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Phenibut HCL is a nootropic that people use to reduce anxiety, improve sleep patterns, and support cognitive performance.
Phenibut is sometimes sold under the brand name Noofen, Fenibut, Citrocard or Phenybut. It’s chemical name is Beta-phenyl-gamma-aminobutyric acid, and it is a derivative of the neurotransmitter GABA.
Phenibut is a common component of nootropic stacks designed to reduce stress and enhance the mood. It is sometimes used as an anxiolytic by individuals who suffer from social anxiety or even as an anti-depressant.
There are several different beneficial mechanisms of action for Phenibut if it is used properly and at low doses. At higher doses, there is an increased risk of serous side effects.
If it is overused, tolerance and dependence have been reported and withdrawal symptoms can occur when you stop taking it. In this guide, we will take a closer look at Phenibut effects and side effects and how to use it properly.
Anxiety
Mood
Sleep & Insomnia- Powerful anxiolytic for stress reduction
- Stimulates GABA receptors & supports sleep
- Neuroprotective & supports cognitive function
What Is Phenibut HCL?
Related Topics
- What is Phenibut?
- User Review
- Benefits and Uses
- Dosage Recommendations
- Effects & Mechanisms of Action
- Experience Reports
- Anti-Anxiety Effects
- Using Phenibut for Sleep
- How to Take
- Negative Side Effects
- Withdrawal Dangers
- Risks with Alcohol Combination
- Comparison to Picamilon
- Buying Phenibut Guide
- Using Bulk Powder
- Primaforce Phenibut Review
- SNS Phenibut XT Review
Phenibut is a modified version of gamma-aminobutyric acid (GABA) which is one of the inhibitory neurotransmitters in the brain.
It exhibits a relaxing effect and is also describe as producing a euphoriant, dis-inhibiting and calming state of mind.
GABA is naturally released in the brain to promote feelings of calm and relaxation. Supplementing with GABA itself is not effective because this compound cannot penetrate what is known as the “blood-brain barrier.”
The blood-brain barrier is a protective filtration membrane that surrounds the brain and separates it from the bloodstream.
Phenibut is chemically very similar to GABA, however it is able to cross the blood-brain barrier because of the addition of a phenyl group molecule to GABA’s chemical structure. It is hypothesized that using a supplement like Phenibut hydrochloride can replicate some of GABA’s effects within the brain.
This makes it a Gabapentinoid drug, which is a class of medication used for the treatment of epilepsy, neuropathic pain, and restless legs syndrome. Other Gabapentinoids include Gabapentin, GABOB, Baclofen, Pregabalin and Fluorophenibut (Fluorobut, F-Phenibut).
Once Phenibut reaches the brain, it activates GABA receptors on certain synapses between neurons. Phenibut is known as a non-selective GABA agonist because it stimulates two different types of receptors for this neurotransmitter – GABA-A and GABA-B receptors.
You might recognize this as similar to the mechanism of action for alcohol. Alcohol also stimulates GABA receptors to lessen anxiety and stress, relax muscles, reduce inhibitions, and provide a sedative-like effect.
This makes Phenibut different from other nootropic supplements which may provide stimulatory effects.
- Powerful anxiolytic for stress reduction
- Improves sleep and may reduce insomnia
- Neuroprotective and cardioprotective effects
Phenibut Effects
The user-described benefits of Phenibut fall into a few major categories: Anxiolytic, Cognitive, Ataractic, Neuroprotective, and Cardioprotective.
Anxiety is thought to result from not being able to turn off certain types of communication between neurons. If you constantly fixate on small details and cannot seem to quiet your thoughts, then Phenibut might help to reduce some of this over-thinking. When used as an anxiolytic, this supplement may help to alleviate stress and anxious thoughts caused from overactive neural processing.
Many users report that this nootropic supplement makes them feel more composed, serene, and less likely to experience worry cycles. Phenibut HCL may also work to lessen social anxiety and shyness by helping you overcome unnecessary inhibitions.
There is also some limited evidence that Phenibut may increase cognitive abilities and mental performance. According to several trials, taking Phenibut led to improved brain function especially in regards to communication between the hemispheres of the brain.
