Piracetam is very likely to be the first Racetam or Nootropic in general that most people try, due to the fact that it is often considered the safest and most well-tolerated.
Of course, there comes a time when many Piracetam users ask themselves the question of whether they should be taking anything else to increase their brainpower even further.
Using Piracetam in a nootropic stack can complement your results and lead to even more benefits. At this point, the next logical step is to consider a basic Piracetam stack by adding a Choline source with high bio-availability.
Alpha GPC is an excellent source for this, as it is highly bio-available. But what exactly will this nutrient do to help complement the Piracetam? Additionally, are there any side effects and what doses should be taken of your Piracetam Alpha GPC stack?



- Promotes neuron health & synaptic plasticity
- Supports memory recall & learning
- Boosts focus, visual perception & attention
Piracetam Effects
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As a review, Piracetam is the oldest and most studied Nootropic. It has been seen in research studies to have a number of benefits primarily aimed at improving cognitive function.
Users report that one of the first benefits they often experience is an increase in sensory perception, especially in the areas of enhanced sound quality and vision acuity.
After a few days or weeks of use, Piracetam may effect the memory and learning processes. Many users see their ability to remember improve, sometimes even accompanied by faster recall.
Learning capacity is also reported to be enhanced. This can be especially helpful for students as well as professionals in demanding environments.
Mental energy is also typically enhanced. Piracetam is commonly reported as increasing attention span, focus, and concentration. Often these particular effects also lead to an increase in motivation. Some research has suggested that Piracetam may even help to lower levels of anxiety, stress, and nervousness (and possibly also help to alleviate some forms of mild depression).
Alpha GPC Effects
The primary active ingredient in Alpha GPC is Choline, which is a water soluble vitamin-like nutrient that plays a role in a number of brain and bodily functions and processes. Choline is actually a precursor to the powerful neurotransmitter Acetylcholine.
While choline can be found in food sources, the vast majority of people do not get enough from their diet alone. It is estimated that as much as 90% of people are deficient in Choline, making supplementation a simple solution.
This supplement is believed to help increase the levels of Acetylcholine within the brain by providing more of the precursor materials needed. Higher levels of Acetylchoine can make all of your cognitive functions much faster and more responsive.
Neuroscientifically, it it believed that taking an Acetylcholine boosting supplement means your brain is able to make connections faster and neurons can work together with much greater ease.



- Choline source to support memory function
- Increases attention, focus & energy
- Neuroprotective for brain cell health
Piracetam Alpha GPC Synergistic Effects
Taking both Piracetam and Alpha GPC together in a stack is a smart idea due to one simple word: synergy. Both of these compounds, on their own, tend to be rather subtle with mildly noticeable effects and benefits. On the other hand, when combined and taken together they both become more effective. In essence they help to potentiate each other.
Think of Piracetam like a spark of a fire and Alpha GPC like the oxygen that keeps it burning: If you do not have enough oxygen the fire will eventually burn out. But when you add this key ingredient, the fire can burn even stronger and for a longer period of time.
The Piracetam Alpha GPC Stack has long been considered one of the best basic stacks for Nootropics users. As a direct precursor to Acetylcholine, Alpha GPC ensures that there is enough of this key neurotransmitter to keep up with the increased demand that Piracetam creates.
Alpha GPC will ensure that your body has an adequate supply of Choline. This leads to the efficient conversion and production of Acetylcholine within the brain. That means that when Piracetam comes along and binds to the Acetylcholine receptor sites, its effects are even more powerful. As a result, Acetylcholine ends up staying in the system longer and becomes even more excitatory.

