Nicergoline is an ergot derivative used primarily to treat senile dementia and other disorders which are known to have a vascular origin. It is known to decrease vascular resistance and increase arterial blood flow within the brain, thus improving the utilization of oxygen and glucose uptake by brain cells.
These protective effects also extend to a number of other organs including the lungs. Nicergoline is also used for other vascular disorder which include cerebral thrombosis, atherosclerosis, arterial blockages in the limbs, Raynaud’s disease, vascular migraines, and retinopathy.
In addition to the above, Nicergoline is also used as a Nootropic, or smart drug. These so-called cognitive enhancers are often used to help improve brain function, whether it has been impaired or not. Some of the known Nootropic benefits associated with this supplement include enhanced mental clarity, overall improved perception, focus, and concentration.
Over the past 30 years or so, this has become one of the most highly regarded brain concentration supplements on the market (especially in regards to improving mental agility). This drug is also currently being used in the treatment of many different forms of dementia, including Alzheimer’s disease.



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Nicergoline Effects:
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There are several mechanisms of action for Nicergoline. It appears to work by stimulating alpha-adrenolytic action. This essentially activates the brain’s metabolism.
When this occurs, a number of other processes and activities begin to flow as well. These all lead to an increase in arterial blood flow (to the brain as well as other organs like the lungs).
This helps to reduce any vascular resistance and also improves the uptake and use of both oxygen and glucose within the brain.
Another interesting, if not unique, mechanism of action for this supplement is by acting upon the blood itself.
Nicergoline has been shown to inhibit platelet aggregation (the process of blood particles basically clumping together) and blood clots. This action by itself is incredibly beneficial in terms of reducing the risk for strokes and also in maintaining overall brain health and function.
Research also indicates that the supplement does not affect arterial tension, and that it may actually lead to a gradual reduction in this tension for patients who have high blood pressure currently.

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Nicergoline Benefits:
As a Nootropic supplement, Nicergoline is useful in improving a number of cognitive functions. Many users report seeing enhanced mental clarity, perception, and even improved concentration, focus, and attention spans.
These benefits can be seen in people of all ages, but are appear to be more effective in older people. This is also possibly why the supplement has been very helpful in treating those with senile dementia and Alzheimer’s disease. It may even increase nerve growth in an older brain.
Another benefit of this supplement is in the treatment of blood related issues. This includes transient ischemia, which is a situation characterized by occasional blood supply difficulties.
It is also helpful with the treatment of sticky blood platelets, improving blood flow and circulation in the limbs, lungs, and even within the brain itself. This also serves to increase both oxygen and glucose uptake, providing the brain with more working fuel and energy to conduct more efficient operations.
Nicergoline has also been found effective at treating a neurological condition in which the walls of blood vessels in the brain begin to harden. Migraines which stem from vascular problems are also treatable with this supplement. So is macular degeneration, which is a fairly common age-related eye problem that can lead to blindness.
Other vascular problems may be successfully treated with Nicergoline administeration. Even dizziness can sometimes be helped when it is related to deficiencies in the conductive hearing organs. This can also include auditory hallucinations and other hearing impairments.
Nicergoline Dosage:
The recommended dose of Nicergoline will depend upon the desired type of treatment.
For example, using this for help with age-related macular degeneration and blood disorders would probably lead to a doctor recommended dose of 5 mg one to three times per day. On the other hand, someone suffering from senile dementia might be required to take 30 to 60 mg per day.
When taking larger doses, it should be split into divided administrations throughout the day. This is useful in keeping a constant supply of the supplement within your system. As with any other Nootropic, you should cycle this, taking occasional breaks in order to avoid developing tolerance.
Nicergoline Side Effects:
This supplement is considered to be very safe and well-tolerated. Of course, there have been some side effects associated with Nicergoline. For the most part, these are very mild and may include nausea, hot flashes, mild gastric upset, hypotension, and dizziness.
At high doses, bradycardia, increased appetite, agitation, diarrhea, and perspiration have been seen. You should avoid taking this supplement in combination with other ergots (Hydergine), especially in high doses. Please be sure to read the label and follow all manufacturers’ guidelines.
Nicergoline Review:
This is one of the more interesting Nootropics on the market today with positive effects both from a standpoint of neurological health and for mental performance. It is known to treat several different vascular conditions which can impair brain function as well as lead to other difficulties throughout the body.
From a cognition enhancement perspective, it is not as effective as a number of other Nootropics but it does offer moderate benefits. These benefits primarily relate to the blood flow and energy supply provided to the brain as opposed to some of the neuron-specific effects of nootropics like Piracetam, Aniracetam or Noopept.
You should remember that there are always inherent risks when taking a drug like Nicergoline for so-called “off-label” purposes.
Article last updated on: March 3rd, 2018 by Nootriment
1 Comment
Why this medicine has been banned in France and withdrawn from the market ?