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Pramistar is a brand name for the nootropic drug Pramiracetam, manufactured by Berlin-Chemie AG, part of the Italian Menarini Group.
Pramistar is marketed as a nootropic remedy, prescribed to adults with memory disorders, psychoorganic syndrome, treatment-resistant depression or emotional lability.
This drug has also been used clinically in some countries to treat brain injuries and cognitive disorders like Alzheimer’s disease, Parkinson’s disease and senile dementia.
Each pill contains 600 mg of the active ingredient Pramiracetam, which is believed to enhance motivation, cognitive function, memory and learning.
Pramistar is cited as 15-30 times stronger than Piracetam, the original racetam nootropic from which it is derived.
Pramistar is purported to boost short-term memory, vasodilation, and to affect neuropeptide mediation. It may work by increasing cholinergic activity in the hippocampus.
In this article, we will review the research behind Pramistar’s effects, how it is used, safety information and enefits of Pramistar and where to buy Piracetam online.
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Pramistar
Related Topics
- What is Pramiracetam?
- User Review
- Benefits and How it Works
- Dosing Information
- Side Effects
- Experience Reports
- Purchasing Pramiracetam
- Legal Status
- Using Bulk Powder
- How to Take Capsules
- Pramiracetam Stacks
- Stack with Choline
- Comparison to Piracetam
- Comparison to Noopept
- Comparison to Oxiracetan
- Comparison to Aniracetam
According to the patient leaflet distributed with this drug, Pramistar is used in the treatment of concentration and memory disorders.
It has been used to treat symptoms linked to degeneration of nerve cells or pathologies affecting blood vessels in the brain. These symptoms can present in elderly patients on in people suffering from traumatic brain injury.
The active ingredient in this medication is Pramiracetam, which is believed to improve memory and learning capacity. This substance is also taken off-label as a nootropic supplement by people who want to enhance their cognitive function.
Pramiracetam is a fat-soluble derivative of Piracetam, which is the parent compound of the racetam family of nootropics. Where Piracetam has an amide group in its chemicals structure, Pramiracetam has a dipropan-2-ylaminoethyl group.
As a result of this change, it has greater bioavailability and better transportation across the blood-brain barrier compared to Piracetam. This means that smaller dosages are required to produce effects.
Anecdotally, Pramistar is said to promote intense focus and motivation, making it easier to complete long and arduous tasks without distraction. User reviews say that it boosts mental clarity, improves energy levels and promotes a positive mood.
Not everyone experiences benefits from taking this nootropic drug. Some describe side effects such as emotional blunting, fatigue, irritability and lack of empathy for others.
There is limited research available into the effects of Pramistar on humans. While some clinical studies do exist, the sample sizes used tend to be small. More studies are needed to evaluate efficacy of this drug for treating neurological conditions.
Furthermore, most of the research available has examined the effects in patients diagnosed with some form of cognitive dysfunction. It is not clear whether this drug can improve brain function in healthy, normal adults.
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Pramistar Effects
Pramistar’s primary mechanism of action is to increase HACU, which stands for high affinity choline uptake.
Choline is the primary building block in the production of acetylcholine – a neurotransmitter that is involved in excitatory signaling between neurons and that plays a role in learning, memory, reasoning and attentional control.
By increasing the uptake of choline into neurons, Pramistar can increase actylcholine synthesis in the brain. It has been shown to increase cholinergic activity and increase acetylcholine turnover at nerve terminals in the hippocampus.
The hippocampus is part of the brain involved in long-term memory formation, memory consolidation and encoding. Research in rats shows that this drug can improve long-term memory performance on a radial arm task.
Research also shows that this drug can increase nitric oxide synthase (NOS) levels in the rat cortex. Nitric oxide synthase is the enzyme that synthesizes nitric oxide, which acts as a vasodilator (dilating blood vessels in the brain).
It may contribute to increased bloodflow, glucose uptake and oxygen delivery to brain tissue, which can have a positive impact on neuron cell health as well as energy metabolism.