This type of transcallosal communication is associated with better problem solving skills and more creative thought. Phenibut may support better memory and learning, but research in this area is still limited.
One of the primary reasons people use Phenibut is as a sedative or ataractic agent to improve sleep quality. If you find that you have trouble sleeping at night and do not achieve enough deep sleep, Phenibut may make it easier to fall asleep at night and wake up feeling rested.
Phenibut may also have neuroprotective qualities. Evidence suggests it is able to prevent some of the neuronal cell damage that occurs when stress hormones are high. This is also related to the potential cardioprotective benefits of the drug which may lessen pressure on the ventricles of your heart.
Research on Phenibut use and effects in humans is very limited, and more research is needed. At this time, Phenibut has not been approved as a drug by the FDA to prevent or treat any conditions.
- Most effective supplements to improve mood
- Optimize levels of dopamine, serotonin and GABA
- Protect against stress and anxiety
Phenibut Side Effects
While there are many positive benefits associated with Phenibut, there is also the potential for side effects if it is used improperly. For most adult users, it is safe to use at low dosages; however, exceeding the safe range can cause similar side effects to other GABA stimulators such as alcohol, Benzodiazepines, and GHB.
It is also recommended that you do not combine this supplement with other GABA agonists (also known as GABAergics) like alcohol, because the stacking of these compounds may lead to more serious risks.
Some of the most common side effects seen with Phenibut usage include: fatigue, nausea, lightheadedness, headaches, stomach discomfort, and in more serious cases unconsciousness or memory loss.
It is recommended to only take Phenibut for at most a few weeks at a time. Some users report that tolerance can begin as soon as five days after beginning Phenibut, and increasing the dosage will often only increase the chance of side effects with no increased benefits. There are also some reports of experiencing Phenibut withdrawal online which is why you should not use this product on an ongoing basis.
Phenibut Dosages
As stated above, dosage control is particularly important with a compound as strong as Phenibut. The recommended dosage range is between 250 mg to 1000 mg but you should start with a smaller Phenibut dose and allow your body time to adjust before increasing to the full amount.
This compound has a much longer half-life than other nootropics and the effects can last for a full day. For this reason, you will not want to take more than one Phenibut dosage in a day with at least 4-6 hours between any follow-up administrations.
As an ingredient, Phenibut is most commonly sold in the form of a hydrochloride (HCL) salt. Another option is the free amino acid form (FAA).
The main difference between the two is that Phenibut FAA contains 20% more of the active ingredient in a single dose and has a higher potency. Online reports claim that Phenibut FAA is converted into Phenibut HCL in the gastrointestinal tract and the physiological effects of these compounds are the same.
Some people may experience more stomach-related side effects with one form or the other, but this is subject to individual sensitivities. There are no significant differences between the effects of these two formulations of the nootropic drug.
Phenibut HCL is water soluble and the powdered form of the supplement can be easily mixed into water or juice for ingestion. However, because the powder can taste quite sour many people prefer to cap their own pills after buying the bulk powder which is both cost-effective and convenient.
Legal Status
In the United States, Canada, United Kingdom and Australia, Phenibut is an uncontrolled substance, which means it is legal to possess without a prescription or license.
However, there may be restrictions on the manufacturing, production, importing and sale of this substance. It is not an approved drug by the FDA and cannot be purchased at a pharmacy or over the counter in the USA.
In other countries, particularly Russia and Eastern Europe, it is regulated as a prescription drug and may be available through your doctor.
What is the difference between Phenibut and Flourophenibut?
F-Phenibut is structurally related to Phenibut and has a similar profile of cognitive and physiological effects. However, the onset of this drug is significantly faster than its analog, with greater potency and a shorter duration of effects.
The primary difference is that it has a fluorine-substituted phenyl group in the beta-position of the molecule, making it very similar to the chemical structure of Baclofen.
There is very limited research available on Flourophenibut at this point. According to anecdotal reports, it may produce a greater euphoric effect and may have a higher risk of abuse for recreational purposes.
