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Over 25 million Americans suffer from some form of anxiety, a mood disorder which can rob you of enjoyment, negatively impact your productivity and even harm your health.
There are many different forms of anxiety, but all share a similar neurological basis of overactivity in certain systems in your brain.
In the presence of some stressful trigger, your neurons begin to fire excessively, interrupting the normal patterns of communication in your brain.
Anxiety is naturally controlled by the release of the neurotransmitter GABA in the brain which quiets these overstimulated circuits and calms the mind. But in patients with anxiety, it is sometimes necessary to increase GABA levels in the brain to compensate for a deficit.
Picamilon is a modified GABA compound that is known to specifically target the brain and reduce feelings of anxiety. Using Picamilon for anxiety is considered both safe and effective and it may have additional cognitive benefits that make it superior to the more frequently prescribed anxiety drugs.
Mood
Anxiety
Sleep- Consists of GABA & Niacin
- Stimulates GABA receptors in the brain
- Promotes mood, sleep & relaxation
Picamilon for Beginners
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Picamilon is a derivative of GABA with the addition of a Niacin or Vitamin B3 molecule.
It was invented as a way to increase GABA levels in the brain since simply giving a GABA supplement to someone will not actually result in the active ingredient reaching your brain.
The presence of Niacin means that more of Picamilon gets to your cerebrum where it can hydrolyze into GABA and interact with anxiety-causing pathways.
This nootropic is not a cure for anxiety, but it can inhibit its onset and lessen symptoms. The Picamilon experience is typically described as a relaxed, feel-good state of mind without the drowsiness that is caused by many anxiety medications.
It has been used for several different medical conditions such as migraines, asthenia, depression, dementia, ADHD and other forms of cognitive impairment. In some countries, Picamilon is prescribed to treat anxiousness, phobias, mood disorders and social anxiety.
However, in the USA and Canada it is not regulated as a prescription drug and is legal to buy in supplement form. You can purchase it over the counter in either pill or powder format with the bulk Picamilon powder costing as little as $0.20 per dosage.
It is frequently combined in a “nootropic stack” with other anxiety-eliminators like Aniracetam, Noopept, Sulbutiamine, Adrafinil and Choline.
Does Picamilon Work for Anxiety?
Picamilon by itself is an inactive compound until it reaches your brain where it is converted into the neurotransmitter GABA and the vitamin Niacin. Both of these substances can offer benefits for temporary relief from anxiety.
GABA is the major inhibitory neurotransmitter in the Central Nervous System, use to counterbalance the effects of excitatory transmitters like glutamate and noradrenaline.
GABA is frequently released as part of a negative feedback loop when certain neurons detect an excessive rate of stimulation (one of the signs of anxiety).
Picamilon has a fairly straightforward anxiolytic mechanism of action, by activating GABA receptors so that your neurons are less likely to become over-excited. The result is a feeling of calm and what many say is a “positive buzz”.
What makes Picamilon different from Phenibut and many other anti-anxiety drugs is that it does not lead to the characteristic feelings of sedation, lethargy or muscle incoordination. Picamilon supplements can actually have a positive effect on mental energy levels, leading to greater vigilance and acuity.
Users who take this nootropic say that it gives them better focus, improves memory performance and can make it easier to study, read or write for extended periods of time. This is attributable to the presence of Niacin in the Picamilon formula.
Niacin is a cerebrovasodilator which increases blood, oxygen and glucose circulation to the brain. In addition to having benefits for brain health, Niacin is a moderate cognitive enhancer that can contribute to higher fluid intelligence as well as productivity.
Picamilon Side Effects
How do the side effects of Picamilon compare to those associated with other anxiolytic compounds like diazepam or Phenibut?
At present, Picamilon is viewed as much safer and there are relatively few side effects reported with this supplement.
Research studies have identified some mild negative effects, but these are rare and so far no serious adverse events have been reported. Picamilon side effects can include nausea, headaches, dizziness, difficulty falling asleep, restlessness, and in some cases fatigue.
It also has the effect of lowering blood pressure, but many view this as a positive impact as opposed to a negative.
There have been some concerns voiced about Picamilon being a mild Monoamine Oxidase Inhibitor (MAOI), but the risk is still considered very low. You may not want to combine Picamilon with other MAOI’s you are currently taking (such as some medications for depression or other conditions).
Conclusion
Taking Picamilon for anxiety can help you reduce the frequency of anxious thoughts while enabling you to relieve stress and tension. Picamilon can curb excessive worry and be used to overcome irrational fears.
Some users find it to be especially well suited to improving social anxiety symptoms and sociability in general. It works to promote better communication in the brain and has several “smart drug” benefits.
This anxiolytic nootropic might not be powerful enough to deal with serious panic attacks or cases of anxiety disorder, but it does work well for moderate symptoms and on a preventative basis.
You can buy Picamilon as a single ingredient product and use it in dosages of between 50 mg to 450 mg per day. Check with your doctor to determine the best dosage for addressing your anxiety as well as other strategies that can help with this condition.
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- LogaÄ IM, Leus NF, Rozanova ZA. [The characteristics of the retinal absorption of labelled preparations of pikamilon and GABA]. Fiziol Zh. 1991
- Cui W, Chen X, Zhan Y, Zhang Z, Zhang Y, Zhong D. Determination of picamilon concentration in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010
- Dorofeev BF, Kholodov LE. [Pikamilon pharmacokinetics in animals]. Farmakol Toksikol. 1991
- Silkina IV, Gan'shina TC, Seredin SB, Mirzoian RS. [Gabaergic mechanism of cerebrovascular and neuroprotective effects of afobazole and picamilon]. Eksp Klin Farmakol. 2005
- Akopian VP, Balian LS, Avetisian NA. [The effect of hypokinesia on depression and on the central GABA-A receptor complexes in the rat brain]. Eksp Klin Farmakol. 2006
- Kuchmerovskaia TM, Parkhomets PK, Donchenko GV, Obrosova IG, Klimenko AP, KuchmerovskiÄ NA, Pakirbaeva LV, Efimov AS. [Correction of diabetic neuropathies using aldose reductase inhibitors and pikamilon]. Vopr Med Khim. 1998
Article last updated on: March 13th, 2018 by Nootriment