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Some people prefer using Noopept Nasal Spray over more common orally-administered forms – like powder and capsules.
Using Noopept in the form of a nasal spray has not been well-researched. Information available at present is largely based on anecdotal evidence posted in user reviews online.
Some people find that taking this nootropic via insufflation (intranasal administration) makes it more effective and produces faster results. This method of administration is also purported to require a lower dosage as more of the active ingredient crosses the blood-brain barrier.
Noopept is a nootropic and neuroprotective agent that is often grouped with the racetam drugs. It is sometimes referred to as Omberacetam but does not qualify as a racetam because it has a different chemical structure.
It was developed in Russia in the 1990s and is commonly used as a smart drug to improve memory, maintain neuroplasticity, support mood, increase energy, and enhance overall cognitive function. [1]
This article reviews the use of Noopept nasal spray, the effects of taking this nootropic via insufflation, potential dangers and the overall safety profile of this popular brain-boosting compound.
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Noopept Nasal Spray
Related Topics
- What is Noopept?
- User Reviews
- Reported Benefits
- How it Works
- Negative Side Effects
- Typical Experiences
- Recommended Dosage
- Best Way to Take
- Stacking with Choline
- Recommended Nootropic Stacks
- Purchasing Guide
- Bulk Noopept Powder
- Buy Noopept Capsules
- Is Noopept Legal?
- Comparison to Piracetam
- Comparison to Aniracetam
- Comparison to Oxiracetam
- Comparison to Pramiracetam
In Russia and some surrounding countries, Noopept (n-phenylacetyl-l-prolylglycine ethyl ester) is prescribed by doctors as a cognitive enhancer and brain protector.
It is used clinically to help prevent or manage symptoms of: [2]
- Alzheimer’s disease, Parkinson’s disease and other neurodegenerative conditions;
- Cognitive decline associated with aging;
- CFS (chronic fatigue syndrome);
- Traumatic brain injury;
- Depression;
- Poor mood;
There are other medical uses for Noopept not listed above and it has been studied in a number of models of brain disorders. However, it has not been approved by the FDA as a drug for the treatment of any medical conditions.
In most countries, Noopept is not regulated and is a legal over-the-counter product that can be purchased without a doctor’s prescription. It is legal to buy Noopept and use it as a nootropic in the United States, Canada, and most of Europe.
This product is typically sold in the form of an oral capsule or bulk powder. Some supplement manufacturers include it as an ingredient in nootropic stacks with other compounds designed to support memory and focus.
There are also a small number of retailers who now sell intranasal Noopept products over the internet. Ceretropic, LiveCortex, LimitlessLife and NootropicSource are some of the best-known retailers who sell nasal sprays.
Note that the online vendors who carry this product state that it is not intended for human consumption. This product is sold for “Laboratory Research Use Only”. [3]
Some users also report combining small doses of Noopept powder with bacteriostatic water (a sterile preparation of water typically used in injections) to make their own liquid solutions for use as a nasal spray. This may increase the risk of adverse reactions if the solution is not prepared properly.
Common dosage recommendations range between 10-30 milligrams (mg) daily for powders and oral tablets. When used in the form of a nasal spray, smaller dosages are typically used.
Some people that have insufflated this nootropic nasally report that is quite a lot stronger. On While there is no standardized dosage available, the typical dose for administering Noopept intranasally is 1.5 mg.
Dosages can vary depending on the concentration of the ingredient provided by the spray and the type of bottle it is sold in. Always start with a low dose before increasing to minimize the risk of negative effects.
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Noopept Insufflation
Noopept is said to be roughly one-thousand times more potent than Piracetam – the prototype of all racetam nootropics. Even though this nootropic is significantly more potent than the racetams, it demonstrates low oral bioavailability.
Only a small amount of the dosage consumed in oral form crosses the blood-brain barrier. When you ingest this nootropic, it gets significantly degraded within the gastrointestinal tract.
As a result, many users experiment with different ways to administer it that allow it to cross the blood-brain barrier more effectively and increase its effects.
Examine.com states that, “A true bioavailability study has not been conducted, although it appears that an oral dose is about the equivalent of one-tenth an injected dose (10% bioavailability).” [4]
Most people do not have access or proper knowledge to administer Noopept intravenously. However, sublingual (under the tongue) dosing and insufflation are both becoming more popular in the nootropic realm.
According to Psychonautwiki, “As a peptide, the oral bioavailability is very low. Insufflation and sublingual administration are sometimes preferred because its absolute bioaccessibility is on average 10%.” [5]
One popular strategy is to take this nootropic powder sublingually, which means placing it under the tongue. From here, it gets absorbed directly into the bloodstream through the mucosal membrane.
Taking noopept intranasally is said to produce even stronger results than using it sublingually. While there are no human research studies available to compare the effects, there are numerous user reviews with individuals reporting positive effects.
