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Pramiracetam has emerged as one of the highest rated nootropics in recent years, noted for intensely boosting focus while also improving information retention, recall and processing.
Pramiracetam is observed to work by positively modulating the activity of the acetylcholine neurotransmitter.
A single dose of this compound has been shown to increase choline uptake in the cerebral cortex as well as in the hippocampus where memories are formed. For this reason, the benefits of this supplement are disproportionately greater when it is used in a Pramiracetam Choline Stack.
Stacking a favorite racetam with a quality source of Choline is a common practice among experienced nootropic users. Taking Pramiracetam with an acetylcholine precursor helps to increase the effectiveness of this smart drug and, for some people, it prevents the occurrence of a common side effect.
Not only can Choline mitigate headache which is one of the most commonly reported side effects of Pramiracetam use, it can also provide beneficial cognitive boosts on its own for those who may be deficient in this essential nutrient.
The ratio of Choline to Pramiracetam is important with this combination of nootropics. Using the wrong ratio can exacerbate side effects or cause the user to have no beneficial experience at all.
Focus
Motivation
Reasoning- Improves focus, productivity & motivation
- Supports cognition & memory
- Heightens alertness & mental acuity
Pramiracetam
Related Topics
- What is Pramiracetam?
- User Review
- Benefits and How it Works
- Dosing Information
- Side Effects
- Experience Reports
- Purchasing Pramiracetam
- Legal Status
- Using Bulk Powder
- How to Take Capsules
- Pramiracetam Stacks
- Stack with Choline
- Comparison to Piracetam
- Comparison to Noopept
- Comparison to Oxiracetan
- Comparison to Aniracetam
Pramiracetam is estimated to be about 30 times more potent than Piracetam, its parent drug.
This means the dose needed to achieve the desired effect is much smaller than that of Piracetam.
Like other Racetams, it is generally considered non-toxic and safe for long-term use. Taking more than the recommended dosage doesn’t seem to improve the effect and is not recommended.
Pramiracetam improves mental abilities such as memory, focus and mental alertness. Some users report improved mood with this nootropic, but its primary mechanism of action does not involve interplay with dopamine or serotonin receptors. Many users say it has an emotion-blunting effect similar to the ADHD drug Ritalin.
Focus comes easily and the user’s spatial memory often is enhanced. For students studying dense texts, Pramiracetam will enhance the ability to absorb and recall data more easily and with greater speed.
Choline
Choline is the precursor to an important neurotransmitter called Acetylcholine. This neurotransmitter is involved in memory formation, consolidation and recall. Higher levels of acetylcholine are known to inhibit distractions, making it easier to focus fully on one task at a time.
It had been thought that most humans are able to provide the necessary amounts of this essential nutrient through the foods they eat, however, a surprising number of people are actually Choline deficient. Foods which contain high amounts of Choline include eggs, sunflower seeds, liver, tofu, broccoli and brewer’s yeast.
Acetylcholine levels also naturally start to decline between the ages of 20 – 30 and this is often pointed to as one of the major harbingers of Alzheimer’s disease. Some of the signs of Choline deficiency can be quite mild but noticeable.
For example, brain fog, headaches, fatigue and insomnia. Studies of pregnant women have shown large amounts of Choline are used to develop the fetal nervous system and women who are deficient in Choline have a higher incidence of neural tube defects.
Memory
Brain Health Cognition- Supports memory and synaptic plasticity
- Raises acetylcholine levels
- Promotes brain health and focus
Benefits of Choline for the Brain
Taken as a nutritional supplement, Choline can provide the brain with some of the fuel it needs to function clearly and optimally. Especially when using another nootropic like Pramiracetam, the brain needs more acetylcholine in order to satisfy the heightened rate of mental activity and neuronal communication.
There are several forms of Choline available, though they are not all equal in efficacy because of their bio-availability. Two forms which are recommended are Alpha-GPC and Citicoline, both of which are able to cross the blood-brain barrier in larger quantity, allowing them to make themselves available for conversion to acetylcholine.
