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Pramiracetam and Aniracetam are two of the most popular Piracetam derivatives in the Racetam Nootropic family.
These compounds are known for being more effective than Piracetam and part of the reason for that has to do with their bio-availability.
Unlike other water soluble compounds, Aniracetam and Pramiracetam are both fat soluble supplements meaning they work a little bit differently when they are absorbed by the body. This also means you have to take them in a slightly different way to get the best benefits.
Here is a look at how to use Pramiracetam and Aniracetam fat soluble nootropics in order to get the best effects.
Focus
Motivation
Reasoning- Improves focus, productivity & motivation
- Supports cognition & memory
- Heightens alertness & mental acuity
Aniracetam Fat Soluble Powder
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- What is Pramiracetam?
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Aniracetam was initially discovered by the Swiss pharmaceutical company Roche as a fat soluble analog to Piracetam.
Because it is fat soluble, it has significantly better penetration of the blood-brain barrier that all nootropics must cross in order to enhance cognition.
Aniracetam is generally considered to be five to ten times more potent than Piracetam at the same dose.
Fat solubility also means that this nootropic is metabolized much faster so the effects are felt more immediately at a greater concentration but they also last for shorter periods of time.
Whereas Piracetam can take approximately 45 minutes to start being effective, you will notice Aniracetam effects within 20 minutes of consumption. The half-life of Aniracetam is between 100 to 125 minutes. That is why it is more common to use this compound for short bursts of intensive work.
In other comparisons of Aniracetam vs. Piracetam it was discovered that Aniracetam is a better stimulating of AMPA receptors that cause Glutamate uptake. This makes Aniracetam both a member of both the racetam and Ampakine types of nootropic supplements.
Effects of Aniracetam include improved memory, higher energy levels, significantly better concentration as well as mood enhancement and lower stress levels. A lot of people will actually use Aniracetam to treat social anxiety because it can also improve verbal processing making it easier for you to communicate with others.
Motivation
Memory
Mood- Heightens focus & motivation
- Supports memory formation & recall
- Shown to enhance mood & reduce anxiety
Pramiracetam Fat Soluble Powder
Pramiracetam is an even more powerful analog of Piracetam often cited as being 30 times stronger than this original nootropic. It’s mechanism of action is very similar to aniracetam but at a much higher potency level.
One of the most unique benefits of Pramiracetam touted in user reviews and experience logs is that it increases goal-oriented behavior. It does this by increasing motivation levels and greatly enhancing concentration and focus together.
Pramiracetam also shows the same benefits for cognition, synaptic plasticity, perception and memory as the other racetams. Like Aniracetam, it is also fat soluble and its effects are felt with the same degree of immediacy.
However, Pramiracetam effects are felt for longer periods of time which is why a lot of people consider this to be the best nootropic. The half-life of Pramiracetam is approximately 4.5 to 6.5 hours so taking it every 6 hours is a good way to ensure you continue to experience the benefits throughout the day.
- Focus longer, clear brain fog & feel more motivated
- Boost energy, alertnes & memory
- Contains 12 safe and natural nootropic ingredients
Fat Soluble vs. Water Soluble
What exactly does it mean when we say that Aniracetam and Pramiracetam are fat soluble?
The most noticeable manifestation of this will be seen if you try to mix these racetam powders in water.
Instead of forming a solution (like Piracetam and Oxiracetam), your Pramiracetam or Aniracetam powder will simply clump up at the top of the glass. This can lead to some difficulties when taking these powders with water soluble nootropics in a stack. Instead, you will need to mix your Aniracetam or Pramiracetam dosage with milk in order for it to dissolve properly.
Beyond how you take your racetam dosage, there are several important things to remember about using these two supplements. Most other nootropics work best when taken on an empty stomach.
Pramiracetam and Aniracetam are the exact opposite: they need to be taken along with fatty acids in order to be absorbed properly. If you take these compounds on an empty stomach, they are less likely to enter your blood stream and may pass right through you.
