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Pramiracetam powder is generally agreed to be the strongest member of the widely available Racetam class of Nootropics.
Many people will upgrade to Pramiracetam powder after having used the weaker Racetams to start with.
But if you have experience with Piracetam, Aniracetam or Oxiracetam then it is important to understand what the right Pramiracetam dosage is or you might end up taking too much.
Because Pramiracetam is so much more concentrated than Piracetam (some people say it is 30 times more potent than this popular nootropic), you will need a much smaller Pramiracetam dose to get the same effects.
In this article we will go over some of the most important considerations to keep in mind when using Pramiracetam powder, including the proper dosing.
The idea of taking a pill or powder supplement to improve cognitive abilities like learning and memory is something that people have dreamed about for years. Today, this is indeed possible.
Not only does a supplement such as Pramiracetam offer these possible benefits, but it also offers extremely low toxicity and very few side effects.
Exactly how does this supplement work, what are the potential benefits, and are there any dangerous side effects to know about?
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Reasoning- Improves focus, productivity & motivation
- Supports cognition & memory
- Heightens alertness & mental acuity
What is Pramiracetam?
Related Topics
- What is Pramiracetam?
- User Review
- Benefits and How it Works
- Dosing Information
- Side Effects
- Experience Reports
- Purchasing Pramiracetam
- Legal Status
- Using Bulk Powder
- How to Take Capsules
- Pramiracetam Stacks
- Stack with Choline
- Comparison to Piracetam
- Comparison to Noopept
- Comparison to Oxiracetan
- Comparison to Aniracetam
This supplement is a fat soluble member of the Racetam family that was initially developed in Belgium during the 1970’s.
It is actually derived from the original Racetam, but has an increased potency (it is up to thirty times as strong as Piracetam).
Pramiracetam has become a very popular Nootropic supplement and is used in many different countries.
In some cases it is even prescribed for medical use, although it is more commonly taken with the expectation of helping to improve memory and cognition.
How Does Pramiracetam Work?
Pramiracetam works in a fashion that is similar to most other Nootropics. It is very effective at enhancing brain metabolism by stimulating oxidative catabolism and increasing energy levels by improving ATP turnover and cAMP levels within the brain.
Other interesting methods of action include increasing phospholipid metabolism and protein biosynthesis.
Pramiracetam also works by modulating and influencing a number of diverse receptor sites within the brain. This includes the glutamate (Cholinergic) and the Acetylcholine receptor sites.
Although these mechanisms of actions are not fully understood, it is thought that the supplement helps to improve the reuptake and efficiency of these channels.
- Improves focus, productivity and motivation
- Boosts cognition and memory performance
- Heightens alertness and reasoning
One of the methods of action that is most effective with this supplement is to influence choline uptake into the hippocampus area of the brain.
This also leads to specific improvements in the amount of Acetylcholine uptake and channel specific nerve impulses in this area of the brain.
There has also been a lot of research regarding the apparent ability of Pramiracetam dosages to improve and increase communication across the corpus callosum, which is the bundle of nerves separate the two hemispheres of the brain. There is much excitement about this being a possible method to help enhance the development of new ideas and even thought processes.
This specific method of action within the hippocampus may also be responsible for something known as Acetylcholine receptor burn out. If this occurs, it may result in fatigue and/or headaches. Of course, this can usually be remedied by adding a little bit of extra choline supplementation to your regimen.
Pramiracetam Benefits:
Despite many Nootropics have some beneficial effects on symptoms of anxiety or mood, Pramiracetam appears to only relate to cognitive functions. This is likely because this supplement does not modulate or effect levels of chemicals like dopamine, serotonin, and GABA within the brain).
Of course, the major benefit imparted is overall improved cognition. Many users report having higher levels of sensory perceptions while taking Pramiracetam doses. There is also the benefit of improved working and long term memory, an increased ability to learn, and easier advanced logical and technical thinking ability.
Combined with an improved ability to focus and concentrate makes this an incredible cognitive supplement.
Researchers feel that most of these benefits can be explained by the specific effects the supplement seems to have on the Acetylcholine receptors. It seems like this is more of a “true” smart drug, with very few unrelated effects. Many users have described this as unlocking areas of thinking and mental performance abilities that were hereto not realized.
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Pramiracetam Safety & Side Effects:
Despite this supplement being much more potent than some of the ‘milder’ Nootropics it is generally regarded as safe.
There have been very limited Pramiracetam side effects reported and no serious overdoses on record.
Supplement manufacturers have also investigated possible safety issues in depth and also regard this as safe.
When the few known side effects are reported, they are usually only seen in users that take well above the recommended dosage.
These can include headaches (most common with all forms of Racetam Nootropics), fatigue, insomnia, nervousness, and/or GI discomfort. In most cases, simply reduce the dosage will stop these from reoccurring.
Recommended Pramiracetam Dosage:
The recommended Pramiracetam dosage for this product is between 200 and 400 mg per daily. This can be taken all at once, or split into equally divided administrations throughout the day.
Do not exceed these recommendations unless under doctors orders. Some people have experimented with Pramiracetam mega doses in excess of 1 gram without serious negative side effects, but we strongly discourage this practice as you may have a bad reaction.
It is best to begin by testing your sensitivity. This involves starting off with a very low dose, perhaps 50 mg or so. Then only increase (and only go up to the recommended dosage) little by little.
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- Gower AJ, Tricklebank MD. The effects of cholinergic drugs support an avoidance learning hypothesis of brief footshock-induced analgesia. Neuropharmacology. 1986
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- Maresová D, Mares P. The action of pramiracetam on consequences of hypobaric hypoxia is only moderate. Physiol Res. 1996
- Shih YH, Pugsley TA. The effects of various cognition-enhancing drugs on in vitro rat hippocampal synaptosomal sodium dependent high affinity choline uptake. Life Sci. 1985
- Fang Z, Liu X, Xiao Y, Jiang W. [Pharmacokinetics of pramiracetam in animals]. Hua Xi Yi Ke Da Xue Xue Bao. 1999
- Poschel BP, Ho PM, Ninteman FW, Callahan MJ. Pharmacologic therapeutic window of pramiracetam demonstrated in behavior, EEG, and single neuron firing rates. Experientia. 1985
Article last updated on: March 13th, 2018 by Nootriment
2 Comments
y se puede usar diario o causa tolerancia?
Bought in powder form how do l measure 400 mg
Thanks