What Is Insufflation?
Insufflation is defined as the act of blowing something into a body cavity. It could be a powder, liquid, vapor, or a gas and it is commonly used as a method of administration for drugs.
“Snorting” is technically distinct from the act of sufflation (being “blown” in), but the two terms are often used interchangeably.
Many drugs and other substances are administered via insufflation by doctors. Some of these include:
- ADHD (attention deficit hyperactivity disorder) medications;
- Hormone and nicotine replacement therapies;
- Antiasthma and decongestant medications;
- Migraine headache medications;
- Vaccines;
- Steroids;
According to Wikipedia, drugs that are administered intranasally tend to have higher bioavailability compared to orally administered drugs with an onset of effects only “marginally slower than if given intravenously.” [2]
Intranasal administration of Noopept nasal spray may also be a good choice for people who are resistant to swallowing capsules, or who cannot tolerate the bitter taste of the powder in their mouths for sublingual dosing.
One nootropic review site states, “The nose enables certain drugs and other molecules to bypass the blood-brain barrier via diffusion through the olfactory epithelium and the perineural sheath or via retrograde axonal transport along olfactory and trigeminal nerves.”
This source states that the inside of the nostrils is very well-vascularized; meaning they contain numerous capillaries that make it easy for a substance to transfer into them subdermally when applied topically.
Snorting or insufflating Noopept is also said to increase its bioavailability because it bypasses the gastrointestinal tract. As a neuropeptide, this compound gets degraded when it passes through the gut meaning that only a small amount survives in tact and gets absorbed into the body.
Some nootropics are not suitable for snorting because they need to be broken down by the liver to get converted into their bioactive metabolites.
For instance, the popular stimulant Adrafinil must be metabolized hepatically to get converted into its more-potent metabolite, Modafinil.
Noopept does not need to undergo hepatic metabolism to become active in the body which is why taking it intranasally could be effective.
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Is Snorting Noopept Dangerous?
Is snorting Noopept dangerous and can it cause a higher risk of side effects compared to oral administration. While the act of snorting itself is not dangerous, there is insufficient research available to evaluate the safety of noopept insufflation.
The only evidence available at this time comes from user reviews. There have been no double-blind placebo-controlled studies examining the safety profile of taking this nootropic in the form of a nasal spray.
There are some mentions of people developing inflamed nostrils after snorting Noopept powder. However, they are rare.
Insufflating this drug is not said to cause a strong “burn” like some illicit drugs including methamphetamine.
Many users state that they have significantly more-noticeable Noopept effects after nasal or sublingual administration relative to oral administration.
General Safety Review
Noopept is not technically a racetam because it lacks a 2-pyrrolidone nucleus in its molecular structure. However, like the racetam nootropics, it is considered safe and is well-tolerated in most users.
This nootropic drug is said to be non-toxic, non-addictive and unlikely to cause serious adverse reactions in most people.
However, some users do experience mild adverse effects that necessitate discontinuation of the drug. The most common reported side effects are an acetylcholine headache, irritability, and mild sedation.
The acetylcholine headaches that some nootropic users experience can normally be remedied by taking a quality choline supplement, like Alpha GPC or Choline Bitartrate, for example.
You can also improve your choline status by increasing your consumption of dark-green leafy plants like spinach, collard greens, kale, dandelion greens, and various other foods like eggs and poultry.
You should not snort, insufflate or otherwise take Noopept for more than 56 days consecutively. After 8 weeks, take a few weeks off so that you do not build a tolerance to this nootropic agent.
Noopept may increase cross-tolerance with racetams like Piracetam, Aniracetam, Oxiracetam, Pramiracetam, and Phenylpiracetam.
Use this compound in nootropic stacks with caution, and only after you understand how it affects you when you use it by itself.
Noopept dosages over 20 mg/day can cause brain fog, memory loss, headache, and other adverse effects. Not everyone responds positively to effects of this smart drug and you should only take this compound under the guidance of a qualified physician.
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- Ballow, R. NOOPEPT NASAL SPRAY – EFFECTS, EXPERIENCES, & DOSAGES. May 11, 2016. Accessed March 23, 2018
- Nootropix Staff. Nasal Administration of Noopept: Safety and Efficacy. Accessed March 23, 2018
- Wikipedia contributors. "Insufflation (medicine)." Wikipedia, The Free Encyclopedia. Wikipedia, The Free Encyclopedia, 5 Mar. 2018. Web. 23 Mar. 2018.
- Examine Staff. Noopept. Accessed March 23, 2018
- "Noopept." PsychonautWiki, . 14 Jan 2018, 05:18 UTC. 23 Mar 2018, 18:26
Article last updated on: July 9th, 2018 by Nootriment