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Rasagiline, also known as Azilect and AGN 1135, is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson’s disease or as an adjunct therapy in more advanced cases.
It is highly selective for MAO type B over type A, by a factor of fourteen. This is a relatively new synthetic compound that was recently (2006) approved by the FDA as a treatment for Parkinson’s disease. Today, it is considered to be one of the primary MAO inhibitors.
This drug was developed in the early 2000’s by a team of Israeli researchers working with Teva Pharmaceuticals Ltd. First presented to the FDA in 2004, it is now one of the most commonly used Parkinson’s medications and treatments in the world. In fact, this is its only purpose and use: to treat the symptoms and slow the progression of the disease.
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Rasagiline Effects:
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The main method of action for Rasagiline revolves around its influence upon the neurotransmitter called Dopamine. When a person has Parkinson’s, Dopamine levels are significantly reduced.
Since this neurotransmitter is critical to the control of mood and movement, it is no wonder why people with this disease develop problems with motor skills and control over movements.
One of the reasons for the Dopamine not reaching the brain in proper amounts is due to the presence of MAO enzymes in the brain.
MAO-B metabolizes and breaks down Dopamine before it reaches its destination. In fact, this enzyme ONLY metabolizes Dopamine and nothing else.
Essentially, Rasagiline works by stopping the production of MAO-B enzymes. This, of course, leads to more Dopamine being able to reach its normal destination and function properly.
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It is also interesting to note that this supplement is chemically similar to methamphetamine. In fact, as it breaks down the pathway eventually leads l-methamphetamine derivatives, even some that have been associated with cardiac and psychiatric effects in some people.
However, the main metabolite is not amphetamine related, so many experts feel that this supplement is better tolerated by more people.
Rasagiline Benefits:
This drug is one of the most effective and most widely used treatments for Parkinson’s disease. However, it is also considered to be a very effective as a means to protect the nerves within the brain.
It is thought to defend against neurotoxins that attack nerve function. This includes things like SIN-1, Glutamate, N-Methyl-4-Phenyl-1, and even a number of beta amyloid proteins.
While the causes of Parkinson’s disease are still unknown, Rasagiline is a drug that can help to improve a number of the associated symptoms. These include tremor, stiffness, and even slow movement. The reason for these improvements is primarily due to the increased Dopamine due to the elimination of those MAO-B enzymes.
This supplement may be even more effective when used in combination with other supplements which contain Levodopa. It seems that these together may have a synergistic effect, making both of them work better together than when taken separately.
While this drug can be used at any point during the progression of Parkinson’s, it is most commonly used during the beginning stages of the disease. Long term effects at this point have not really been determined, but it appears to be much more effective the sooner it is used.
Rasagiline Dosage:
This is a very powerful drug and it is effective in very tiny amounts. It should be used in conjunction with treatment by a medical professional.
Given that, the recommended dosage is typically between .5 and 1.0 mg per day. Normally, when it is used in combination with other medications and treatments, you would expect to take the lower dose.
Rasagiline can be taken on an empty stomach or with food. Check with your doctor to see which way they recommend. Also, you should never take a double dose of this medication, since larger dosages can potentially cause problems, even death.
Rasagiline Side Effects:
One of the positive aspects of Rasagiline use is the fact that there is no risk of developing tolerance. In other words, it can be taken every day. There are a number of side effects which have been associated with this supplement, including headache, drowsiness, joint pain, and dizziness.
Some people may even experience an allergic reaction that may cause hives, airway constriction, swelling of the throat, tongue, or eyes. There may also be some intestinal problems like diarrhea, vomiting, and constipation. There have also been reports of mild vertigo, hallucinations, and sensory impairments.
Rasagiline Review:
Rasagiline is a drug known to work for those who are suffering from Parkinson’s disease. Some people have looked into using Rasagiline as a smart drug with neuroprotective properties or a life extension supplement. However, this should not be undertaken without medical guidance.
Rasagiline is often compared to the nootropic drug Deprenyl or Selegiline which are also dopamine boosters used in the treatment of Parkinson’s. If you are looking for a dopaminergic nootropic supplements for mood enhancement purposes, it is generally recommended to use other compounds like Mucuna Pruriens, Tyrosine or Phenylethylamine HCL instead of taking drugs like Rasagiline.
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Article last updated on: March 5th, 2018 by Nootriment
1 Comment
What do you think about adding Tribulus Terrestris when using Rasagiline and Ropinerole for Parkinson’s? This was suggested for my partner.