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- Downes MA, Berling IL, Mostafa A, Grice J, Roberts MS, Isbister GK. Acute behavioural disturbance associated with phenibut purchased via an internet supplier. Clin Toxicol (Phila). 2015
- Samokhvalov AV, Paton-Gay CL, Balchand K, Rehm J. Phenibut dependence. BMJ Case Rep. 2013
- O'Connell CW, Schneir AB, Hwang JQ, Cantrell FL. Phenibut, the appearance of another potentially dangerous product in the United States. Am J Med. 2014
- Bagmetova VV, Krivitskaya AN, Tyurenkov IN. Effects of Phenibut and Citrocard on Non-Competitive and Competitive Behavior during Provoked Aggression in Animals. Bull Exp Biol Med. 2015
- Högberg L, Szabó I, Ruusa J. [Phenibut yielded withdrawal symptoms and psychosis. Drugs for cosmonauts--now marketed as dietary supplements online]. Lakartidningen. 2013
- Schmitt C, Gégu C, Spadari M, de Haro L. [Use of phenibut in France: report of two cases]. Therapie. 2013
- Tiurenkov IN, Volotova EV, Kurkin DV, Litvinov AA, Tarasov AS. [Effect of phenibut and its composition with nicotinic acid on hemostasis in rats with brain ischemia]. Eksp Klin Farmakol. 2012
- Wong A, Little M, Caldicott D, Easton C, Andres D, Greene SL. Analytically confirmed recreational use of Phenibut (β-phenyl-γ-aminobutyric acid) bought over the internet. Clin Toxicol (Phila). 2015
- Perfilova VN, Ivanova LB, Karamysheva VI, Borodin DD. [Effect of new phenibut salts on psychic and physical development of posterity in rats with experimental gestosis]. Eksp Klin Farmakol. 2012
- Tiurenkov IN, Bagmetova VV, Krivitskaia AN, Berestovitskaia VM, Vasil'eva OS. [Psychotropic effect of phenibut salts and their compositions with organic acids]. Eksp Klin Farmakol. 2011
- Tiurenkov IN, Samotrueva MA, Kuleshevskaia NR, Berestovitskaia VM, Vasil'eva OS. [Comparative study of immunomodulating properties of phenibut and gammoxin]. Eksp Klin Farmakol. 2010
- [No authors listed] [Gravidaprotective action of phenibut in experimental pre-eclampsia]. Eksp Klin Farmakol. 2014
- Zhezlova AV, Belolipetskaia VG, Blagodatskikh SV, Merkulova EV. [Bioequivalence of anvifen and phenibut]. Eksp Klin Farmakol. 2011
- Samotrueva MA, Tiurenkov IN, TeplyÄ DL, Kuleshevskaia NR, Khlebtsova EV. [Immune-regulating effect of phenibut under lipopolysaccharide-induced immune stress conditions]. Eksp Klin Farmakol. 2010
- Likhodeeva VA, Spasov AA, Isupov IB, Mandrikov VB. [Effects of phenibut on parameters of cerebral hemodynamics in swimmers with dysadaptation syndrome and various types of systemic hemodynamics]. Eksp Klin Farmakol. 2010
- Ziablintseva EA, Pavlova IV. [Influence of GABA agonist phenibut on the neuronal activity and interaction in hippocampus and neocortex in emotionally negative situations]. Ross Fiziol Zh Im I M Sechenova. 2009
- Magsalin RM, Khan AY. Withdrawal symptoms after Internet purchase of phenibut (β-phenyl-γ-aminobutyric acid HCl). J Clin Psychopharmacol. 2010
- Tarakanov I, Tikhomirova L, Tarasova N, Safonov V, Bialkowska M, Pokorski M. GABA representation in hypoxia sensing: a ventilatory study in the rat. J Biol Regul Homeost Agents. 2011
- Grinberga S, Zvejniece L, Liepinsh E, Dambrova M, Pugovics O. Quantitative analysis of phenibut in rat brain tissue extracts by liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2008
- Dambrova M, Zvejniece L, Liepinsh E, Cirule H, Zharkova O, Veinberg G, Kalvinsh I. Comparative pharmacological activity of optical isomers of phenibut. Eur J Pharmacol. 2008
- Borodkina LE, Molodavkin GM, Tiurenkov IN. [Effect of phenibut on interhemispheric transmission in the rat brain]. Eksp Klin Farmakol. 2009
