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Before taking a lesser known nootropic supplement like Picamilon, you might have a lot of questions about what to actually expect.
As much as research can inform you about the mechanisms of actions and benefits for any compound, anecdotal experience logs are sometimes the best source of information for more qualitative measures of results.
What are some of the typical Picamilon experiences and how will this supplement effect your mood, mental performance and energy levels?
There are many different reasons for taking Picamilon and not everyone’s experience or usage will be the same. But, if you are willing to take this information with a grain of salt, you can learn a lot about how Picamilon might affect you from reading reviews and experience ratings online.
Mood
Anxiety
Sleep- Consists of GABA & Niacin
- Stimulates GABA receptors in the brain
- Promotes mood, sleep & relaxation
What is Picamilon
Related Topics
While there seems to be some disagreement over the exact year that Picamilon was first synthesized, it occurred sometime between the years of 1969 and 1971.
The preliminary research into this supplement was carried out in the Soviet Union, at their All-Union Vitamin Research Institute.
This was part of their vast research program into nutritional supplements, vitamins, and other potentially performance enhancing substances.
Since much of the research into Picamilon has been in Russian, it has taken some time for the West to become aware of this very interesting and unique nutritional supplement. Picamilon is, essentially, a combination of Niacin, which is a member of the B-vitamin family, and GABA, a naturally-occurring amino acid that acts like a neurotransmitter within the brain and body.
What the Russian scientists discovered is that when these two compounds are combined, it creates unique properties which allow the resulting dietary supplement to target activities in the brain that are not possible when taking GABA on its own.
Picamilon Benefits:
One of the primary benefits of this supplement is that it is able to increase the level of blood flow to the brain. This is an even greater increase than what is seen using other common drugs such as Hydergine, Papaverine, and Nialamide.
This increased blood flow and circulation means that more nutrients and resources like oxygen and glucose are delivered to the brain.
The result is an increase in energy metabolism which can lead to heightened alertness as well as baseline improvements in many different cognitive processes.
There are many different brain benefits observed when taking Picamilon powder. Most users experience improved memory and expanded learning capacity.
Picamilon may have a particularly positive effect on executive functions related to attention span and the ability to concentrate and hold large amounts of information in your working memory. Studies show evidence for this supplement being able to enhance overall motivation, planning, and even intelligence.
Another reason for taking Picamilon dosages is to increase GABA neurotransmitter levels in the brain. GABA supplements themselves are ineffective because this brain chemical cannot be transported from circulating blood into brain tissue.
Instead, GABA has to be manufactured in the brain in order for it to have an effect. But if you have low levels of this neurotransmitter, using Picamilon as a source of GABA can help to relax the brain and body.
This neurotransmitter is known to reduce the effects of stress and anxiety. It can induce a feeling of calm energy, allowing for improved focus and productivity. There is no sedative-like side effect with Picamilon, either. Many Picamilon experience logs state that this supplement has helped with depression-like symptoms and has a positive effect on mood in general.
Picamilon Mechanism Of Action:
The primary mechanism of action for Picamilon is that the supplement is literally carried over the blood-brain barrier using niacin pathways. This makes it superior to basic GABA which cannot pass through this physiological barrier.
Studies show that this action happens rather fast, sometimes in as little as 30 minutes. Picamilon works as a vasodilator, opening up the blood vessels within the brain. This provides brain cells with oxygen rich nutrients and materials that improve overall brain health.
Picamilon is also thought to improve the quality of blood vessel maintenance throughout the body. This may be why the supplement is capable of lowering blood pressure. It also works upon the nerves and neurons that influence vascular tone, both sympathetic and parasympathetic.
Picamilon Experience
What do user reports say about the common facets of the Picamilon experience?
Most of the time, the effects of this supplement are felt rather quickly. Users should see some impact within an hour after taking Picamilon. Reports indicate that these effects can last for usually between 4 and 6 hours.
Of course, in other cases, it may require a week or two for the actual chemical to build up within your system and exhibit the benefits you are looking for.
The level of your dose will greatly affect what you feel from Picamilon. Lower doses of 50 mg up to three times per day should result in a mild tranquilizing and mood stabilizing effect. Higher doses, for example going up to 100 mg, three times per day should result in feeling much more energetic and having more stamina.
Cognitive enhancement benefits are cumulative and should be felt within a few weeks of usage.
Most user report that Picamilon is at least as good, or even better than, other medications they have been prescribed for reducing anxiety and depression. The Picamilon experience is described as feeling stress melt away.
At low dosages, most people indicate a notable tranquilizing action and even mood enhancement. Other users, especially those who continue taking the supplement on a continuous basis for weeks to months will end up reporting enhanced cognitive effects.
These include an improved memory, better ability to learn, study, and even recall facts, figures, places, and people. In short, it helps people to think faster and better.
Perhaps the best thing about this supplement is that it is all-natural. While these two compounds may be bonded together synthetically, both are natural ingredients and they do work without causing any serious side effects.
That being said, negative side effects are possible and over time you may develop a tolerance to this drug. The potential for tolerance and withdrawal symptoms is always high when dealing with supplements that influence GABA pathways. For this reason, it is strongly recommended to cycle Picamilon or ideally only use it on an as-needed basis.
Some Picamilon experiences can become negative if you suddenly stop using the supplement after a long period of time. Also remember that you should not be combining this drug with other anxiolytics like Phenibut or medications for mood disorders as they may interfere with the effects of Picamilon.
In general, this supplement is described as safe and effective, but the best strategy is to practice cautious dosage strategies to allow you to continue to benefit from mood enhancing compounds in the future.
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- Mirzoian RS, Gan'shina TS, KosoÄ MIu, Aleksandrin VV, Aleksandrin PN. [Effect of pikamilon on the cortical blood supply and microcirculation in the pial arteriole system]. Biull Eksp Biol Med. 1989
- BasinskiÄ SN, Krasnogorskaia VN, Lenis IuA. [Pathogenetic treatment of central chorioretinal dystrophies with pikamilon]. Vestn Oftalmol. 2001
- Likhodeev VA, Spasov AA, Isupov IB, Mandrikov VB. [Effects of aminalon, fenibut, and picamilon on the typological parameters of cerebral hemodynamics in swimmers with dysadaptation syndrome]. Eksp Klin Farmakol. 2009
Article last updated on: March 13th, 2018 by Nootriment
1 Comment
Does Picamilon work as an agonist at the GABAa or GABAb or GABAp site or all three. If all three then is there more affinity for any one site?