As the rate of ADD/ADHD diagnosis continues to grow in children and adults, the search for effective Adderall alternatives becomes more and more important.
While Adderall is effective in the short-term for reducing hyperactivity and improving attentiveness, it comes with a high risk of side effects and abuse.
Picamilon is a brain supplement that has recently been thrust into the spotlight as a viable replacement for Adderall in the treatment of Attention Deficit Disorder and Attention Deficit Hyperactivity Disorder.
Picamilon enhances focus and attentional control while balancing out several factors related to mood that can exacerbate ADHD or ADD.
It is naturally derived from the nutrients GABA and niacin, is non-addictive, has few known side effects and does not require a prescription in the USA.
How good is Picamilon for ADHD and why does it boost concentration and alertness?



- Consists of GABA & Niacin
- Stimulates GABA receptors in the brain
- Promotes mood, sleep & relaxation
ADD/ADHD and your Brain
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ADHD is a broad condition characterized by difficulty paying attention, hyperactivity, and a lack of impulse control.
Individuals with ADHD typically get distracted easily, have poor short-term memory, have low tolerance and stamina for mentally challenging tasks, are forgetful and may show poor planning skills.
While there is no cure for ADHD, there are treatments that you can use to ensure your brain is better equipped for executive functions related to attentional control, working memory, reasoning, concentration and basic cognitive processing.
Attention is a complex state that requires the coordination of different brain systems, particularly in the anterior cingulate cortex. Many factors can interfere with the neural communication in this part of the brain, such as low blood flow, insufficient neurotransmitter levels as well as less synaptic receptor density.
Excessive activity in other parts of the brain that may be caused by anxiety or stress can also interfere with attentional control, causing you to become distracted, have poor motivation and lose focus.
Depending on the cause of your ADD/ADHD, Picamilon tablets can be an invaluable tool for boosting concentration, mental energy, alertness and working memory capacity.
Picamilon Effects
The nootropic brain-booster Picamilon is a precursor to both GABA and niacin in the brain.
GABA is a neurotransmitter that is part of the hyperactivity feedback loop in the brain as well as controlling anxiety and stress levels. Niacin is a vitamin that improves brain function at a cellular level by increasing cerebral blood flow.
Together, these compounds have been shown to significantly improve neurological function related to focus, memory, alertness, productivity, social adaptation, speech, impulse control and mood.
Unfortunately, no long term studies into the effects of Picamilon on ADHD are available. However, we can make some reasonable conclusions on the basis of other studies conducted into the cognitive enhancement effects this supplements.
It is strongly advised that you consult a medical professional before seeking out picamilon to treat ADHD.
Picamilon for ADHD
Picamilon is predominantly used as an anti-anxiety supplement and mood enhancer because it can increase GABA activity in the brain. When your GABA receptors are stimulated, it produces a feeling of calm by regulating neuronal excitability and stimulation throughout the nervous system.
Alcohol produces some of its relaxation-inducing effects by interacting with GABA (B) receptors also known as metabotropic receptors.
Picamilon has a mood-brightening effect, resulting in feelings of well-being, contentment and overall tranquility. As such, it may help with some of the hyperactivity related symptoms that are linked to ADHD. It can also keep you from being distracted by anxious thoughts and improve your impulsiveness especially in social settings.
Keeping you mellow is only one of the ways in which Picamilon powder works to address symptoms of ADHD. Another effect of Picamilon is that it can increase intracranial blood flow by way of hydrolysing into Niacin.
This supplement is observed to decrease blood vessel tone in the brain which allows a faster rate of blood circulation to your brain cells. Blood carries oxygen and glucose which are the two main components necessary for producing ATP – the type of energy used by all of the cells in your body.
In following, Picamilon can increase energy metabolism in your brain which supports broad-based improvements to your mental performance.
Low blood flow to the frontal area of the brain is a common sign of ADHD and ADD. By counteracting this impairment, Picamilon may be able to address some of the underlying causes for Attention Deficit Disorders.
In studies, patients given Picamilon dosages displayed increased mental activity, better work habits and more attentiveness. Picamilon reviews often say that this supplement makes them feel more energized, driven, clear-headed, organized and focussed.
It is similar to Adderall in that it has somewhat of a stimulant effect, but it lacks the side effects like restlessness, agitation, and the inevitable energy crash that are associated with this ADHD drug. These improvements start to take effect quite rapidly and significant changes were recorded after only a week of use.
In addition to this Picamilon can improve the health, maintenance and growth of your neurons to keep your brain healthy over the long term.
How to Use Picamilon for ADHD
The dosage range for Picamilon powder is between 50 mg to 450 mg per day. In patients with ADHD, it is common to take 100 mg up to three times a day with 4 hours between dosages.
You may find that your personal needs are different and that a smaller or larger dosage is necessary. Picamilon should not be taken too late in the day or it can sometime make it difficult to fall asleep.
This supplement may be more potent if combined in a nootropic stack with other focus boosters like Noopept, Aniracetam, Sulbutiamine, ALCAR, or Alpha GPC. Side effects are rare and Picamilon is not believed to be toxic except at extremely high dosages.
If you do decide to try Picamilon for ADD or ADHD, it is best to speak to your doctor for personalized advise on how to use this supplement as well as safety considerations.
- Kresiun VI, RozhkovskiÄ IaV. [Molecular-biochemical mechanisms of the effects of nootropic agents]. Biull Eksp Biol Med. 1990
- Kuchmerovskaia TM, Parkhomets PK, Donchenko GV, Obrosova IG, Klimenko AP, KuchmerovskiÄ NA, Pakirbaeva LV, Efimov AS. [Correction of diabetic neuropathies using aldose reductase inhibitors and pikamilon]. Vopr Med Khim. 1998
- Matsuyama K, Yamashita C, Noda A, Goto S, Noda H, Ichimaru Y, Gomita Y. Evaluation of isonicotinoyl-gamma-aminobutyric acid (GABA) and nicotinoyl-GABA as pro-drugs of GABA. Chem Pharm Bull (Tokyo). 1984
- VishnevskiÄ EL, Guseva NB. [Validation of the treatment of the neurogenic bladder in children with myelodysplasia using pikamilon]. Urol Nefrol (Mosk). 1998
- Mirzoian RS, Gan'shina TS, KosoÄ MIu, Aleksandrin VV, Aleksandrin PN. [Effect of pikamilon on the cortical blood supply and microcirculation in the pial arteriole system]. Biull Eksp Biol Med. 1989
- Davydova GA, Mukha AI. [Results of the use of vasoactive preparation pikamilon in pigmented retinal abiotrophy]. Vestn Oftalmol. 1995
Article last updated on: March 13th, 2018 by Nootriment