You can use an essential fatty acid supplement like 2-3 g of fish oil to stack with your fat soluble nootropic so that it absorbs more readily. Or in a pinch just mix your Aniracetam and Pramiracetam powder into a glass of olive oil and drink it. The best foods to eat while taking these supplements include egg yolks, salmon, high fat yogurt and milk, almond or other high fat nuts and avocado.
While fat soluble nootropics may require you to take some additional steps to use them properly, they are much more concentrated and can do a better job of boosting your brain power.
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- Saletu B, Grünberger J. The hypoxia model in human psychopharmacology: neurophysiological and psychometric studies with aniracetam i.v. Hum Neurobiol. 1984
- Li Y, Wang JJ, Cai JX. Aniracetam restores the effects of amyloid-beta protein or ageing on membrane fluidity and intracellular calcium concentration in mice synaptosomes. J Neural Transm. 2007
- Senin U, Abate G, Fieschi C, Gori G, Guala A, Marini G, Villardita C, Parnetti L. Aniracetam (Ro 13-5057) in the treatment of senile dementia of Alzheimer type (SDAT): results of a placebo controlled multicentre clinical study. Eur Neuropsychopharmacol. 1991
- Tanaka Y, Kurasawa M, Nakamura K. Cholinergic and dopaminergic mechanisms involved in the recovery of circadian anticipation by aniracetam in aged rats. Pharmacol Biochem Behav. 2002
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- Vincent G, Verderese A, Gamzu E. The effects of aniracetam (Ro 13-5057) on the enhancement and protection of memory. Ann N Y Acad Sci. 1985
- Bartolini L, Casamenti F, Pepeu G. Aniracetam restores object recognition impaired by age, scopolamine, and nucleus basalis lesions. Pharmacol Biochem Behav. 1996
- Foltyn P, Lücker PW, Schnitker J, Wetzelsberger N. [A test model for cerebrally-active drugs as demonstrated by the example of the new substance aniracetam]. Arzneimittelforschung. 1983
- Tang CM, Shi QY, Katchman A, Lynch G. Modulation of the time course of fast EPSCs and glutamate channel kinetics by aniracetam. Science. 1991
- Mondadori C, Ducret T, Petschke F. Blockade of the nootropic action of piracetam-like nootropics by adrenalectomy: an effect of dosage? Behav Brain Res. 1989
- Zhiliuk VI, Levykh AÉ, Mamchur VI. [Platelet hyperreactivity and antiaggregatory properties of nootropic drugs under conditions of alloxan-induced diabetes in rats]. Eksp Klin Farmakol. 2012
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Article last updated on: March 13th, 2018 by Nootriment
6 Comments
I’m lactose intolerant, what can I mix with besides milk? Will almond milk work?
Hi Cassandra,
I’m not very familiar with almond milk, but my best guess would be that it should work If you try it, please let me know whether the powder is soluble or not.
I was under the impression that WATER-soluble molecules were more rapidly absorbed, and metabolized by the body. Fat soluble molecules can be stored in fat, and move about slower, with LONGER half-lives, but longer onsets as well. So, oxiracetam, being water soluble, should peak faster and be metabolized faster than fat soluble aniracetam. Any other source I look for suggests this same thing, that fat solubility means SLOWER onset and metabolism.
Could someone clarify this?
Hi Benjamin,
It’s not quite as simple as this because the individual molecules matter more than whether they are fat soluble or water soluble. In other words, some fat soluble molecules will reach peak plasma levels faster than some water soluble molecules. Aniracetam and Oxiracetam are one such case. In healthy adults given oral doses, peak plasma concentrations are reached from Aniracetam after 0.4 hours and with Oxiracetam it is closer to 1-2 hours after administration.
Or in a pinch just mix your Aniracetam and Pramiracetam powder into a glass of olive oil and drink it.
That might be a little overkill
Not at all, Olive oil is part of my bodybuilding meal plan. I take it with two meals to get my healthy fats. Pour yourself a little shot, and just take it down with a sip of water. Enjoy!