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Pyritinol Hydrochloride is a nootropic that often gets overlooked in favor of some of the stronger cognitive enhancers available today.
However, it offers a number of benefits both for brain health and mental functioning.
It has been extensively used as a prescription medication in European countries for the treatment of cognitive and learning disorders, especially in children.
You may see it sold under the names Encephabol, Encefabol, Pyritinol Dihydrochloride Monohydrate or as Pyridoxine disulfide. What should you know before you buy Pyritinol powder and where can you find it for sale online?
Memory
Mental Function
Mood- Increases acetylcholine activity
- Promotes reasoning, memory & learning
- Supports dopaminergic activity & mood
Pyritinol Hydrochloride
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Pyritinol was first developed by Merck Laboratories in 1961 as a semi-synthetic analog of Vitamin B6 (Pyridoxine HCL). It is composed of two Pyridoxine molecules bonded together by a disulfide bridge.
While it was initially developed to treat Vitamin B6 deficiencies due to its superior absorption rate, it became popular as a nootropic supplement used to improve brainpower and mood.
Pyritinol is one of the oldest nootropics still in use today and it has been extensively researched, particularly during the period of the 1980’s and 1990’s.
While most of this research has been published in British, French, German, Czech, and Swiss journals, it has been virtually ignored by the AMA and FDA. It is only now becoming more widely available throughout North America.
The Benefits of Pyritinol
Pyritinol Hydrochloride has a number of positive uses, but one for which it has been particularly lauded is as an anti-oxidant. It is highly effective at protecting the brain from hydroxyl radicals that can cause oxidative damage.
Hydroxyl radicals can be very harmful to red blood cells, lipids (body fats), proteins, DNA and neurons. This may be one reason why Pyritinol is recommended as a hangover remedy following alcohol intoxication.
Pyritinol is also demonstrated to enhance nerve activity in an area of the brain called the locus coeruleus. This part of the brain plays an important role in regulating stress reactions and feelings of panic, anxiety, and even depression.
This nucleus in the pons region is also responsible for the synthesis of Norepinephrine (Noradrenalin) that is used in the brain. Pyritinol may improve stress responses by increasing the secretion of norepinephrine which also has implications for improved focus, motivation, energy and mood.
This supplement also enhances the brain’s ability to transport glucose through the blood-brain barrier and into the central nervous system. The brain cannot use fat for energy and must meet its energy needs by using glucose (or sugar).
By improving the rate at which glucose is taken up by brain cells, Pyritinol Hydrochloride may lead to overall improvements in cognitive processing. Studies have found it effective at boosting concentration, decision making, impulse control, and mental energy.
A further mechanism of action that has been observed is improvements to the health and function of cholinergic neurons (or neurons that use acetylcholine as their primary neurotransmitter).
Pyritinol hydrochloride appears to aid in the recovery and repair of impaired or damaged neurons in the cholinergic system. It is able to increase the uptake of choline into brain cells leading to an increase in acetylcholine levels. This is linked to improved focus, short-term working memory and memory formation and consolidation.
Using Pyritinol powder also enhances the movement and sustainability of neutrophils, which are the most common form of white blood cells in the body. They act as the primary method of defense against infection. As they perform their intended tasks, these blood cells become damaged and self-destruct. Pyritinol helps to migrate these cells as well as prolong their self-destruction process.
Where to Buy Pyritinol
You can buy Pyritinol from a number of online sources in the United States where it is sold over-the-counter as a dietary supplement.
You do not need a prescription to purchase Pyritinol Hydrochloride powder and this nootropic is legal in most countries around the world.
Generally, formulations that are sold under the generic label of Pyritinol are far cheaper than the non-generic Encephabol tablets. You can purchase 50 grams of bulk powder from Peak Nootropics for $29.99.
Dosages for Pyritinol Hydrochloride range between 100 to 600 mg per day. The half-life of this nootropic is fairly short, so it is recommended to use it in several smaller doses throughout the day. Individuals will want to adjust the dose based on their personal sensitivity as well as their goals.
As an anti-aging or life extension supplement, it is typical to take 100 mg two to three times per day. For cognitive enhancement or memory boosting effects, one might want to take 200 mg over two or three dosages a day. It is also possible to purchase this supplement in a liquid syrup form for those who prefer that method of administration.
There are very few side effects reported with Pyritinol powder and all clinical trials have found it to be safe and well-tolerance. Some side effects that can occur include skin rashes, headaches, nausea and stomach upset. These side effects tend to occur when high dosages of the supplement are used and can be prevented by reducing your dose.
In rare cases, Pyritinol may cause an allergic reaction so you should start with a small dosage first to ensure this does not affect you.
One study in 2004 found that taking Pyritinol Hydrochloride caused liver damage in combination with other drugs for various diseases. For this reason, it is important to speak to your doctor about any potential drug interactions before you decide to buy Pyritinol online for personal use.
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- Hindmarch I, Coleston DM, Kerr JS. Psychopharmacological effects of pyritinol in normal volunteers. Neuropsychobiology. 1990
- Toledano A, Bentura ML. Pyritinol facilitates the recovery of cortical cholinergic deficits caused by nucleus basalis lesions. J Neural Transm Park Dis Dement Sect. 1994
- Knezevic S, Mubrin Z, Risberg J, Vucinic G, Spilich G, Gubarev N, Wannenmacher W. Pyritinol treatment of SDAT patients: evaluation by psychiatric and neurological examination, psychometric testing and rCBF measurements. Int Clin Psychopharmacol. 1989
- Tazaki Y, Omae T, Kuromaru S, Ohtomo E, Hasegawa K, Mori A, Kurihara M, Kutsusawa N, Okada T. Clinical effect of Encephabol (pyritinol) in the treatment of cerebrovascular disorders. J Int Med Res. 1980
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- Lun A, Gruetzmann H, Wustmann C, Szuesz L, Dominick B, Horvath G, Fischer HD, Nagy I, Gross J. Effect of pyritinol on the dopaminergic system and behavioural outcome in an animal model of mild chronic postnatal hypoxia. Biomed Biochim Acta. 1989
- Herrmann WM, Kern U, Röhmel J. Contribution to the search for vigilance-indicative EEG variables. Results of a controlled, double-blind study with pyritinol in elderly patients with symptoms of mental dysfunction. Pharmacopsychiatry. 1986
- Greiner HE, Haase AF, Seyfried CA. Neurochemical studies on the mechanism of action of pyritinol. Pharmacopsychiatry. 1988
Article last updated on: March 18th, 2018 by Nootriment
1 Comment
Eu gostaria de saber o preço do Encefabol de 100 mg. As informações deste medicamento são muito bõas.