- Borodkina LE, Kudrin VS, Klodt PM, Narkevich VB, Tiurenkov IN. [Effect of phenibut on the content of monoamines, their metabolites, and neurotransmitter amino acids in rat brain structures]. Eksp Klin Farmakol. 2009
- Tyurenkov IN, Samotrueva MA. Comparative study of immunocorrective activity of phenibut and its organic salts in experimental immunodeficiency. Bull Exp Biol Med. 2009
- Perfilova VN, Sadikova NV, Berestovitskaia VM, Vasil'eva OS. [Cardioprotective properties of new glutamic acid derivative under stress conditions]. Eksp Klin Farmakol. 2014
- Lapin I. Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug. CNS Drug Rev. 2001
- Volotova EV, Kurkin DV, Mazina NV, Berestovitskaia VM, Vasil'eva OS. [Comparative analysis of action of beta-phenyl derivatives of glutamic and gamma-aminobutyric acid on cerebral blood flow and cerebrovascular endothelium after irreversible occlusion of the common carotid artery]. Eksp Klin Farmakol. 2013
- Zyablitseva EA, Pavlova IV. Effects of the GABA receptor agonist phenibut on behavior and respiration in rabbits in emotionally negative situations. Neurosci Behav Physiol. 2008
- Tarakanov IA, Tarasova NN, Belova EA, Safonov VA. [Effect of phenibut on the respiratory arrest caused by serotonin]. Eksp Klin Farmakol. 2006
- Ziablitseva EA, Pavlova IV. [Effect of GABA receptor agonist phenibut on behavior and respiration of rabbits in the negative emotional situation]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2007
- Shul'gina GI, Petrishcheva AP, Kuznetsova GG. [Effect of a derivative of GABA, phenibut, on behavior and the activity of visual cortex neurons of the rabbit during elaboration of a defensive reflex and internal inhibition]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1985
- Gol'dblat IuV, Lapin IP. [Phenibut potentiation of the therapeutic action of antiparkinson agents]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1986
- Komissarov IV, Abramets II. [Ionic mechanisms of the effects of phenibut and GABA unrelated to changes in the function of chloride channels]. Neirofiziologiia. 1985
- Shul'gina GI, Ziablitseva EA. [Effect of the GABA derivative phenibut on learning]. Vestn Ross Akad Med Nauk. 2005
- Tiurenkov IN. [Hemodynamic mechanism of the hypotensive action of beta-phenyl-GABA esters (phenibut)]. Farmakol Toksikol. 1983
- Ziablintseva EA. [The effect of GABA derivative phenibut on defensive conditioning and internal inhibition]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2006
- Tiurenkov IN, Voronkov AV, Borodkina LE. [Effect of phenibut on the behavior of experimental animals under conditions of voluntary chronic alcoholism]. Eksp Klin Farmakol. 2005
- Tiurenkov IN, Bagmetov MN, Epishina VV, Borodkina LE, Voronkov AV. [Comparative evaluation of the neuroprotective activity of phenibut and piracetam under experimental cerebral ischemia conditions in rats]. Eksp Klin Farmakol. 2006
- Kovalev GV, Spasov AA, Bogachev NA, Petrianik VD, OstrovskiÄ OV. [Role of the GABAergic system in the mechanism of the stress-regulating action of phenibut]. Biull Eksp Biol Med. 1987
- SkibitskiÄ VV. [Effect of phenibut and eglonyl on frequency of tachyarrhythmia paroxysms and central hemodynamics in patients with neurocirculatory dystonia]. Vrach Delo. 1983
- Ziablitseva EA, Shul'gina GI. [Peculiarities of nootropic effect of phenibut]. Zh Nevrol Psikhiatr Im S S Korsakova. 2006
- Makarov VI, Tiurenkov IN, Klauchek SV, NalivaÄko IO. [Effect of phenibut, obsidan and their combination on the human functional state in hyperthermia]. Fiziol Cheloveka. 1998
- Tarakanov IA, Safonov VA. [The effect of phenibut on formation of respiratory rhythm]. Biull Eksp Biol Med. 1995
- Zyablitseva EA, Kositsyn NS, Shul'gina GI. The effects of agonists of ionotropic GABA(A) and metabotropic GABA(B) receptors on learning. Span J Psychol. 2009
