Picamilon is a nootropic used for stress relief, improved mental performance, and anti-aging effects.
Reviews often describe Picamilon as providing a stimulated calm feeling, which makes sense given that it was created by combining GABA and niacin.
The chemical structure of Picamilon is 4-(pyridine-3-carbonylamino)butanoic acid or nicotinyl-y-aminobutyric acid and it was developed in 1969 by the All-Union Vitamins Scientific Research Institute in the Soviet Union.
It is used widely in Russia for many different medical purposes such as treating stroke victims, depression, asthenia, migraines and types of glaucoma.
Most nootropic users are interested in buying Picamilon to boost their mood, alleviate stress and improve cognitive energy and focus.



- Consists of GABA & Niacin
- Stimulates GABA receptors in the brain
- Promotes mood, sleep & relaxation
How Does Picamilon Work?
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Picamilon is transported across the blood-brain barrier by a special niacin analog pathway.
It is then hydrolyzed (reacted with water) and broken down into the neurotransmitter GABA and niacin. From here, the effects produced by Picamilon are typical of higher levels of GABA and niacin.
GABA is considered an inhibitory neurotransmitter, used by your brain to promote relaxation and prevent over-stimulation. These effects are described as anxiolytic meaning that they reduce anxiety and stress.
Many people experience a tranquil and easy-going state of mind when taking GABAergic compounds like Picamilon. You may also feel a lowering of inhibitions which inhibit feelings of social anxiety.
Picamilon is reported to help switch off some of the incessant “mind chatter” or background noise in the brain that can disrupt thought patterns and prevent you from being able to focus.
As a niacin precursor, Picamilon may also contribute to improve energy metabolism in the brain and support neuron health. Niacin is part of the vitamin B complex and it has a number of functions in both the nervous system as well as the gastrointestinal tract.
Niacin’s primary cognitive effect is as a cerebral vasodilator which means it increases blood circulation to the brain. By delivering more oxygen, glucose and other nutrients to the brain, Picamilon via niacin can result in higher levels of alertness and greater concentration and mental stamina.
Overall brain function may be enhanced because this increase in blood flow can lead to better energy metabolism in your brain cells. Furthermore, Picamilon is reported to have a detoxifying effect on neurons because better blood flow means more of the toxins that build up in your cells are being removed at a faster rate.
Picamilon Benefits
The benefits of Picamilon may help individuals with anxiety, depression, sleep disorders or other mood disorders. Picamilon is used by individuals who who want to increase focus and mental energy without higher levels of anxiety.
Many people use Picamilon to help them overcome stress and shyness in social settings. It is reported by some to help stop you from dreading these kinds of interactions by lowering inhibitions.
This nootropic is most often compared to Phenibut which is also a GABAergic anti-anxiety supplement, but the biggest difference is that Phenibut has a sedative effect whereas Picamilon does not.
Picamilon Side Effects
Picamilon is well tolerated by the majority of people but in some rare cases it has been known to cause allergies and skin rashes. Other side effects are generally mild such as lightheadedness, headache, nausea, irritability, low blood pressure, and red flushing of the skin.
There have been no recorded cases of overdose, but you should never exceed the recommended dosage as this may worsen any potential risk of side effects.
You should check with your doctor before using Picamilon with any other medications or anti-anxiety supplements, especially other compounds that work on the GABA receptors.
Suggested Dosage
The suggested dose for Picamilon ranges greatly depending on your individual needs and purpose for using this supplement.
If you are taking the supplement for mood boosting and energy support, manufacturers generally recommend taking 50 – 100 mg per day. For anxiety and stress relief, a larger dosage of 100 – 200 mg per day may perform better, but speak to your doctor to determine the correct dosage.
Picamilon is considered safe for daily use, but you may decide to cycle this supplement or only use it when needed to ensure that you do not form a tolerance to the effects of the nootropic.
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Article last updated on: March 13th, 2018 by Nootriment
3 Comments
Picamilon is great if you suffer from headaches or migraines. It helps ease stress and anxiety and calms you down. Like a valium but without the side effects. It has been a great alternative to going to a doctor for me!
Get your picamilon while you can. FDA is taking it away from us. Producers of picamilon and big chain retailers are getting letters from Big Brother FDA to stop making or selling any products containing picamilon.
http://www.fda.gov/Food/DietarySupplements/QADietarySupplements/ucm472881.htm
Please I want to sell this link treatment and shipped to Saudi Arabia