Piperine is a component of some nootropic stacks, working to intensify the effects of other smart drugs while also offering independent cognitive enhancement benefits.
This supplement has been found to boost memory function, improve mood, and heighten attention and reasoning skills.
Piperine is an organic compound and nutritional supplement that may be classified as either a lipid family member, or an alkaloid (a family of nitrogenous compounds that have marked physiological properties). It is also one of the sharp-tasting constituents of the fruit of the pepper vine (Piper nigrum). In fact, this extract is what gives peppers their spicy taste and it also helps to increase the absorption of a variety of nutrients.
Piperine constitutes between 5 and 9 percent of commercial black or white pepper and is usually combined with the compound chavicine, a geometric isomer. This supplement has been used in some forms of traditional medicine (such as in Ayurvedic practices) to treat gastrointestinal distress, pain, inflammation, and other disorders.
The supplement was discovered in 1819 when it was isolated from the fruits of the Piper nigrum plant. Interestingly enough, this plant is the source of both the black and white pepper grains.



- Improves absoprtion of certain compounds from gut
- Supports digestive health & slows transit times
- Promotes joint comfort & functionality
Piperine Effects:
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One of the most interesting effects of Piperine is that of helping to increase the absorption of a number of other nutrients.
Not only does it increase their absorption, but it also serves to enhance the bioavailability of these supplements.
As an example, studies have demonstrated that it helps to increase the absorption of CoQ10 by around 30 percent, but it also enhances the bioavailability of this supplement by as much as 20 times.
Another interesting aspect to Piperine is its apparent thermogenesis effects. Normally this would be something which was associated only with weight loss, but Piperine does seem to play a vital role in helping the body to utilize the food consumed each day.
In other words, it helps to spark or speed up the metabolism and metabolic processes, providing a more efficient mode of nutrient transportation to the blood. It is even thought to help in a number of seemingly unrelated processes like reducing pain, inflammation, and possibly even combating arthritis.
There are several published studies that have looked at the effects of Piperine on cognitive processing. One study in the Journal of Traditional Medicine found positive impacts from the use of this supplement on memory and behavior metrics.
This performance increase seems to be mediated by monoamine neurotransmitters, suggesting that Piperine acts in a similar way to Monoamine Oxidase Inhibitors. The result is higher levels of Dopamine and Serotonin activity, leading to diverse improvements in mental abilities and factors related to mood.
Piperine Benefits:
The primary benefit of Piperine is improving the absorption of nutrients from the intestines. This benefit is actually known as ‘bio enhancement.’
Although there are certainly a number of other nutrients and material which Piperine is helpful at improving the absorption of, it has been studied and shown to help with vitamin C, selenium, beta-carotene, vitamin A, vitamin B-6, and CoQ10 (coenzyme Q 10).
It is also thought to be useful in other states of malabsorption and malnutrition. Nootropic reviews from Modafinil, Racetam and Noopept users typically say that Piperine multiplies the benefits of these compounds on brainpower.
Piperine may also function as an immunomodulator. In other words, when the primary immune system malfunctions, this supplement takes over and helps to decrease the general inflammatory response. It is thought that this works by decreasing the communication of lymphocytes in the immune system which slows down their action. Piperine is also theorized to slow the progress and development of gout by blocking the formation of uric acid crystals from forming.
A 2008 study indicates that Piperine may also have some anti-cancer properties. The study showed that this supplement was able to inhibit the growth of colon cancer cells that were grown in a lab. Of course, more research would be needed to test and prove this hypothesis. There is also some evidence to suggest that Piperine may have a bit of anti-depressant activity as well.
One study indicated that it was able to increase the levels and activity of the neurotransmitters Serotonin and Dopamine within the brain. These powerful brain chemicals are very often deficient in people with depression and thought to help increase general feelings of well-being. It may also mean that the supplement has some ability to enhance cognitive function due to the release of these neurotransmitters.
Dopamine in particular plays a role in executive function which is related to your ability to pay attention and focus on one task at a time. Higher levels of dopamine can result in increased motivation and potentially greater productivity results.
Piperine Dosage:
It should be noted Piperine it is a very potent supplement. Many experts beliebe that at any dosage above about 15 mg per day, it might begin to affect the absorption and metabolism of a wide range of drugs and supplements.
Therefore, be very careful about using this in combination with other supplements, drugs, and medications. Begin very low, at a dose of about 5 to 10 mg per day.
Only increase once you become familiar with the effects and benefits of this supplement. Ideally, check with a doctor before adding this one to your program.
Piperine Side Effects:
This supplement is generally considered to be safe, but there do seem to be a number of unanswered questions regarding the effects of Piperine. For example, it may possibly increase the effects of medications and drugs which are already in use. Do not take this at the same time as any prescription medications, certainly not until getting it cleared by a doctor or qualified medical professional.
Piperine is a supplement which essentially amplifies the effects of many other drugs, supplements and cognitive enhancers. When paired with other nootropics, you may find that the positive benefits are more profound. However, this can also lead to the possibility of more significant negative side effects. Piperine is particularly known to enhance the absorption of supplements like Vitamin C and CoQ10.
Should you decide to add it to your nootropic stack, it would be prudent to combine it with one nootropic at a time to determine how it changes the effects of this supplement. This way you can track how Piperine influences each compound you are using in turn.
Article last updated on: June 20th, 2018 by Nootriment