SAM-e Supplement Effects, Review and How to Take

SAM-e supplements are often used as natural treatment alternatives for depression and arthritis. Taking a SAM-e supplement may support emotional well-being by helping to balance neurotransmitters in the brain. This supplement may also support joint function and reduce pain caused by osteoarthritis.

S-adenosyl-L-methionine, which is also known as “SAM-e,” is a molecule that was first discovered in the early 1950s. It is produced naturally within the human body from the precursors adenosine triphosphate and L-methionine.

Although SAM-e has not yet been approved by the United States Food and Drug Administration for the treatment of any conditions, studies have shown that the supplement may have specific beneficial effects on the human body.

Studies have also shown that side effects of SAM-e are rare and that the supplement is likely safe when consumers use it appropriately. Below is some basic information about the SAM-e supplement, its uses, how it affects the body, potential side effects, dosages and contraindications.

SAMe

Mood Supplement

Mood

Cognitive Health

Joint Function

How It Works:

• Enhances mood & promotes cognitive health
• Essentual for dopamine, serotonin & norepinephrine metabolism
• Promotes joint comfort & liver health

Dosage:

Between 400 - 1600 mg per day

Safety:

Rated Likely Safe

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View User Ratings* ❯

SAM-e Supplement Effects

Studies have shown that SAM-e may have some important effects on the body. It is found in significant amounts in both the brain and the liver, and it plays a role in the synthesis of several neurotransmitters, including serotonin, dopamine and norepinephrine.

In the liver, SAM-e aids in detoxification by increasing levels of the critical antioxidant glutathione and supporting healthy methylation enzymatic processes. Furthermore, SAM-e promotes the synthesis of L-cysteine and phosphatidylcholine, both of which support the health of the liver.

In addition, studies have shown that SAM-e may help to promote proper joint function. In 2002, an agency within the U.S. Department of Health and Human Services conducted a research study that found that SAM-e could effectively help to maintain stable joint function without causing any significant side effects.

SAM-e is also involved in the synthesis of glucosamine, which is important for joint health. Consuming a SAM-e supplement can increase levels of this molecule in synovial fluid, resulting in anti-inflammatory and pain relieving effects.

SAM-e Supplement Uses

According to the Natural Medicines Database, SAM-e has been used for a number of purposes. Some of these purposes include:

• Osteoarthritis
• Fibromyalgia
• Heart disease
• Anxiety
• Depression
• Bilirubin metabolism
• Porphyria
• Chronic lead poisoning
• Migraine headache
• Seizures
• Spinal cord injury
• Multiple sclerosis
• Liver disease
• Chronic fatigue syndrome
• Alzheimer’s disease
• Attention deficit-hyperactivity disorder
• Premenstrual dysphoric disorder
• Premenstrual syndrome
• Parkinson’s disease
• Dementia
• Lower back pain
• Tendonitis
• Bursitis

Although some of these uses are supported by research, others are not. However, research into the efficacy of SAM-e for various purposes is ongoing.

SAM-e Supplement Side Effects

The Natural Medicines Database reports that SAM-e has been well tolerated in past clinical trials, and side effects are mild.

For example, some people taking SAM-e may experience gastrointestinal problems, such as nausea, as well as skin rashes. People with bipolar disorder may also experience hypomania and/or increased anxiety while taking this supplement.

SAM-e may cause enhanced side effects for people with Parkinson’s disease. Serious SAM-e side effects and overdose have not yet been reported in the literature. However, adverse reactions are still possible.

If you experience any severe side effects or acute reactions while taking SAM-e, discontinue the supplement and talk to your doctor.

SAM-e Supplement Dosages

Because the FDA has not approved SAM-e for the treatment of any ailment, no standardized dosing guidelines for SAM-e supplements exist. However, the Natural Medicines Database reports that the dosages below have been used in past research studies with little to no adverse effect.

• Osteoarthritis – 600 to 1200 mg in divided doses daily for up to 84 days.
• Neurologic disorders – Up to 800 mg daily.
• Depression – 800 to 1600 mg daily for six weeks.
• Smoking cessation – 400 to 800 mg twice daily for eight weeks.
• ADHD – Up to 2400 mg daily in divided doses for a maximum of four weeks.
• Cholestasis – 1600 mg daily for up to two weeks.
• Fibromyalgia – 400 mg twice daily.
• Liver disease – 400 to 1200 mg daily for up to 24 weeks.
• Schizophrenia – Up to 80 mg in divided doses daily for a maximum of seven weeks.
• Sexual function – Up to 1600 mg in divided doses daily for six weeks.

Although these dosages have been well tolerated in past studies, they may not be the proper dosage for you. When beginning SAM-e for the first time, talk to your doctor to find out how much you should take.

In general, it is best to start with a lower dosage of SAM-e and gradually increase the amount you take until you have reached your desired level of effectiveness and/or the maximum dosage recommended by your physician.

How to Take SAM-e Supplements

You can take SAM-e in an intravenous, injectable or oral form. Most people taking SAM-e over the counter take an oral formulation of the supplement.

Regardless of the purpose for which you are using SAM-e, always follow the instructions on the manufacturer’s label, and never exceed the maximum dosage recommended by your doctor.

Keep in mind that SAM-e may interact with certain prescription medications, including:

• Antidepressants (including SSRIs)
• Dextromethorphan
• Levodopa
• Demerol
• Monoamine Oxidase Inhibitors
• Pentazocine
• Tramadol

SAM-e may also interact with any supplement that increases the level of serotonin in the body. Talk to your doctor before taking a SAM-e supplement if you are taking any of these other medications or supplements.

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