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NeuroPEPT is one of the brand names for the nootropic compound N-phenylacetyl-L-prolylglycine ethyl ester, better known as Noopept.
NeuroPEPT 20mg is sold by Cognitive Nutrition and is used as a “smart pill” to promote memory, learning, reasoning and communication skills.
The active ingredient Noopept is described by users as enhancing focus, mental energy, alertness, awareness, verbal fluency, motivation as well as exhibiting an anxiolytic effect.
This nootropic agent was developed in Russia as was originally researched for its ability to protect the brain from oxidative damage.
It is a more potent derivative of Piracetam – the most popular nootropic used today – and has been found to be better tolerated in research studies.
Neuropept is believed to enhance communication between neurons in the brain and promote neuroplasticity. It has been shown to increase expression of the neurotrophins NGF and BDNF.
Neuropept is reported to be safe in research studies conducted so far, but there have not been any human studies examining the effects of long-term use or taking it at high dosages.
This nootropic supplement is not associated with serious side effects when used appropriately, but not everyone experiences benefits from taking it.
Mental Energy
Memory
Brain Health- Supports memory, focus & mood
- Boosts mental alertness & energy
- Increases BDNF & promotes brain health
Why Use Neuropept?
Related Topics
- What is Noopept?
- User Reviews
- Reported Benefits
- How it Works
- Negative Side Effects
- Typical Experiences
- Recommended Dosage
- Best Way to Take
- Stacking with Choline
- Recommended Nootropic Stacks
- Purchasing Guide
- Bulk Noopept Powder
- Buy Noopept Capsules
- Is Noopept Legal?
- Comparison to Piracetam
- Comparison to Aniracetam
- Comparison to Oxiracetam
- Comparison to Pramiracetam
According to Cognitive Nutrition, Neuropept “was created in Russia in the 1990’s as a superior precursor to your own endogenous brain peptide (combination of natural amino acids) Cyclo-L-prolylglycine that has a wide range of cognitive protective and enhancement affects.”
Neuropept is marketed as the 3rd generation of the original nootropic Piracetam. (The 2nd generation would be Aniracetam which was developed shortly after this first Racetam was synthesized.)
Neuropept gets its name from the fact that it is a peptide nootropic. Peptides are short chains of protein-like molecules that are held together by peptide bonds.
Neuropeptides are important signalling molecules in the brain made up of a combination of natural amino acids.
The active ingredient in Neuropept is a precursor to the neuropeptide cycloprolylglycine, which has a number of different effects on cognitive function.
Noopept crosses the blood-brain barrier and gets converted into cycloprolylglycine following administration. It is through this metabolite that it exhibits most of its effects on cognition.
Noopept appears to increase activation of acetylcholine receptors, which are linked to memory, attention and sensory perception. This nootropic also has a mild stimulant effect as well as a mood boosting and anti-anxiety effect.
Some of the benefits from using Noopept as observed in user reviews are listed below:
- Heightened ability to learn and retain information
- Improves encoding and consolidation of long-term memory
- Promotes greater synaptic plasticity and increases neuron receptor density in the Hippocampus
- Boosts concentration, alertness and attentiveness
- Better working memory and logical reasoning skills – particularly in performing calculations and processing information
- Advanced verbal communication skills
- May boost mood, reducing signs of anxiety and
- Enhanced reflexes and perceptual awareness
- Increases interhemispheric communication in the brain leading to better problem solving and creativity
- Increases Nerve Growth Factor and Brain-Derived Neurotrophic Factor expression, leading to improved neuron development, growth and repair
- Protects against damage to brain cells from oxidative stress and (i.e. drinking alcohol)
Note that not everyone responds in the same way to Noopept or NeuroPEPT. User reports show a wide range of experiences.
Some people feel little to no effects when taking this nootropic supplement while others say that it is the strongest cognitive enhancer they have used.
Others have negative experiences and say that it causes them to feel overly anxious or results in worsening of focus and short-term memory.
You can read 95 user reviews on the positive and negative effects of Noopept here.
- 1000x more potent than Piracetam
- Supports memory, focus and mood
- Boosts mental alertness and energy
How Does Neuropept Work?
Neuropept exhibits a number of different mechanisms of action which may contribute to enhanced mental performance, brain health and memory.
Research shows that it can have a positive effect on cognitive ability in subjects that have Alzheimer’s Disease, Senile Dementia, Cerebrovascular Disorder and other conditions that impair long-term memory function.
One of the observed effects of this nootropic agent is to increase alpha and beta brain wave activity in different parts of the brain. It has been shown to increase activity in more parts of the brain than Piracetam based on EEG data.
This is linked to increased overall cognitive ability, alertness, wakefulness and focus.
Noopept has been described as an Ampakine because it increases activation of brain receptors for the neurotransmitter glutamate known as AMPA receptors.
These receptors are found on neurons that are involved in controlling how memories are encoded for long-term storage. This process is called Long-Term Potentiation.
AMPA receptors respond to the neurotransmitter Glutamate when it is released from neighboring neurons. Neuropept has the effect of adjusting or modulating these synaptic receptors so that they are even more sensitive to Glutamate when it is released.
The result is a greater level of brain activity, and is theorized to promote enhanced memory formation and recall.
The active compound Noopept has also been shown to inhibit the breakdown of glutmate following its release from the pre-synaptic neuron terminal. This allows the neurochemical to be active in the synaptic cleft for a longer duration and increases stimulating of glutamatergic receptors.