Trials involving rats demonstrate that some of Pramistar’s effects are mediated by the adrenal glands, which are endocrine glands that produce hormones including adrenaline, aldosterone and cortisol. This may explain why many users report higher levels of alertness, wakefulness and focus when taking Pramistar.
Other studies have found that Pramiracetam affects EEG function in elderly rats, restoring brain wave profiles to those seen in younger animals. More research is needed to understand this effect.
Directions for Use
If you have been prescribed Pramistar 600mg tablets by a doctor, take this drug according to the directions provided by your physician.
The manufacturer’s patient leaflet recommends a dosage of one tablet every 12 hours, not to exceed 2 tablets per day. This provides a dosage range of between 600 – 1200 mg per day.
As a smart drug or cognitive enhancer, many users will take lower pramiracetam dosages between 200 – 600 mg per day.
Researchers have shown that there is a therapeutic window in the dosages for this compound that produce beneficial effects. Dosages that are too high or too low will not produce effects.
According to the manufacturer, a clinically significant effect will only be observable after 5-8 weeks of treatment with this nootropic agent.
In anecdotal user reviews, Pramiracetam is viewed as one of the fastest acting Nootropics. It also has a longer half-life of between 5-7 hours.
Pramistar is fat soluble and should be taken with food or some sort of lipid source such as milk or fish oil. This will ensure that it is properly absorbed from your gastrointestinal tract.
If using generic Pramiracetam powder, be aware that the powder has an extremely bitter taste. It is recommended to encapsulate the powder or to purchase oral pills in order to avoid this unpleasant taste.
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Side Effects & Drug Interactions
Pramistar has not been observed to cause any dangerous side effects and is normally well-tolerated in clinical trials. As with any medication, some mild or temporary side effects are possible.
Common adverse effects are defined as having a frequency of between 1-10% of users. The common negative effects of Pramistar may include dizziness, agitation, insomnia, nausea, and upper abdominal pain.
Uncommon side effects are those affecting less than 1% of all users. Uncommon side effects can include dry mouth, digestive disorders (dyspepsia), decreased appetite, muscle tremors and confusion.
Rare side effects can include depressed mood, muscle cramps, diarrhea, or enuresis (urinary incontinence). Other side effects are possible, but have not been reported in clinical trials.
One study that looked at the effects of Pramistar in Alzheimer’s patients found a small percentage of mild side effects reported including headaches, dizziness, fatigue, and loss of appetite. These latter symptoms were only seen when giving a patient 4000 mg per day orally – an amount which is 10 times higher than the currently recommended dosage.
Pramistar should not be used by individuals who have been diagnosed with a condition affecting liver function or people who have impaired kidney function.
It has not been approved for use in women who are pregnant or breast-feeding. Do not drive or operate machinery if you experience side effects of Pramistar, including dizziness, agitation, tremors or confusion.
Consult with your doctor before taking this drug if you also take medications that affect blood clotting (including aspirin, anti-coagulants or warfarin).
Pramiracetam may interact with digoxin, a drug prescribed to patients with heart conditions. It may also interact with xanthines, such as theophylline, as well as and angiotensin converting enzyme inhibitors like captopril.
Buy Pramistar Tablets
Pramistar 600 mg tablets are sold as a prescription medicine in some countries in Europe, including Latvia and Lithuania.
In Romania, this nootropic drug is sold with Pramiracetam sulfate as the active ingredient.
The same ingredient is also sold under the trade name Neupramir by Lusofarmaco and labelled as Remen by Parke-Davis, which is the company that first developed this drug.
If you live in the United States, brand name formulations of the drug are difficult to buy online and tend to be more expensive.
The more popular option today is to purchase generic Pramiracetam powder or capsules. Pramiracetam can be purchased in bulk for $59.99 per 50 grams or in 300mg oral capsules at a cost of $0.58 per dosage.
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Article last updated on: March 13th, 2018 by Nootriment