- Kovalev GV, Morozov IS. [Effect of gamma-aminobutyric acid and phenibut on the central links of the vascular reflexes with chemo- and mechanoreceptors of the aorto-carotid zone]. Biull Eksp Biol Med. 1975
- Zavadenko NN, Suvorinova NIu. [The results of the pharmacological treatment of attention deficit hyperactivity disorder: evaluation with neuropsychological methods]. Zh Nevrol Psikhiatr Im S S Korsakova. 2014
- Chutko LS, Surushkina SIu, Iakovenko EA, Nikishena IS, Anisimova TI, Bondarchuk IuL. [Cognitive and emotional impairments in patients with protracted anxiety-phobic disorders]. Ter Arkh. 2014
- Tyurenkov IN, Perfilova VN, Popova TA, Ivanova LB, Prokofiev II, Gulyaeva OV, Stepa LI. Changes in oxidant and antioxidant status of females with experimental gestosis under the effect of GABA derivatives. Bull Exp Biol Med. 2013
- Samotrueva MA, TeplyÄ DL, Tiurenkov IN, Luzhnova SA. [Changes in the psycho-emotional state under conditions of suppressed immunogenesis, the correction of the disorders with GABA-positive means]. Ross Fiziol Zh Im I M Sechenova. 2010
- Abramets II, SamoÄlovich IM. [Analysis of the nature of responses of neurons of rat spinal ganglia evoked by the activation of GABA-B receptors]. Fiziol Zh SSSR Im I M Sechenova. 1989
- Kovalev GI, Prikhozhan AV, RaevskiÄ KS. [Presynaptic component in the mechanism of fenibut action]. Biull Eksp Biol Med. 1982
- Tiurenkov IN, Bagmetova VV, Borodkina LE, Berestovitskaia VM, Vasil'eva OS. [Fenibut and its citrate prevent psychoneurological disorders caused by chronic stress (paradoxical sleep deprivation)]. Eksp Klin Farmakol. 2012
- Gracheva SV, Kovalev GV. [Effect of fenibut on cardiac hemodynamics in experimental hypertension from the aspect of age]. Farmakol Toksikol. 1986
- Abramets II, Komissarov IV. [Effect of fenibut on the GABA B receptors of the spinal motor neurons]. Biull Eksp Biol Med. 1985
- Gusel' VA, Smirnov DP. [Peripheral mechanism of the phenomenon of fenibut habituation]. Farmakol Toksikol. 1980
- Lapin IP. [GABA-ergic system in defense against excitatory kynurenines]. Vopr Med Khim. 1997
- Lapin IP. [Differences and similarity in the interaction of fenibut, baclofen and diazepam with phenylethylamine]. Farmakol Toksikol. 1985
- Makarov VI, Tiurenkov IN, Klauchek SV, NalivaÄko IIu, Antipova AIu. [The enhancement of human thermal resistance by the single use of bemitil and fenibut]. Eksp Klin Farmakol. 1997
- KozlovskiÄ VL. [Experimental study of the antiepileptic activity of fenibut and its combinations with sodium valproate and aminooxyacetic acid]. Farmakol Toksikol. 1988
- Ostrovskaia RU, Trofimov SS. [Nootropic properties of gamma-aminobutyric acid derivatives]. Biull Eksp Biol Med. 1984
- Erofeev NP, Kovalev GV, Ivanova NA, Orlov RS, Shebeko LV. [Effect of gamma-aminobutyric acid and its analogs on the smooth muscle of veins]. Biull Eksp Biol Med. 1980
- Novikov VE, Naperstnikov VV. [The effect of fenibut on the ultrastructure of the brain mitochondria in traumatic edema and swelling]. Eksp Klin Farmakol. 1994
- Sizov PI, Iasnetsov VS. [Effect of gamma-aminobutyric acid and its agonists on uterine contractile activity]. Farmakol Toksikol. 1988
- Kovaleva EL. [Comparative characteristics of the nootropic action of fenibut and fepiron]. Farmakol Toksikol. 1984
- ZharkovskiÄ AM, Zharkovskaia TA. [Antiabstinent action of fenibut and baclofen on a model of abstinence induced by the benzodiazepine receptor antagonist CGS 8216 in rats receiving diazepam]. Biull Eksp Biol Med. 1987
- Talalaenko AN, Pankrat'ev DV, Goncharenko NV. Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety. Neurosci Behav Physiol. 2003
