Nootropics are supplements which have significant impact upon a number of different cognitive processes.
This includes increasing memory, improving learning capacity, expanding attention spans, and even increasing overall focus and concentration.
These supplements work in a variety of way, but mainly by modulating or influencing a number of different neurotransmitters within the brain.
Anyone who is interested in improving their overall cognitive functions or expanding their brain power should seriously consider the Nootropics as a viable option.
Typical questions from first-time nootropic users include which formulations are the best to use, how to actually take Nootropics, their effectiveness in various forms, and which precautions to take.
One query you may have is what does it mean to take nootropics sublingually? This article will explain this administration technique and tell you how it works.



- Promotes brain health & communication
- Supports memory, reasoning & cognition
- oosts focus, mental clarity & attention
Which Formulations Are Best?
Related Topics
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- Nootropics List
- Types of Nootropics
- Effects & Benefits
- How Do Nootropics Work?
- Natural Nootropics
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- Boost Memory
- Improve Concentration
- Reduce Anxiety
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- Nootropic Side Effects & Dangers
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Nootropics generally come in three different forms. These include pills (or capsules), powders, and oral liquid varieties. (There are also some nasal spray nootropics like Semax, but these are pretty rare at present.)
Each one has their own specific pros and cons.
Pills are probably the most convenient option for many people and is what most people are familiar with from using multivitamins and other supplements. Simply open the packaging, pop one in your mouth, and swallow together with water or some other liquid.
The main downside with pills and capsules as opposed to powders is that they can take longer to work since there is more energy and effort required for digestion and absorption. Pills also lock you in to using whatever dosage is recommended by the manufacturer and do not give you as many personalization options.
Powders and oral formulations both have a number of advantages. Powders are quick to dissolve and absorb much faster into the bloodstream than pills or capsules.
On the other hand, they can be bulky and inconvenient to have to mix them with water, juice, or milk.
Oral varieties such as drops or syrups also dissolve immediately and are absorbed the fastest of all formulations. However, they are not widely available at present and tend to cost more to make.
Nootropic powders tend to be the choice that wins out due to fast absorption and price. Bulk Nootropic powders are by far the cheapest form to purchase supplements like Piracetam or Aniracetam in.

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How to Take Nootropics Sublingually:
Depending on the nootropic powder you are using, it may be recommended that you administer your dose sublingually.
Sublingual literally translates to below the tongue and all it means is that instead of swallowing your dosage you place it under your tongue. Taking Nootropics sublingually is a very easy process, although it might take some getting used to for those who are pill swallowers or protein drinkers.
All that is needed is to simply place a few drops (depending on the required dosage level) underneath the tongue. It is important not to swallow this, since the whole idea is that it will disintegrate very quickly.
Normally this is reserved for highly concentrated nootropics that you will only need a small dosage of in order to be effective. As you can imagine, placing four grams of Piracetam powder under your tongue might be quite difficult whereas a 40 mg dosage of Noopept is much more feasible!
In order to do this effectively, it is helpful to be in an upright sitting position. Just tilt your head back very slightly and lift the tongue. Carefully placing the appropriate amount underneath your tongue and try to limit disturbing it by moving your tongue around.
You will want to possibly hold your breath for a few seconds while the supplement actually evaporates. Once again, remember to not swallow and do not eat or drink anything. Only after the material has fully been absorbed for a further few seconds should you rinse the mouth out with water.
Note: Some nootropics like Centrophenoxine and Pyritinol can cause painful reactions if placed under the tongue. You may experience discomfort and feel a rash develop as though skin is being peeled away from the bottom of your tongue. While this is not generally a serious problem, it can cause several hours of unpleasant sensations in the mouth.
As such, you should avoid taking nootropics sublingually unless you have heard from other users who have used these supplements in this way without negative side effects.
Sublingual Administration Effectiveness:
The actual supplement is absorbed through the mucous membranes within the mouth. It is then directly transferred to the bloodstream. The entire process is usually very quick, ordinarily taking place within just a few seconds.
This means that it bypasses the stomach and the liver, and the supplement can immediately enter the bloodstream. With most Nootropics the next step is crossing over the blood-brain barrier and entering the central nervous system.
The main benefit to this process from an effectiveness standpoint is indeed the speed. The supplement is delivered to its intended target, whether this is a neurotransmitter receptor site, or the grey matter brain tissue, very quickly.
The effectiveness of Nootropics is not really changed, although due to the speed of delivery it can feel like more of jolt to the system.
One interesting point is that nootropics that need to be metabolized by the liver in order to work should not be taken sublingually. However, if a nootropic is known to be harsh on the liver it may help prevent side effects if you take it sublingually as opposed to digesting it through your stomach.
Precautions To Take:
There are few precautions to take before and during sublingual administration. Most of these are common sense, like do not try to eat or drink anything while taking the supplement.
Stop smoking at least an hour before taking the Nootropic. If you are using any other pill or capsule based supplements, take this first.
Make sure it dissolves completely; holding the head slightly forward after placing the medication can help with this (and also ensures no swallowing). Wait at least 30 seconds to a minute before rinsing the mouth out with water. Several minutes would be even better.
Article last updated on: February 23rd, 2018 by Nootriment
1 Comment
It seems to me that acetyl Carnitine would make a v good candidate for sublingual to avoid the production of TMAO in the gut?? Does that make sense to anyone else?