Stacking Ratio or Dosage
Pramiracetam seems especially sensitive to the ratio dosage of Choline when the two are stacked together. Many racetam users will supplement with Choline if they experience “racetam headaches” which are thought to be due to increased acetylcholine activity.
Most people report the headaches go away once Choline is added to the mix. Due to the potency of Pramiracetam, most users will supplement with Alpha-GPC or Citicoline in order to offer their brains the Choline it needs.
We recommend starting with a 2:1 ratio of Pramiracetam to Citicoline:
- 200mg Pramiracetam
- 100mg Citicoline
Pramiracetam is a fat soluble supplement and should therefore be consumed with a fat source in order to ensure that it is sufficiently absorbed from your intestines into your blood stream. You may way to mix this nootropic powder into a glass of milk or make sure that you are taking it after a meal with some fat content.
- Focus longer, clear brain fog & feel more motivated
- Boost energy, alertnes & memory
- Contains 12 safe and natural nootropic ingredients
You should keep in mind that racetams take time before you experience the full effect, though Pramiracetam seems to offer the user a noticeable affect fairly early in comparison to the others.
Once you have taken this stack for a few days, you can adjust your ratio if needed by increasing your Pramiracetam to 250mg and your Citicoline to 125mg. Adjustments should be made slowly, over time, and shouldn’t be rushed.
Pramiracetam dosage should not exceed 400mg at the outside. Pramiracetam is a potent nootropic and more serious side effects are possible at the higher levels.
Stacking Pramiracetam and Choline should offer you a synergistic enhancement of memory, focus, concentration, learning ability and improved technical thinking ability. Users have also reported an enhanced sense of perception of both music and colors as well as heightened awareness and alertness in general.
Tweaking your ratio slowly to gain the optimal cognitive experience may take a little time, but once you are able to find your sweet spot, it is usually well worth the effort.
Pramiracetam Centrophenoxine Stack
A closely related stack is the Pramiracetam Centrophenoxine Stack. Centrophenoxine is a more bioavailable form of DMAE bound to Parachlorphenoxyacetic acid (pCPA) to enhance its ability to penetrate the blood-brain barrier.
DMAE is similar to choline in its chemical structure, but has one fewer methyl group. It can be converted into choline in the body. Some people do stack DMAE with Pramiracetam for its cognitive benefits, but Centrophenoxine is a stronger alternative to achieve nootropic effects.
This smart drug has been used under the brain name Lucidril to treat Alzheimer’s disease, age-related memory loss and dementia since 1959. In addition to increasing the availability of Choline in the brain, Centrophenoxine has been shown to promote the following benefits:
- Stimulate the release of acetylcholine in the brain
- Increase blood flow, oxygenation and glucose utilization in brain cells
- Exhibits antioxidant benefits and neuroprotective properties
- Reduces lipofuscin deposits (pigmented lipid residues) that build up in neurons and can impair cognitive functioning
- Promotes RNA synthesis and Protein Synthesis
- Exhibits anti-aging and pro-longevity effects in animal studies
If you are using Centrophenoxine instead of one of the choline supplements mentioned above, it should be taken in a dosage of 250 mg with Pramiracetam powder. Centrophenoxine is generally well tolerated but in some people causes a worsening of headaches, mood problems and gastrointestinal side effects.
Summary
Starting with a balanced ratio of 2:1 and titrating if needed can provide the user with a highly focused and enhanced cognitive state. The ideal Pramiracetam Choline stack ratio will most often be based on the individual neurochemistry of the user. These two nootropics intensify the benefits of each other, working to increase intelligence, mental fluidity and clarity of thought in a profound manner.
While the mechanism of action for Pramiracetam is not considered to involve Central Nervous System stimulation, most users report increased energy and motivation when taking this stack. You may find it particularly effective for extended periods of mentally draining work such as studying, reading or performing any type of critical analysis.
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Article last updated on: March 13th, 2018 by Nootriment
1 Comment
Hello!
I see in the above article that the stacked dose of Pramiracetam with a choline is 2:1. How many times a day should this ration be taken?