- Novikov VE, Chemodurova LN. [The effect of GABA-ergic agents on the blood electrolyte balance in acute craniocerebral trauma]. Eksp Klin Farmakol. 1992
- Novikov VE, Sharov An. [The effect of GABA-ergic agents on oxidative phosphorylation in the brain mitochondria in traumatic edema]. Farmakol Toksikol. 1991
- SkoromnyÄ NA, Beketov AI. [Changes in the cerebral hemodynamics under the influence of piracetam and fenibut during motion sickness]. Farmakol Toksikol. 1991
- Talalaenko AN, Zin'kovskaia LIa. [Characteristics of the anxiolytic action of benzodiazepine and GABA derivatives on experimentally modelled anxiety states]. Farmakol Toksikol. 1988
- Danilin VP, Krylov EN, Magalif AIu, Rait ML. [Effect of fenibut on the nocturnal sleep of patients with the alcoholic abstinence syndrome]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1986
- Iasnetsov VS, Evseev AV, Gukasov VM, Matiushin AI. [Comparison of the antioxidative activity of fenibut, fentolamin and ionol]. Farmakol Toksikol. 1990
- Iasnetsov VS, Novikov VE. [The GABA-ergic system and brain edema]. Biull Eksp Biol Med. 1985
- Kuchkarov UI, Ashurov ZSh, Sultanov ShKh. [Efficiency of noophen in heroin addiction]. Lik Sprava. 2009
- Likhodeev VA, Spasov AA, Isupov IB, Mandrikov VB. [Effects of aminalon, fenibut, and picamilon on the typological parameters of cerebral hemodynamics in swimmers with dysadaptation syndrome]. Eksp Klin Farmakol. 2009
- Sapegin ID, Beketov AI. [The effect of pikamilon and fenibut on the blood supply of the brain at rest and under gravitational exposures]. Eksp Klin Farmakol. 1993
- Filimonov VG, Sheveleva GA, Strel'chenko NV, Sizov PI, Iasnetsov VS. [Effect of fenibut and seduxen on fetal development in the second half of pregnancy]. Farmakol Toksikol. 1989
- Tiurenkov IN, Sazhin VA. [Effect of gamma-aminobutyric acid analogs on the brain GABA-ergic system participating in cardiovascular regulation]. Farmakol Toksikol. 1986
- SytinskiÄ IA, Kopelevich VM, Nikitina ZS, PolevoÄ LG. [Alcoholic intoxication and the gamma-aminobutyric acid system of the brain in exposure to pantogam and fenibut]. Farmakol Toksikol. 1986
- Riago LK, Sarv KhA, Allikmets LKh. [Effect of multiple daily administration of fenibut and diazepam on GABA and benzodiazepine receptors in the mouse brain]. Biull Eksp Biol Med. 1983
- Riago LK, Nurk AM, Korneev AIa, Allikmets LKh. [Fenibut binding with bicuculline-insensitive GABA receptors in the rat brain]. Biull Eksp Biol Med. 1982
- RaevskiÄ KS. [Neurochemical aspects of the pharmacology of GABAergic substances]. Farmakol Toksikol. 1981
- Sergeev PV, Sizov PI, Dukhanin AS. [Fenibut and fenazepam as potential protectors of pregnancy with a GABA-ergic mechanism of action]. Eksp Klin Farmakol. 1997
- Volkov AE, Kuzam LN, Borsheva AA. [Effect of fenibut on the fetus and newborn infant after the treatment of gestoses]. Akush Ginekol (Mosk). 1989
- Khaunina RA, Lapin IP. [Use of fenibut in psychiatry and neurology and its place among other psychotropic drugs (review of the literature)]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1989
- Petrova EB, Panferova NE. [Effect of fenibut on orthostatic resistance]. Kosm Biol Aviakosm Med. 1983
- Allikmets LKh, Riago LK, Nurk AM. [Effect of the GABA receptor blockader bicuculline on the action of fenibut and diazepam]. Biull Eksp Biol Med. 1982
- Novikov VE, Kozlov SN, Iasnetsov VS. [Effect of benzodiazepine and GABA derivatives on the energy metabolism indices in brain edema]. Farmakol Toksikol. 1984
Article last updated on: March 13th, 2018 by Nootriment
24 Comments
its amazing u only give benifits and no side effects
Hi Tim,
