Resveratrol Dosage Recommendations for Anti-Oxidants, Inflammation & Weight Loss

Resveratrol dosage recommendations vary according to the purpose it is being used for.

This natural supplement is commonly used for its anti-aging effects, to promote heart and brain health, to increase athletic endurance, to support weight loss, to lower cholesterol and to prevent against oxidative damage.

Each of these applications will require a different optimal dosage, as determined based on research.

Resveratrol supplements sold online come in many different pre-formulated dosages and combinations with other ingredients. The active form of Resveratrol, Trans-Resveratrol has more health benefits and is more chemically stable than the inactive form Cis-Resveratrol. It is the kind used in most oral supplements as well as topical creams.

Resveratrol

Anti-Oxidant Supplement

Anti-Aging

Heart Health

Energy Metabolism

How It Works:

• Anti-oxidant used to fight signs of aging
• Improves mitochondrial health & energy metabolism
• Reduces inflammation & increases blood flow

Dosage:

Between 150 - 500 mg per day

Safety:

Rated Likely Safe

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What is the Best Resveratrol Dosage?

Resveratrol has antioxidant properties and seems to protect against the negative effects of obesity such as LDL bad cholesterol, hardening of the arteries, high blood pressure, and Diabetes.

It is an anti-inflammatory for chronic inflammation, such as age-related deafness.

It also delays the onset of Alzheimer’s and increases blood flow in the brain.

It also has anti-cancer properties.

It is estimated that the Spanish population has an intake of 0.2mg daily, (98.4%) from wine. North Americans tend to have the least levels in the diet. This is why the Mediterranean diet is recommended by some experts.

Red wine is a source of resveratrol, as well as berries, red grape skins, nuts and pomegranates. The Japanese Knotweed Polypodium Cuspidatum plant is often used as a source of resveratrol in supplements, because it can be harvested year round.

However, grape skin extract is a superior source as it does not contain the compound emodin which can cause diarrhea and stomach discomfort.

How to Use Resveratrol

There is a circadian rhythm with resveratrol absorption. It appears to be more dose-efficient in the morning than in the evening.

There also appears to be individual variations between dosages. This isn’t so pronounced at lower doses such as 25mg where there may be a 2-fold difference.

But this doubling effect as the dosages increases, especially with large mega doses is a cause of concern. This is why is better to start out with smaller doses to begin with to see what effect the supplement is going to have on the body chemistry.

The half-life of the resveratrol molecule is in the range of 1-3 hours. It can be extended for another 2-5 hours with multiple doses.

Using Resveratrol to Boost Longevity

For control of high blood pressure, lower doses of the supplement have proven effective. Rats were given 5mg/kg resveratrol which compares to the lower human equivalent of 3.3mg occurring in wine consumption.

A study published in June 2011 in Pathobiology of Aging and Age-related Diseases (PBA) found mice with allergic airways disease were treated with 12.5 mg/kg resveratrol and exhibited reduced tissue inflammation.

For general health benefits for cardiovascular health, insulin sensitivity, and longevity, dosages between 150-445mg have been used. Resveratrol has been shown to increase insulin sensitivity when supplemented with obese persons at 150mg daily as measured by HOMA index and measured a 13.3% improvement over 30 days.

Resveratrol appears to benefit glucose metabolism, with lower doses needed for those with metabolic conditions such as being diabetic. Higher doses were needed for those in pre-clinical disease states.

In the treatment of obesity, a high dose resveratrol supplement of 200-400mg a day resulted in significant resistance to weight gain. Taking this supplement increased thermogenesis, mitochondrial biogenesis, and aerobic capacity in administered rats.

Resveratrol also has the ability to inhibit fatty acid synthase and to inhibit phospdiesterase enzymes in fat metabolism.

This action is complimented when combined with Caffeine and other fat loss agents like Green Tea Catechins. Some Reseveratrol products use this combination to produce a supplement for weight loss.

Supplementing for cerebral blood flow requires a dose in the 250-500mg range. For aromatase inhibition for anti-cancer applications, an equivalent human dosage of 500mg has been used in studies.

Topically it used to treat cold sores, skin cancer and ultraviolet damage and can be used safely for up to 30 days. It has also shown promise in the treatment of oesophageal cancer and is being studied for the treatment of prostate cancer.

Safe Usage of Resveratrol

In the terms of safety, Resveratrol doses appears to be well-tolerated by rats continuously at dosages up to 100mg/kg bodyweight, 400mg/kg bodyweight, and up to 750mg/kg bodyweight when using the trans-resveratrol supplement.

People taking antiviral or antifungal medications or blood thinners or blood pressure medicine shouldn’t take this supplement. It may also affect the potency of NSAID painkillers or medications that change in the liver.

It is also thought to react with the herbal supplements St. John’s Wort, Garlic and Ginkgo Biloba extract.

Because it is not fully understood for its role in the treatment of cancer, it shouldn’t be taken if you are having cancer treatment. It should be discontinued two weeks before surgery.

It is thought to be safe during pregnancy and breastfeeding if not sourced from wine.

The best Resveratrol dosage for human equivalence is still being studied based on results from laboratory studies. There are some advocates who think a regular 5 to 10 mg dose for healthy adults would increase the quality and perhaps the longevity of life. It has great potential as a supplement especially in an aging population.

Studies seem to show it helps delay the onset of debilitating conditions such as Alzheimer’s and Diabetes as well as having anti-cancer applications.

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