- Promotes neuron health & synaptic plasticity
- Supports memory recall & learning
- Boosts focus, visual perception & attention
Proper Stack Dosages and Ratios
Taking such a stack in the most effective manner means some careful planning. You want to make sure to take enough of both items, and then to also use the proper ratio of one to the other.
Starting with Piracetam, based on research and user reviews, the most commonly taken dosage is between 1.6 to 4.8 grams, three times daily. The multiple administrations are important in order to combat the fact that Piracetam has a very short 2 or three hour half-life.
As for the Alpha GPC, most users typically take between 500 mg and 1 gram per day, depending on Piracetam dose schedule. It is best to aim for a ratio of between 4:1 and 8:1 in favor of Piracetam.
So, a dosage of 4.8 grams of Piracetam, means taking 1.2 grams of Alpha GPC (when using a 4:1 ratio) or 600 mg (when using an 8:1 ratio). Always start at the lower end of the Piracetam Alpha GPC dosage range and then adjust upward once you feel comfortable doing so.
Where To Buy Piracetam & Alpha GPC
Choline is a readily available supplement that can be found at many pharmacies and health food stores. Alpha GPC is a high quality source of choline that is slightly more specialized, however it is still typically available at specialty vitamin stores. It is also very easy to find online from many different large vendors including Amazon, as well as more specialized supplement specific online stores.
On the other hand, Piracetam is becoming more and more difficult to find within the USA due to FDA laws regarding how this compound can be marketed and labeled. Piracetam does not meet the qualifications of a dietary supplement in the US, and cannot be labeled or sold as such.
Additionally, while Piracetam has been available for years in other countries around the world as either an over-the-counter or a prescription drug, in the USA the FDA has not approved Piracetam as a drug to prevent or treat any conditions. Piracetam is an unregulated, unscheduled compound, that is now considered an investigational new drug (IND).
It is legal to buy and own Piracetam for personal use, however due to its unregulated, unscheduled status, buying Piracetam within the US can be difficult due to FDA laws surrounding the sales, distribution, and labeling of compounds like Piracetam. As such, you will not find it available at the local corner drugstore or even the specialty vitamin stores.
There are some specialized online nootropic stores based in the US that still carry Piracetam powder, however they are limited. Many people will import from countries where the sale of Piracetam is legal. There are often no issues importing when the amount is considered “for personal use,” typically a three month or less supply.
Overall, the best place to find both of these compounds is online. Just make sure to do your research and always buy from a trusted source. Peak Nootropics has consistently high customer ratings for satisfaction, service, and quality of Piracetam and Alpha GPC powders.

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- Grau M, Montero JL, Balasch J. Effect of Piracetam on electrocorticogram and local cerebral glucose utilization in the rat. Gen Pharmacol. 1987;18(2):205-11.
- Evers S, Grotemeyer KH. Piracetam and platelets--a review of laboratory and clinical data. Pharmacopsychiatry. 1999 Mar;32 Suppl 1:44-8.
- Abuzzahab FS Sr, et al . A double blind investigation of piracetam (Nootropil) vs placebo in geriatric memory. Pharmakopsychiatr Neuropsychopharmakol. 1977 Mar;10(2):49-56.
- Stockmans F, et al . Inhibitory effect of piracetam on platelet-rich thrombus formation in an animal model. Thromb Haemost. 1998 Jan;79(1):222-7.
- Pepeu G, et al . The relationship between the behavioral effects of cognition-enhancing drugs and brain acetylcholine. Nootropic drugs and brain acetylcholine. Pharmacopsychiatry. 1989 Oct;22 Suppl 2:116-9.
- Wheble PC, Sena ES, Macleod MR. A Systematic Review and Meta-Analysis of the Efficacy of Piracetam and Piracetam-Like Compounds in Experimental Stroke. Cerebrovasc Dis. 2008;25(1-2):5-11. Epub 2007 Nov 22.
- Giurgea C. The "nootropic" approach to the pharmacology of the integrative activity of the brain. Cond Reflex. 1973 Apr-Jun;8(2):108-15.
- Pepeu G, Spignoli G. Nootropic drugs and brain cholinergic mechanisms. Prog Neuropsychopharmacol Biol Psychiatry. 1989;13 Suppl:S77-88.
- Cattaneo L, Bondiolotti GP, Muller EE, Cocchi D. Effect of acute and short-term administration of cholinomimetic drugs on corticosterone secretion in the rat. Eur J Pharmacol. 1993
- Ricci A, Bronzetti E, Vega JA, Amenta F. Oral choline alfoscerate counteracts age-dependent loss of mossy fibres in the rat hippocampus. Mech Ageing Dev. 1992
- Di Perri R, Coppola G, Ambrosio LA, Grasso A, Puca FM, Rizzo M. A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res. 1991
- Sapronov NS, Nezhinskaya GI, Vladykin AL. Effects of cholinergic agonists and antagonists under conditions of spleen denervation in rats with endotoxic shock. Bull Exp Biol Med. 2010
- T?kés T, Tuboly E, Varga G, Major L, Ghyczy M, Kaszaki J, Boros M. Protective effects of L-alpha-glycerylphosphorylcholine on ischaemia-reperfusion-induced inflammatory reactions. Eur J Nutr. 2015
- Schettini G, Ventra C, Florio T, Grimaldi M, Meucci O, Scorziello A, Postiglione A, Marino A. Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats. Pharmacol Biochem Behav. 1992
Article last updated on: March 13th, 2018 by Nootriment