- PhenylethylamineDopamine PrecursorMoodEnergyFat Loss
How It Works:
Top Phenylethylamine Products* ❯View User Ratings* ❯*Affiliate LinksOVERVIEW: Phenylethylamine (PEA) is a chemical found in all mammals that functions as a neurotransmitter. It is chemically similar to amphetamine, and therefore also works as a stimulant. READ MORE...USED FOR: Athletic performance, Depression, Weight loss, Mood, Attention.MECHANISM: Phenylethylamine supplements reduce the uptake and increase the release of various neurotransmitters – specifically serotonin, dopamine, and norepinephrine – which can have mood modulation and cognitive enhancement effects. READ MORE...DOSAGE:100-500 mg per day. READ MORE...SIDE EFFECTS: Rated as Possibly Unsafe when used orally unless under medical supervision. At recommended dosage it is normally well tolerated. Side effects can include stimulant effects similar to amphetamine, constipation, headaches, heartburn, dizziness, insomnia, and nausea. READ MORE...INTERACTIONS: Antidepressants (e.g. SSRIs), Desipramine, Dextromethorphan, Meperidine, MAOIs, Pentazocine, Tramadol. May interact with herbs and supplements that increase serotonin levels, including L-tryptophan, 5-HTP, SAMe, and St. John's Wort. Can have interactions with individuals with bipolar disorder or schizophrenia.RELATED SUPPLEMENTS: Mucuna Pruriens, Sulbutiamine, Phenylalanine, Phenylethylamine, 5-HTP, L-Tryptophan, L-Theanine, SAMe, GABA, Inositol, Rhodiola Rosea, St. John's WortTop Phenylethylamine Supplements
- Stimulates the release of dopamine & norepinephrine
- Promotes positive mood & well-being
- Curbs appetite & supports weight loss
Your article suggests that PEA should be taken with an MAO Inhibitor (Hordenine is suggested) and it then goes on to state that PEA should not be taken by anyone currently taking an MAO Inhibitor. It would be good to clear this ambiguity up. Actually, I don’t think Hordenine is an MAO Inhibitor. Often, a true MAO Inhibitor is desirable to take with PEA to truly prolong it’s effects, thus lower doses of PEA may be adequate and this would be more desirable. However, it seems only an MAO-B Inhibitor is necessary for this, and an MAO-A Inhibitor (or non-selective MAOI) unnecessary or undesirable. Hypertensive crisis is one of the two main risks/concern with MAO-A Inhibitors (usually attributed to tyramine intake). PEA can increase blood pressure and heart rate, and I’m not sure if this is potentiated further with the presence of an MAO-A Inhibitor (as MAO-A can also break down PEA). Serotonin syndrome is the second main risk/concern with MAO-A Inhibitors, and PEA may have SSRI effects – I’m not sure if it also has serotonin releasing effects. But importantly, serotonin syndrome may be another risk/concern when taking PEA with an MAO-A. L-deprenyl / Selegiline is a selective MAO-B Inhibitor at low dose, and is often used with PEA, but at higher doses this also has non-selective MAO Inhibition effects, thus also inhibiting MAO-A. So, to sum up, keep selective MAO-B Inhibition low, and keep PEA intake low, and keep an eye on acute cardiovascular effects (get a monitor) if you choose to explore this. Educate yourself about any risks as touched upon above, and also be wary of dependence and tolerance issues with PEA which I have heard can affect many people. Thus the concept of cycling may work well – taking time off, as appropriate. I have never tried either an MAOI-B or PEA so I cannot share any first hand experience, but this is the information I have come across so far. I hope it has been of some help.