Many people call Ophiocordyceps sinensis the caterpillar fungus. It is a member of the Ascomycetes phylum of the Fungi botanical kingdom.
This parasitic fungus feeds on larva of Lepidoptera butterflies as they hibernate during winter months. It takes over their body cavities and uses them to grow its mycelium. After the host larva dies, the fruiting body (stroma) of the fungus grows out of its head.
This combination of the caterpillar’s carcass plus the mycelium has been used for many centuries in Tibetan, Chinese and certain other eastern medicine systems.
Ophiocordyceps sinensis is considered to be an adaptogen; a natural substance that safely improves systemic health.



- Shown to reduce fatigue & stress
- Anti-oxidant that stimulates the immune system
- Increases testosterone secretion & libido
Ophiocordyceps Sinensis Health Benefits
Related Topics
Preliminary research shows various potential health benefits associated with Ophiocordyceps sinensis.
Taken orally, it is used to strengthen immunity, reduce the effects of aging and improve physical performance. It is believed effective for reducing fatigue, increasing energy metabolism and promoting increased longevity.
Ophiocordyceps sinensis demonstrates multiple therapeutic mechanisms in clinical trials. It seems to affect the cardiovascular, hepatic (liver), renal (kidney), endocrine, nervous and immune systems.
Clinical data also suggests prosexual, hormone-balancing, antidepressant, antioxidant and anti-inflammatory properties.
However, there is limited human research into the effects of Ophiocordyceps Sinensis supplements. Many of its attributed uses are derived from traditional medicine systems or based on folklore and anecdotal evidence.
Ophiocordyceps Sinensis Uses
Preliminary research indicates that O. sinensis may stimulate the immune system by upregulating the number of helper T cells. Further it is believed to support immunity by increasing the activities of NK (natural killer) cells.
O. sinensis stimulates mononuclear cells in the blood. It increases amounts of TNF (tumor necrosis factor)-alpha, interferon-gamma and interleukin-1. It is also known to prolong survival of lymphocytes.
Research on Ophiocordyceps sinensis anticancer effects suggests that it strengthens immunity responses, decreases tumor size and increases the length of survival.
There is evidence that O. sinensis induces cytotoxicity in cancerous cells. To date, it seems particularly effective for carcinomas in lungs, and melanomas (skin cancers).
Preliminary research shows that O. sinensis may upregulate cellular immunity and increase life quality in those undergoing radiation and/or chemotherapy treatments. Taking this supplement in conjunction with these treatments may improve the patient’s tolerance.
Some research suggests that Ophiocordyceps sinensis can reduce the risk of renal toxicity, especially when induced by aminoglycoside antibiotics and/or immunosuppressant drugs like cyclosporine. This may be beneficial for those with chronic renal failure conditions.
There is evidence that O. sinensis can inhibit thrombus formations and platelet aggregation. It also helps to reduce low density lipoprotein cholesterol (LDL-C) and triglycerides.
Further, it seems to have benefits for the cardiovascular system. In some studies, it has been found to reduce heart rate and cardiac workload.
Polysaccharides in Ophiocordyceps sinensis may help to reduce blood glucose levels and increase the production of corticosterone. It does so without causing reductions of plasma insulin. O. sinensis may help to naturally modulate blood glucose levels and increase insulin sensitivity.
Ophiocordyceps Sinensis Dosage
Do not begin using Ophiocordyceps sinensis supplements before first consulting with a doctor to determine whether this product is appropriate for you.
Human clinical studies have used daily doses between 1000 mg and 3000 mg. This dosage range has yielded health benefits and is not associated with adverse effects.
Optimal dosage levels have not been established for any given conditions. Different Cordyceps supplements may contain different dosages of active ingredients. For this reason, it is important to follow dosage guidelines for the specific product you are using.
Ophiocordyceps Sinensis Side Effects and Interactions
O. sinensis caterpillar mushrooms are generally well-tolerated in healthy adults. Regular usage is not associated with any serious adverse effects.
When side effects occur, the most common are dry mouth, nausea and diarrhea. These effects pass quickly without intervention.
There have not been any gold standard human trials conducted to discern the full scope of O. sinensis effects and side effects.
Most information concerning adverse effects has been gained from users reports. Traditional cross cultural use of Ophiocordyceps sinensis for centuries also demonstrates its safety.
It is best to speak with a doctor before beginning to use an O. sinensis supplement. Possibilities exist for interactions with various medications, diseases and over-the counter supplements.
Ophiocordyceps sinensis can affect the functioning of the immune system. It is not recommended for use in conjunction with prescription medications which affect immunity; like immunosuppressant drugs.
Also, use this fungus cautiously if you use medications for controlling symptoms of diabetes mellitus. This supplement may cause blood sugar levels to fall too low when combined with hypoglycemic medicines.
Caterpillar mushroom extract supplements are believed to affect multiple survival pathways. Seek medical advice about the benefits, side effects and interactions of O. sinensis as they apply to your unique health state.
Consusions
The long history of O. sinensis usage in traditional medicine makes it a popular modern dietary supplement. Clinical proof of its therapeutic effects is still in preliminary stages. Large-scale, randomized human trials are necessary to validate the health benefits of Ophiocordyceps sinensis.
- Lo, Hui-Chen et al. "A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps Sinensis in Dongchongxiacao (???? D?ng Chóng Xià C?o) and Related Bioactive Ingredients." Journal of Traditional and Complementary Medicine 3.1 (2013): 16–32. PMC. Web. 20 May 2016.
- Panda, Ashok Kumar, and Kailash Chandra Swain. "Traditional Uses and Medicinal Potential of Cordyceps Sinensis of Sikkim." Journal of Ayurveda and Integrative Medicine 2.1 (2011): 9–13. PMC. Web. 22 June 2015.
- Liu Y, Wang J, Wang W, Zhang H, Zhang X, Han C.. The Chemical Constituents and Pharmacological Actions of Cordyceps sinensis. Evid Based Complement Alternat Med. 2015;2015:575063. doi: 10.1155/2015/575063. Epub 2015 Apr 16.
- Lo HC1, Hsieh C2, Lin FY3, Hsu TH3. A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordycepssinensis in Dong-ChongXiaCao ( D?ng Chóng Xià C?o) and Related Bioactive Ingredients. J Tradit Complement Med. 2013 Jan;3(1):16-32. doi: 10.4103/2225-4110.106538.
- Paterson RR. Cordyceps: a traditional Chinese medicine and another fungal therapeutic biofactory? Phytochemistry. 2008 May;69(7):1469-95. doi: 10.1016/j.phytochem.2008.01.027. Epub 2008 Mar 17.
- Lo, Hui-Chen et al. "A Systematic Review of the Mysterious Caterpillar FungusOphiocordyceps Sinensis in Dong-ChongXiaCao (???? D?ng Chóng Xià C?o) and Related Bioactive Ingredients." Journal of Traditional and Complementary Medicine 3.1 (2013): 16–32. PMC. Web. 22 June 2015.
- Yue K1, Ye M, Lin X, Zhou Z. The artificial cultivation of medicinal Caterpillar Fungus, Ophiocordycepssinensis (Ascomycetes): a review. Int J Med Mushrooms. 2013;15(5):425-34.
- Zhou XW1, Li LJ, Tian EW. Advances in research of the artificial cultivation of Ophiocordycepssinensis in China. Crit Rev Biotechnol. 2014 Sep;34(3):233-43. doi: 10.3109/07388551.2013.791245. Epub 2013 Jul 22.
Article last updated on: March 12th, 2018 by Nootriment