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Propranolol is a sympatholytic non-selective beta blocker.
This type of beta blocker is used to treat a number of different conditions including hypertension, anxiety and panic. In fact, this drug was the first successful beta blocker ever developed.
It is available in a number of different forms and sold and marketed under a number of different names like Ciplar, Inderal, Avlocardyl, Deralin, Dociton, Inderalici, and others.
This drug is also thought to be potentially effective in the treatment of a number of additional diseases and conditions. It has even been used to help improve instances of stage fright and for controlling hand tremors (especially in surgeons before they perform operations).
It was developed by British scientist James W Black during the 1960’s. He was also awarded the Nobel Prize in Medicine for this discovery (in 1988).
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Propranolol Effects:
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Propranolol is a very effective and quick acting drug. The primary mechanism of action is for the pharmaceutical is to cross over the blood-brain barrier and enter into the central nervous system.
Once there, it begins to work by binding to several neurotransmitters. What it does is to inhibit the sympathetic nervous system by blocking the action of beta receptors in the systems’ nerves.
This works to reduce the action and activity, primarily, of the neurotransmitter norepinephrine. By doing so, since this chemical influences a number of involuntary processes, Propranolol is able to reduce the heart rate and also treats abnormally rapid heart rhythms.
Another way in which this drug works is by reducing the force of contraction of the heart muscle. This is achieved through essentially the same mechanism of action described above. This also lowers the blood pressure, since there is less force pushing it through the circulatory system.
Both of these actions together reduce the need for oxygen by the heart, which can also be beneficial in treating heart pain (angina pectoris).
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Propranolol Benefits:
As an effective beta blocker the most well-known and effective use of this drug is for the treatment of various heart and circulatory issues. This includes hypertension and angina pectoris as described above.
Other conditions for which this drug may be used include tachyarrhythmias, myocardial infarction, and control of tachycardia (rapid heart beat) and tremors which are associated with anxiety, hyperthyroidism or even lithium therapy. The drug is also known as an effective treatment for migraines, cluster headaches, tension headaches, and hyperhidrosis.
Another interesting benefit of this drug is to help with controlling and even preventing stage fright.
Several musicians and other performers use Propranolol on a regular basis strictly for this purpose. It is also popular among public speakers and anyone who has to give a speech or presentation in front of a large audiences.
Indeed, even surgeons have been known to use the drug in an effort to control their own innate hand tremors during surgery.
There are also some benefits for this drug associated with the treatment and prevention of post-traumatic stress disorder. Studies have shown that someone who is given Propranolol immediately after a traumatic event show less severe symptoms of PTSD compared to control groups who did not receive the compound. It also may be helpful at reducing the incidence and effects of nightmare related cardiac activity including higher pulse rates and increased adrenaline levels.
Propranolol Dosage:
The proper dosage level for Propranolol depends upon the purpose for its use in the first place. For example, as a treatment for hypertension (high blood pressure), the suggested dose is between 80 and 240 mg up to twice a day.
If you are able to find a longer-lasting formulation, then you should only need 80-160 mg per day. Never exceed a dose of 640 mg per day. When this drug is being used for help treating chest pain, then the dose would be 80 to 320 mg (160 mg if using a long-acting formulation).
For abnormal heart rhythms, you only need 10 to 30 mg, taken 3 to 4 times per day. For preventing migraines, take between 80 and 240 mg. Also, remember that this is a powerful and fast-acting drug. Therefore, you would be wise to start out with the lowest effective dose and only increase after being sure how the drug affects you.
Propranolol Side Effects:
There are some possible drug interactions to be careful to avoid when using this drug. This includes calcium channel blockers and digoxin (Lanoxin), since they are able to lower blood pressure and heart rate to dangerous levels when taken with Propranolol. It should also be used with greet caution in patients who have been diagnosed with diabetes.
You may also experience a number of potential Propranolol side effects. These may include shortness of breath, swelling of the ankles and feet, cold feet and hands, skin problems, hallucinations, nightmares and depression. There are also a number of more general side effects that seem to be common to almost all beta blockers like weight gain, tiredness, slow heart beat, dizziness, nausea, and decreased sex drive.
Propranolol Review:
Propranolol is a powerful drug that should not be used without medical guidance. If you are experiencing high blood pressure or diminished heart function, it may be worthwhile to speak to your doctor about this drug. Some people have investigated the nootropic effects of Propranolol because it is able to reduce social anxiety particularly in situations likely to cause stage fright.
While there are limited review of successful usage of Propranolol for individuals making presentations or speeches, there are serious side effects to this drug that need to be weighed.
If you are looking for an anti-anxiety nootropic that performs better than Propranolol, consider Noopept, Phenibut, Sulbutiamine or Picamilon.
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Article last updated on: March 4th, 2018 by Nootriment
1 Comment
Mi hijo tiene temor para hablar y pienso que el propanolo le puede ser útil el se resiste a ir al psiquiatra aunque ya a tenido citas pero toma en las mañanas la mitad de clonazepan de 5mg Qué me sugiere