Noopept is sometimes described as a Racetam nootropic and may be referred to as “omberacetam”. Compared to the racetam nootropic Piracetam, it is cited as being over 1,000 times stronger.
While it shares similar effects with other racetam drugs, it does not technically have the same chemical structure as racetams.
Racetams are known for influencing acetylcholine pathways in the brain. They are observed to increase acetylcholine synthesis and to increase the sensitivity of cholinergic receptors in areas of the brain linked to working memory and sensory perceptions.
This neurotransmitter is also involved in processes related to verbal reasoning, concentration, arousal, behavior regulation and attention.
By stimulating greater acetylcholine activity, Neuropept is purported to boost short-term (working) memory capacity and may improve your ability to concentrate.
Neuropept also interacts with Dopamine receptors in the brain and has a positive effect on Serotonin receptors. These two neurotransmitters play an important part in regulating your mood and emotional responses to different stimuli.
By stimulating receptors for these brain chemicals, Neuropept may have a mood-lifting effect while also curbing anxious or stressful thoughts. Some users say this supplement causes them to experience greater mood stabilization and can result in higher levels of motivation and productivity.
Finally, Neuropept is considered to be neuroprotective which means it contributes to healthy cellular function in your brain and may be able to reverse or protect against damage.
While there have been promising initial results in studies on Noopept, more research is needed to evaluate the effects of Noopept on cognitive function in healthy adults. Most of the studies conducted so far have involved patients diagnosed with some form of traumatic brain injury or age-related brain degeneration.
How to Take NeuroPEPT
Each capsule of NeuroPEPT contains 20 mg of the active ingredient Noopept. Typically, this nootropic is taken in dosages of between 5 – 30 mg per day.
Cognitive Nutrition recommends a higher dosage range of 20 mg – 60 mg per day. According to the manufacturers, it is suggested to “Take 1-3 capsules as needed or on weekdays in the morning and/or afternoon. We recommend starting with one capsule in the morning and increasing as needed.”
It is important to start with the lowest effective dosage and only increase after you have had the opportunity to gauge how this compound affects you.
Cognitive Nutrition recommends using this nootropic drug as a core element in a stack. For the best results, it is advised to stack it with Alpha GPC or CDP Choline to enhance acetylcholine synthesis.
Alpha GPC and CDP Choline (Citicoline) are two types of choline supplements. This is a dietary nutrient found in egg yolks, beef liver, chicken and other protein sources that is the precursor to the neurotransmitter acetylcholine.
Using NeuroPEPT without a choline source can sometimes lead to headaches, brain fog, lack of mental clarity or irritable mood. If you experience these symptoms, try adding or adjusting the dosage of choline you are taking in your nootropic stack.
While many users do experience benefits from taking Noopept orally, a number of users say that it is more effective if consumed sublingually. Some have also seen better results with use of nasal sprays containing this ingredient.
If you are non-responder to oral use of Neuropept, you may find that sublingual use of Noopept powder is more effective.
- Focus longer, clear brain fog & feel more motivated
- Boost energy, alertnes & memory
- Contains 12 safe and natural nootropic ingredients
Buy Neuropept
There are many advertised benefits to using the Neuropept brain supplement product from Cognitive Nutrition.
While Neuropept is considered to be a good source of the Noopept supplement, it is significantly more expensive than generic formulations.
You are paying a major premium for the Cognitive Nutrition brand name without any difference in the effectiveness of this compound.
To illustrate this point, you can purchase Neuropept in 30 capsule bottles for $19.99. Each capsule contains 20 mg of active Noopept, amounting to a price of $0.67 per 20 mg dosage.
Comparatively, you can buy 10 grams of Noopept powder in bulk for $29.99. This means that a 20 mg dose would cost you $0.06 which is roughly a discount of 90% compared to Neuropept.
There are also a number of other forms of this smart drug available, including oral capsules, liquid solutions, pre-formulated nootropic stack supplements and drink mixes like the TruBrain Think Drinks.
If you do decide to purchase generic Noopept powder, it is a good idea to buy an accurate digital scale that can measure in amounts as small as 1 milligram.
Since Noopept powder is active at very low doses, it requires precision in terms of measuring your doses. It can be very easy to take too much if measuring a dosage of bulk powder.
These scales can be purchased online for less than $20 and are small enough to stick in a laptop bag or purse. You can then mix your Noopept powder into milk or some other liquid to drink.
Another popular option is to use this nootropic sublingually which means that you place it under your tongue and allow it to quickly absorb directly into your bloodstream.
Many users find this to be a more effective way of administering this supplement.
If you decide to use the Neuropept branded supplement in this way, you could in theory open the pill capsule and place the contents under your tongue, however this is likely to be both expensive and inconvenient.
Before taking Neuropept or Noopept, we recommend that you read our article on the potential side effects of this cognitive enhancer and ways to reduce their risk.
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- Bukanova JV, Solntseva EI, Skrebitsky VG. Selective suppression of the slow-inactivating potassium currents by nootropics in molluscan neurons. Int J Neuropsychopharmacol. 2002
- Ostrovskaya RU, Gudasheva TA, Zaplina AP, Vahitova JV, Salimgareeva MH, Jamidanov RS, Seredenin SB. Noopept stimulates the expression of NGF and BDNF in rat hippocampus. Bull Exp Biol Med. 2008
Article last updated on: March 13th, 2018 by Nootriment