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In order to get the best effects from the brain supplement Phenibut, you must choose the best dosage to use.
Phenibut is a naturally derived Nootropic supplement with a lot of positive applications related to improving cognitive function and mood. It is a modified version of the naturally occurring brain chemical GABA.
GABA is an important chemical in the body, known for being the primary inhibitory neurotransmitter found within the brain and central nervous system.
This chemical has the effect of lowering the stimulation level of the brain. GABA causes over-active neurons to reduce their firing rate, having a calming anti-anxiety effect over not only the brain, but the entire body.
Phenibut’s chemical structural is identical to the GABA molecule, but it has an additional phenyl ring added on. This addition does several things to Phenibut, but the main effect is that it enables the supplement to cross over the blood-barrier (BBB). GABA itself does a poor job of crossing the BBB when it is ingested in oral supplement form.
You can think of Phenibut as a high-powered delivery system for GABA, able to produce changes in the central nervous system. Because of the crucial role that GABA plays in the brain, any mistake in your Phenibut dosage quantity or schedule may throw off optimal performance of your cognitive faculties.
Anxiety
Mood
Sleep & Insomnia- Powerful anxiolytic for stress reduction
- Stimulates GABA receptors & supports sleep
- Neuroprotective & supports cognitive function
Phenibut Uses & Benefits
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- Withdrawal Dangers
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Perhaps the most often cited benefits of Phenibut are related to helping one relax and calm down.
Using this supplement may result in lowered levels of stress and fewer anxious thoughts.
It is a generally recognized fact that anxiety is caused by overactive neuron activity caused by overstimulation of certain neural pathways. Phenibut (by virtue of its GABA-like make-up) is believed to have the ability to ‘calm’ excessive neuron firing.
There are some users who report that Phenibut has helped to improve some cognitive abilities. This includes improved memory and an expanded learning capacity, along with the ability to more easily (and more quickly) recall memories and details.
Evidence indicates that this supplement might be able to support improved neuronal communication between both hemispheres of the brain. In many cases this may also lead to improved problem-solving abilities and more creative thought.
Another interesting benefit of Phenibut is improved sleep. Many people take it as a sedative and find that it makes it easier to not only relax but to also fall asleep.
Not only this, but Phenibut may also promote better quality sleep, allowing the user to wake up feeling more rested and refreshed. This could be an alternative to strong sleeping pills, or other unnatural chemicals.
- Powerful anxiolytic for stress reduction
- Improves sleep and may reduce insomnia
- Neuroprotective and cardioprotective effects
Some research also reports that Phenibut may protect the brain and neurons from select forms of damage. According to some definitions, this is one of the things that separates true Nootropic supplements from just cognitive enhancers.
Neuronal cell damage occurs when stress hormones are high and maintenance and repair processes are thrown off. Phenibut may help to relieve this potential for damage by ensuring that stress hormones stay low and that you remain relaxed and calm.
To this end, it may even have the added benefit of helping to protect your heart, by lessening the pressure on the ventricles.
Research on Phenibut is mostly limited to studies done in Russia in the 1960-70s. More current research needs to be done to fully determine the effects of Phenibut. While Phenibut is still used today in Russia as a drug, at this time in the USA the FDA has not approved Phenibut as a drug to prevent or treat any conditions.
Phenibut Dosages & How To Use
Before buying this nootropic, you must remember that Phenibut is a very powerful supplement. Proper care and thought must go into planning your dosage schedule.
Due to the possibility of forming a tolerance to this compound, Phenibut should not be taken on an everyday basis.
You should ideally use it a maximum of twice a week or cycle it with long periods of not using it. This will ensure that your body does not adjust to higher levels of GABA activity which can lead to tolerance or withdrawal symptoms after extensive use.
It is recommended to take between 250 mg to 1000 mg of Phenibut powder or capsules per day. Based on user reports and clinical studies, anywhere from 250 to 3,000 mg per day has been used safely.
Of course, it is always advisable for a new user to begin with their lowest effective dose. This could possibly be even lower than the 250 mg mentioned above. This also allows time for the body to adjust to the higher levels of GABA which are now being supplied.
You can experiment within this range, although going above 1,000 mg per day is generally not recommended. Proceed slowly and carefully observe the effects at lower levels before considering raising your dosage of Phenibut.
Most people will take Phenibut later in the day as opposed to using it during the more productive hours. You should generally not split your dose into smaller administrations. This is due to the fact that Phenibut has a fairly long half life and remains active in the system for the better part of a full day, unlike most other Nootropics.
