nishizaki T. The protective action of nefiracetam against electrophysiological and metabolic damage in the hippocampus after deprivation of glucose and oxygen. Brain Res. 2001
- Nishizaki T, Nomura T, Matuoka T, Kondoh T, Enikolopov G, Sumikawa K, Watabe S, Shiotani T, Yoshii M. The anti-dementia drug nefiracetam facilitates hippocampal synaptic transmission by functionally targeting presynaptic nicotinic ACh receptors. Brain Res Mol Brain Res. 2000
- Abe E, Murai S, Saito H, Masuda Y, Itoh T. Effects of nefiracetam, a novel pyrrolidone derivative, on brain monoamine metabolisms in mice. J Neural Transm Gen Sect. 1992
Article last updated on: March 13th, 2018 by Nootriment
1 Comment
Looks like your dosing info is x10 too high:
source: examine.com/supplements/Nefiracetam/
“Animal studies using acute doses tend to note most benefits in the 3-10mg/kg range, and this correlates to a human dose of 0.48-1.6mg/kg (for a 150lb person, 33-110mg) which is similar to the aforementioned human doses.”
…you wrote 5 – 16 mg/kg, so you forgot to add a decimal.