- SAMeMood SupplementMoodCognitive HealthJoint Function
How It Works:
Top SAMe Products* ❯View User Ratings* ❯*Affiliate LinksOVERVIEW: S-adenosyl-L-methionine (SAMe) is formed in the body from methionine and adenosine triphosphate (ATP). It plays a role in the immune system and the production and breakdown of important neurotransmitters like serotonin, melatonin, and dopamine. READ MORE...USED FOR: Depression, Anxiety, Heart disease, Fibromyalgia, Osteoarthritis, Dementia, Alzheimer's disease, Chronic fatigue syndrome (CFS), Liver disease, ADHD, Tendonitis, Pain reduction.MECHANISM: The widespread actions of SAMe are mainly due to its ability to increase methylation by being a methyl donor. This leads to stimulating DNA repair and cell division, controlling gene transcription, and forming phospholipids and neurotransmitters.DOSAGE: 400-1600 mg daily, depending on purpose of use.SIDE EFFECTS: Rated as Likely Safe when used orally and appropriately. SAMe is generally well tolerated; some mild side effects have been reported, including nausea, gas, diarrhea, headache, anxiety, insomnia, and a skin rash.INTERACTIONS: Antidepressant drugs, Dextromethorphan, Levodopa, Meperidine, MAOIs, Pentazocine, Tramadol. May interact with herbs and supplements that increase serotonin levels, including 5-HTP, L-tryptophan, and St. John's wort.RELATED SUPPLEMENTS: Mucuna Pruriens, Sulbutiamine, Phenylalanine, Phenylethylamine, 5-HTP, L-Tryptophan, L-Theanine, SAMe, GABA, Inositol, Rhodiola Rosea, St. John's WortTop SAMe Supplements
- Enhances mood & promotes cognitive health
- Essentual for dopamine, serotonin & norepinephrine metabolism
- Promotes joint comfort & liver health
I have played with different racetams and as I have ADHD, have taken both adderall and concerta, and SSRIs. SAMe has been more affective than any cognitive enhancer I’ve taken, and the effect has been as noticable to me as adderall is when you take it (though SAMe does take a few days to work), not that they do the same thing, but I’m talking about how noticeable the results are. After taking SAMe my depression totally shifted gears for the positive, where I could only think the same thoughts over and over, I suddenly felt free to let my mind go where it wished. I noticed a better result with SAMe than with Lexapro, and that was at 400mg/day. When I skip a dose, I can feel it a few days later when my mood and thinking ability dips. I can’t get over the fact that this isn’t being touted as the #1 nootropic/mood enhancer for depression, and that there isn’t more information on it in nootropic circles (It did have a huge nootropic affect by alleviating depression, creativity and intelligence-wise, in fact, the largest of any cognitive enhancer I’ve taken. I was very pleasantly surprised). I actually learned about it from a psychological journal.
TL;DR If you have depression, and all these posts aren’t meaning anything to you and you just want to feel better, SAMe is what you’ve been looking for.
Important to note, though, it doesn’t have any real affect on anxiety, except possibly for thought loops. You’re going to have to get help for that elsewhere.
Thanks for sharing your review! It would be great to know what dosages of SAMe you are using and whether you are stacking it with anything or using it on its own.
You say ” it may be just as effective as many anti-depressant medications”, many studies have found this to also be true of a sugar pill (ie placebo) vs rx anti-depressants. Just sayin’………. ;-)
Which studies are you referencing, Mark? The author her/himself ought to cite their source(s) to substantiate the reliability of meaningful claims as that. If anything else, it helps us the readers to be accurately and well-informed.