You can learn more about the potential side effects of Phenibut by reading our article at: https://nootriment.com/phenibut-side-effects/
“Some of the most common side effects seen with Phenibut usage include: fatigue, nausea, lightheadedness, headaches, stomach discomfort and in more serious cases unconsciousness or memory loss. There are also some reports of experiencing Phenibut withdrawal online which is why you should not use this drug on an ongoing basis. “
I think it’s “amazing” that you make all these claims and refer to studies, yet have NO CITATIONS. That is the sloppiness and laziest reporting. While some of the information I already know is accurate from supplements that I have read studies on, any new information I will have to search for and find scholarly studies on myself. It takes very little effort to put some citations at the bottom oof each “article”. Jesus, sources?
Thank you for posting cursory info, but when you’re offering medical advice, you are, you need to cite the studies you refer to.
There’s a reference section right above this comment section dumbass
He wrote this 2 years ago, there was most likely no reference section at the time.
Potency wise, how would you compare something like Phenibut to a average dose of a benzodiazepine like 5mg of diazepam? Also, what are the general effects of taking Phenibut while being treated with a benzodiazepine like diazepam? I have been on various benzodiazepine drugs for anxiety and am interested to see whether Phenibut is a possible healthier alternative to diazepam?
I made a post below that addresses all this. I was on benzos for 7 plus years and Phenibut works better in many ways.
I have been taking Phenibut for about 2 months and used to take Xanax .5 mg twice a day for generalized anxiety disorder and Ambien 10mg for sleep at night. I can definitely say that Phenibut works just as well without the fatigue and brain fog of benzos and hypnotics. My life has improved drastically on it. The anxiety relief is wonderful and my mood is better… I’ve even been dieting and exercising. As for withdrawal associated with it, I started at 1g 2 times a day and found that my baseline is best at 2g 2 times a day with a couple day break every week. Aside from a little lightheadedness and a couple headaches I have had no issues. I can say it is much better than withdrawing from Ambien or Xanax… much much better. I recently read a study that people who take sleeping pills are 5 times more likely to die in their sleep and that people who take benzos are 3 times more likely to develop dementia. Phenibut improves cognitive function, there have been no reports of overdose or death and gives you excellent, sound sleep without grogginess when you wake up. I recommend based on my experience.
Is it safe to use phenibut while using marijuana ?
Jeg har taget phenibut og vil nu gerne ud af det – meeen synes det er rigtig svært da jeg bliver helt skør oven i hovedet – kan ikke sove – er total rastløs – og fået angst.
Er der nogen der ved noget om hvordan man kommer ud af det på en god måde
Kh Jeanne
Phenibut is a great compound. You can find more information at peaknootropics.com/shop/phenibut. I personally like to use 500mg it is less inhibiting and still have great effects for anxiety. Some people use higher dosages but this are more inhibiting and dangerous. Using within the recommended dosage is best and only a few time per week. It can be addictive so best to avoid its use everyday and do no mega-dose. If you do this for anxiety too frequently you are likely to experience some rebound anxiety. Just a warning to everyone looking into phenibut. It is a great product if used correctly. Also do not mix with alcohol as this will only exuberate all the bad effects.
