ProDentis is a probiotic supplement produced by BioGaia, designed to aid oral health and help prevent cavities and gingivitis. It is composed of Lactobacillus Reuteri ProDentis, which is a blend of two probiotic strains L. reuteri DSM 17938 and ATCC PTA 5289.
BioGaia probiotics with Lactobacillus ProDentis are recommended to treat dental conditions and to support healthy gums. This strain of probiotic is also used to help prevent bad breath and is used to treat oral thrush.
Probiotic bacteria are generally associated with digestive function and supporting a healthy immune system. These beneficial bacteria also play a role in protecting the health of the mouth and in inhibiting the development of dental cavities.
The probiotic strains that make up Lactobacillus Reuteri ProDentis help to combat the growth of harmful bacteria in the mouth, gums and teeth. These natural lactic acid bacteria also help to break down food and can contribute to overall health and wellness.



- Supports a healthy immune system & microflora
- Promotes digestion & nutrient absoprtion
- Combats pathogenic bacteria; Improves metabolism
ProDentis Probiotic Review
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- Lactobacillus Acidophilus
- Lactobacillus Bulgaricus
- Lactobacillus Rhamnosus
- Bifidobacterium Bifidum
- Bifidobacterium Infantis
- Bifidus Regularis
According to the manufacturer BioGaia, Lactobacillus ProDentis adheres to the oral mucosa and prevents the spread of pathogenic bacteria that can cause cavities, bad breath and gum decay.
This product is available in an oral supplement form, as a lozenge and in chewing gum form. Each capsule contains 200 million live Colony Forming Units (CFUs) of Lactobacillus Reuteri ProDentis bacteria.
The manufacturers state that this product has been tested in more than 20 scientific studies and has been found safe for children, adults, pregnant women and elderly individuals.
ProDentis Benefits
The mouth is populated by more than 700 bacterial species that can help to protect against bad bacteria which degrade oral health. These bacteria work to prevent the formation of plaque and other signs of gum disease.
It is important to maintain a healthy balance of good bacteria to bad bacteria in the mouth and digestive tract. If this balance is disrupted, a state of dysbiosis is created. This can lead to gum problems, cavities and tooth decay.
A number of different factors can result in the bacterial balance in the mouth being disrupted. Dietary choices, poor hygiene, stress, the environment and genetic factors can all affects the balance in the oral microflora.
Taking a probiotic supplement like BioGaia ProDentis can help to restore a health balance and increase the ratio of good to bad bacteria. This product is typically used on an on-going daily preventative basis, though some dentists may recommend it for short-term treatment of specific dental health conditions.
ProDentis Probiotic Supplements for Bad Breath
An article published in Scientific America in May 2013 estimated that 25 percent of people worldwide had chronic bad breath. Researchers determined this was caused by gas-emitting bacteria Porphyromonas gingivalis, Treponema denticola and Prevotella intermedia which thrive on the tongue and below the gum line.
Streptococcus mutans do cause acid and dissolves enamel but are not responsible for causing bad breath.
Balanced mouth flora was found to be more beneficial for controlling bad breath than daily use of alcohol-based mouthwashes that could cause the mouth to dry out and increase the bad odor-causing bacteria.
Mouthwashes that contain probiotics reduce the Streptococcus mutans population to help reduce tooth decay. Lozenges with Streptococcus salivarius K12 and Lactobacillus reuteri Prodentis help oral malodour. The European Federation of Periodontology recommends the use of probiotics for good dental health.
BioGaia ProDentis for Oral Health
A clinical study published in the Journal of Peridontal Research in December 2015 acknowledged previous studies that established probiotics created a biofilm and protect the oral tissues against the action of periodontal pathogenic bacteria.
It was found after treatment with a dosage of one Lactobacillus reuteri Prodentis tablet every 24 hours over 30 days, both the patients with mucositis and the patients without peri-implant disease showed improvements in the clinical parameters.
These parameters included crevicular fluid volume, modified plaque index, probing depth and modified gingival index (MGI). MGI is a measure of severity and location of lesions in periodontal disease
Concentrations of interleukin 1, interleukin 6 and interleukin 8 were also measured. Interleukins are a group of cytokines which are secreted proteins and signal molecules. Signal molecules control basic cellular activities and coordinates cell actions that are expressed by white blood cells (leukocytes).
In the probiotic clinical group, there were reductions in cytokine levels. These changes and improvements in the clinical parameters did not occur with the placebo group.
This clinical study concluded that taking this probiotic strain was beneficial for the treatment of peri-implant mucositis. This is defined as inflammation in the soft tissue surrounding a dental implant and with no loss of the supporting bone.
This probiotic is also useful for preventing this condition because the clinical parameters improved in healthy individuals too. Oral mucositis is an inflammation and ulceration in the mouth.
A clinical study published in the Scandinavian journal Actna Odontologica Scandinavica in May 2013 showed the probiotic Lactobacillus reuteri Prodentis improved the clinical outcomes in non-smokers with beginning to moderate chronic periodontitis.
Periodontitis is an inflammatory disease affecting the periodontium – tissues that surround and support the teeth.
BioGaia ProDentis Safety Review
BioGaia ProDentis probiotic supplements, lozenges and chewing gums are considered safe for use in children, adults, the elderly and in pregnant women. There is a low risk of side effects when used appropriately.
While safe for most health individuals, ProDentis probiotics should not be taken by those with impaired immune systems or those using a catheter. People with open surgical wounds and SBS (Short Bowel Syndrome) should also avoid probiotics.
This is some concern about the effect of the probiotic Lactobacilli on plaque lactic acid (LA). Some researchers have theorized that it may increase acidogenicity in dental plaque, but probiotic strains developed for dental conditions are not among these strains.
Lactobacillus reuteri prodentis is effective for treating gum diseases, bad breath, oral thrush and mucositis. This probiotic is also used to promote a healthy oral and gut ecology.
- Flichy-Fernández AJ, The effect of orally administered probiotic Lactobacillus reuteri-containing tablets in peri-implant mucositis: a double-blind randomized controlled trial. J Periodontal Res. 2015 Dec;50(6):775-85. doi: 10.1111/jre.12264. Epub 2015 Feb 25.
- Vicario M, Clinical changes in periodontal subjects with the probiotic Lactobacillus reuteri Prodentis: a preliminary randomized clinical trial. Acta Odontol Scand 2013 May-Jul;71(3-4):813-9. doi: 10.3109/00016357.2012.734404. Epub 2012 Nov 26.
- Szkaradkiewicz AK, Effect of oral administration involving a probiotic strain of Lactobacillus reuteri on pro-inflammatory cytokine response in patients with chronic periodontitis. Arch Immul Ther Exp (Warsz) 2014 Dec;62(6):495-500. doi: 10.1007/s00005-014-0277-y. Epub 2014 Feb 9
- Hallström H, Probiotic supplements and debridement of peri-implant mucositis: A randomized controlled trial. Acta Odontol Scand 2016 Jan;74(1):60-6. doi: 10.3109/00016357.2015.1040065. Epub 2015 May 8.
- Keller MK, Effect of chewing gums containing the probiotic bacterium Lactobacillus reuteri on oral malodour. Acta Odontol Scand 2012 May;70(3):246-50. doi: 10.3109/00016357.2011.640281. Epub 2011 Dec 20.
- Keller MK, Acid production in dental plaque after exposure to probiotic bacteria. BMC Oral Health 2012 Oct 24;12:44. doi: 10.1186/1472-6831-12-44.
Article last updated on: March 13th, 2018 by Nootriment