- SAMeMood SupplementMoodCognitive HealthJoint Function
How It Works:
Top SAMe Products* ❯View User Ratings* ❯*Affiliate LinksOVERVIEW: S-adenosyl-L-methionine (SAMe) is formed in the body from methionine and adenosine triphosphate (ATP). It plays a role in the immune system and the production and breakdown of important neurotransmitters like serotonin, melatonin, and dopamine. READ MORE...USED FOR: Depression, Anxiety, Heart disease, Fibromyalgia, Osteoarthritis, Dementia, Alzheimer's disease, Chronic fatigue syndrome (CFS), Liver disease, ADHD, Tendonitis, Pain reduction.MECHANISM: The widespread actions of SAMe are mainly due to its ability to increase methylation by being a methyl donor. This leads to stimulating DNA repair and cell division, controlling gene transcription, and forming phospholipids and neurotransmitters.DOSAGE: 400-1600 mg daily, depending on purpose of use.SIDE EFFECTS: Rated as Likely Safe when used orally and appropriately. SAMe is generally well tolerated; some mild side effects have been reported, including nausea, gas, diarrhea, headache, anxiety, insomnia, and a skin rash.INTERACTIONS: Antidepressant drugs, Dextromethorphan, Levodopa, Meperidine, MAOIs, Pentazocine, Tramadol. May interact with herbs and supplements that increase serotonin levels, including 5-HTP, L-tryptophan, and St. John's wort.RELATED SUPPLEMENTS: Mucuna Pruriens, Sulbutiamine, Phenylalanine, Phenylethylamine, 5-HTP, L-Tryptophan, L-Theanine, SAMe, GABA, Inositol, Rhodiola Rosea, St. John's WortTop SAMe Supplements
- Enhances mood & promotes cognitive health
- Essentual for dopamine, serotonin & norepinephrine metabolism
- Promotes joint comfort & liver health
Back when I was severely depressed I literally took anything that was labeled as an “antidepressant” and leaned more towards the natural ones.
Immediately after seeing a Nature-made blister pack of SAM-e at Wal-Mart on sale I purchased it did a little research and without hesitation popped the recommended dosage.
30 minutes later the effects started to kick in. I felt lighter and more warm almost like a dose of 5-HTP, it was nice and subtle until about 45 minutes to an hour in my vision started warping and shifting. It was like I just took 6 shots and was the drunkest I’ve ever been but could still think…. until it started peaking then I felt VERY disoriented and confused I had the lay down. After an hour from the peak the effects wore off, I felt super out of it for the next few hours.
I stopped taking it until about a year after I purchased it, I knew it was going to expire soon so I gave it another chance. Literally the exact same thing happened, nothing changed from what I had experienced the first time. Dizzy and confused.
If anyone can tell me what happened that would be great, I’m nearly 100% certain I wasn’t taking any other medication or supplement during this ordeal so I doubt it was an interaction. I’ve taken so many supplements in my life but SAM-e is the only one I’ve taken that gave me terrible side effects. Anyone else?
Thanks for the feedback. I have never tried it but am considering. I guess I will try it small doeses first, based on your experience.