Phenibut does have a very strong and sour taste, especially in the powdered form. However, it is water soluble so you have a lot of options for administration: mix the powder with water or juice, or even use pills (you could even decide to cap your own pills).
- Most effective supplements to improve mood
- Optimize levels of dopamine, serotonin and GABA
- Protect against stress and anxiety
Phenibut Dosage Chart
This nootropic drug is used medicinally in certain countries to treat conditions including Anxiety, Alcohol Withdrawal Syndrome, Depression, Insomnia, Asthenia, Emotional Lability (Instability) and symptoms such as headaches.
It has also been used in children to treat stuttering and tics, such as those seen with Tourette’s Syndrome. It has further been prescribed in Russia, Latvia and Ukraine for Meniere’s disease, motion sickness, and for patients with cerebral ischemia (stroke).
Medical dosages of Phenibut (sold under the brand name Noofen) should be determined under consultation with a qualified physician. This drug is not appropriate for everyone and different people may require lower or high dosages, depending on the intended use.
According to the patient leaflet provided in Latvia to users of the Noofen medication, the following dosages are recommended to be taken orally after meals and with water.
Asthenia and Anxious-Neurotic States: 250 – 500 mg three times per day. A maximum single dose of 750 mg is recommended for adults under 60 years of age. For elderly patients, the recommended maximum dose is 600 mg. Treatment lasts 2-3 weeks and may be extended to 4-6 weeks under doctor supervision.
Meniere’s Disease and Dizziness: For mild cases, 250 mg is recommended twice per day for the first 5-7 days, followed by a single 250 mg dose per day during the next 7-10 days.
In cases of dizziness due to dysfunction of the vestibular apparatus of an infectious origin or due to exacerbated Meniere’s Disease, a high dose of 750 mg is recommended three times daily for the first 5-7 days, followed by 250 – 500 mg three times per day for the next 5-7 days and finally a single 250 mg dose per day for the last 5 days.
For dizziness due to dysfunction of the vestibular apparatus of a traumatic or vascular origin, a dose of 250 mg is taken orally three times daily for 12 days.
Prophylaxis of Kinetosis (Prevention of Motion Sickness): A single dose of 250 – 500 mg taken one hour prior or at the first signs of nausea.
Alcohol Withdrawal Syndrome: 250 – 500 mg taken three times daily during the initial treatment period with a 750 mg dosage at bedtime. Dosage is gradually decreased as withdrawal symptoms taper off.
Children: In children under 8 years of age, a dose of 125 mg per day is used. For children between 8 – 14 years of age, a dose of 250 mg three times per day is prescribed. Do not give this nootropic drug to children without first consulting a doctor and follow the dosage guidelines provided by your physician.
Dangers & Side Effects
As with all new supplements, it is recommended that you speak with your doctor before beginning use. Your doctor will be able to determine the best dosage for your needs and make sure the new supplement will not negatively interact with any existing supplements or medications.
As with any supplement, side effects are determined by how much is used and exactly how the supplement is used/taken. Phenibut is considered to be safe in lower doses (between 250 and 500 mg).
When taken in higher doses (anything over 2,000 mg per day) it can lead to side effects similar to those associated with GABA stimulators like alcohol and GHB.
These may include fatigue, nausea, light-headedness, headaches, stomach discomfort. More serious side effects – typically only seen if you take an excessively high dose – can include memory loss and unconsciousness.
As mentioned, this nootropic can lead to tolerance fairly quickly so you should be using your Phenibut dosages on an infrequent basis.
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- Zhezlova AV, Belolipetskaia VG, Blagodatskikh SV, Merkulova EV. [Bioequivalence of anvifen and phenibut]. Eksp Klin Farmakol. 2011
- Ostrovskaia RU, Trofimov SS. [Nootropic properties of gamma-aminobutyric acid derivatives]. Biull Eksp Biol Med. 1984
- Ziablitseva EA, Pavlova IV. [Effect of GABA receptor agonist phenibut on behavior and respiration of rabbits in the negative emotional situation]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2007
- Schmitt C, Gégu C, Spadari M, de Haro L. [Use of phenibut in France: report of two cases]. Therapie. 2013
- Allikmets LKh, Riago LK, Nurk AM. [Effect of the GABA receptor blockader bicuculline on the action of fenibut and diazepam]. Biull Eksp Biol Med. 1982
Article last updated on: March 13th, 2018 by Nootriment
1 Comment
Great product, helped with relaxation and reduction of daily benzodiazepine dosage. Used 600 mg. twice a week.