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How It Works:
Top Serotonin Boosters* ❯View User Ratings* ❯*Affiliate LinksWHAT IS IT: Serotonin, or 5-Hydroxytryptamine, is a compound that acts as a neurotransmitter and hormone in the body. It is produced in the body from the amino acid Tryptophan. 90% of the body's Serotonin is found in the gastrointestinal tract where it acts as a hormone, and the remainder acts as a neurotransmitter in the central nervous system and brain.HOW IT WORKS: Serotonin in the bowels controls intestinal peristalsis (rhythmic contracts involved in digestion). In the central nervous system Serotonin acts as an inhibitory neurotransmitter, relaying messages between neurons and preventing over-excitement of neurons. Serotonin is not capable of passing the blood-brain barrier and must be produced in the brain to act there.WHAT IT AFFECTS: Serotonin is involved in the regulation of mood, learning, appetite, digestion, social behaviors, libido, sleep and memory. In some cases, low Serotonin levels have been associated with mood disorders including depression and anxiety.SUPPLEMENTS USED: Serotonin cannot be taken directly as a supplement to have effects in the brain. Supplements with Serotonin boosting effects are taken instead, including the following.5-HTP: 5-HTP is the direct precursor to Serotonin. 5-HTP can cross the blood-brain barrier and then is used to make Serotonin in the brain.
- Increases Serotonin levels in the brain
- Enhances mood and alleviates stress
- Improves sleep and regulates appetite
Dosage: 50-300 mg per day.
Side Effects: Nausea, Heartburn, Diarrhea, Vomiting, Abdominal pain.L-TRYPTOPHAN: L-Tryptophan is an essential amino acid that is an indirect precursor to Serotonin. Tryptophan is metabolized in the liver into 5-HTP, which then travels to the brain and is converted into Serotonin.
Dosage: 6-12 g split into 3-4 doses per day.
Side Effects: Nausea, Heartburn, Diarrhea, Vomiting, Abdominal pain.SAM-e: SAM-e is a molecule that is necessary for the production of Serotonin in the body.
Dosage: 400-1200 mg per day.
Side Effects: Nausea, Skin rash, Weight loss, Low blood pressure, Sleep issues.L-THEANINE: L-Theanine is a non-dietary amino acid that is found in green tea leaves. L-Theanine may boost Serotonin levels and reduce levels of the excitatory neurotransmitter Glutamate.
Dosage: 100-250 mg per day.
Side Effects: Stomach upset, Low blood pressure.RHODIOLA ROSEA: Rhodiola rosea extract works in the body by modulating the enzyme monoamine oxidase. This enzyme metabolizes Serotonin. When it is inhibited, Serotonin synthesis increases.
Dosage: 200-1000 mg per day, taken 1-3 times per day.
Side Effects: Dizziness, Dry mouth, Restlessness, Insomnia, Irritability.Top Serotonin Supplements
How can you talk about serotonin deficiency when there has never been a valid way to measure serotonin in the body, and especially in the brain? It’s a reductionist, pseudoscientific concept.