`i was scared to take this but i have no regrets. i bought this from a trustworthy website called liftmode.com. I bought phenibut 300mg 150 capsules at first and when i felt it wasnt kicking in fast enough i bought phenibut fine powder 200grams. it kicks in much faster outside the capsule.it tasye horrible but i found out that milk mask the taste. Before i bought this product i was heavily depressed ,suffered from anxiety and did not adventure out from the fear of being overwhelmed . I usually went out on saturdays but only with close friends and even those interactions were often limited . my life was left at a stand still and my illness(i suffer from syncope as well) was stopping me from being the person i wanted to be Fast forward to now .I’m a lot more social . i can freely hang out with friends or go to interviews with out feeling overwhelmed . my romantic life is becoming a lot more better with my partner for 8 years . he also takes it and agrees that this method helps him feel the full effects. i share this with all my friends in substitute for alcohol and other substances because it naturally improves their well being .we lost all desire to get high and feel this is a much better feeling. if i might also add it improves your sex life by a ton.my epilepsy and panic attacks are minimal as of now and i sleep like a baby.all my friends are buying it for midterms. i recommend this to absoulutely everyone . click the link below. you wont regret it and have nothing to lose!!!!
liftmode.com/phenibut-300mg-c apsules-99-8-pure.html#product_tabs_description_t abbed
liftmode.com/phenibut-crystal-granules-200-grams-7-05-oz-99-8-pure.html
The good thing that Phenibut is really working almost for everyone, and doesn’t take much time to act like racetams. But the problem is, many people misuse it and face withdrawals. Many suppliers sell up to 1kg of Phenibut, while offline pharmacies in it’s country of origin sell only 5gram packs. The possibility of purchasing such enormous amount of Pheni increase its abuse potential.
However, Phenibut is an excellent anxiolytic, way safer than benzos. Also useful for athletes.
Ottimo prodotto assomiglia pregabalin 800 mg 1 grammo….
I took phenibut hoping it would help with my anxiety. To be cautious I only took 125mg. It took about 5 hours and I was disoriented, couldn’t speak, started vomiting then collapsed. I was rushed to hospital put on a ventilator and was in a coma for 3 days.
When I woke up I thought I was dead and had horrific hallucinations. It took me a while to get back to normal
I don’t know why it affected me this way, I had never had it before and wasn’t taking any other drugs or alcohol.
Am I the only one?
You have got to be kidding. Really!?
Sounds to me like you had some alcohol in your system from the night before or mix some meds with it you didn’t know about. Stuff lingers in your system for days. Have you had any experience with Opioides at all?
In a comma? Dude, if you aren’t tolling then this is kinda serious. Well you know to stay away from it then…
Original Russian or Latvian stuff is still the best. Together with adaptol, which is one of the very few relaxants which are not habit forming, they have a very nice, calming, yet leaving-you-all-sharp effect. Avoid meds obviously, but if you are looking for some sort of alternative to classical benzos this is the one.
I like this supplement it’s making me feel great relieves my stress and anxiety better then Xanax. I haven’t been able to really sleep that much on it. When I do finally go to sleep I wake up yelling and feeling *weird *and clinching . I like this supplement but need to discover what is causing this. I have a high caffeine intake. Rarely smoke marijuana on this and it is wonderful combination. But this side effect is always there. Does anyone else that uses this supplement have this effect and if so do you have a high caffeine intake. Sorry for the repost needed to correct autocorrect
common sense!
Incorporate a little critical thinking into your thought processes.
High caffeine intake.Maybe just maybe it could be the caffeine that is causing the insomnia.Dahhhhhhhh.
Sorry for all this I just read the size of the scoop they gave me for dosage so as it turns out I have been taking 3 or 4 times the dosage per day for a week. I guess I just need to ride it out?
Your product is now part of the new street drug rage. My sister just recently overdosed on this product and is still uncontious allthough this is her fault, you should be aware of how dangerous your product is.
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Whoops. Did I say that out loud?