Sulbutiamine For Anxiety & Social Anxiety

If you are experiencing anxiety, Sulbutiamine is one of many supplements that users have reported works on the underlying chemical imbalances that cause this disorder.

It is reviewed as being especially ideal for individuals with social anxiety as well as for people who feel that their anxiety is getting in the way of productivity and optimal focus.

While Sulbutiamine does not display the typical characteristic effects of an anxiolytic compound, it is noted for a positive effect on mood and attention switching.

For cases of social or performance anxiety, this nootropic is observed to increase confidence, provide additional energy and make it easier to block out negative thoughts. It is also said to improve verbal fluidity, making it easier and more enjoyable to talk in group settings.

Sulbutiamine

Nootropic Supplement

Alertness

Mood

Cognition

How It Works:

• Heightened alertness, focus & energy
• Supports memory & mental performance
• Promotes mood through dopaminergic activity

Dosage:

Between 250 - 750 mg per day

Safety:

Rated Possibly Safe

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Sulbutiamine Overview

Sulbutiamine (also known as Arcalion) is a synthetic variety of vitamin B1, or Thiamine. It is technically considered to be a dimer of two modified Thiamine molecules.

It is a lipophilic compound which is able to cross the blood-brain barrier much more readily than Thiamine. This supplement was developed in Japan and is the result of an effort to develop a more bioavailable molecule of vitamin B1.

By increasing its lipophilicity, more of it actually reaches the brain, resulting in better energy utilization as well as improved nerve function.

How Does Sulbutiamine Work?

Sulbutiamine works by crossing over the blood-brain barrier and then entering into the central nervous system. Once this happens, it leads to an increase in the levels of both Thiamine and Thiamine esters within the brain. Sulbutiamine supplements are able to selectively target the areas of the brain which are known to be involved in conditions like anxiety.

Also within the mechanism of action for Sulbutiamine is an interaction with the receptor sites and transmission systems for certain neurotransmitters used to control behavior. This includes Acetylcholine, Dopamine, and Glutamate.

All of these brain chemicals are involved in our most basic cognitive processes that determine how we feel, what we focus on, and the way we think.

Dopamine, for example, is directly related to our mood and is typically released as a response of the reward system in the brain. Acetylcholine and Glutamate are both involved in the ability to form and retrieve memories, but Acetylcholine also plays a role in executive function and the ability to concentrate or block out certain stimuli.

Sulbutiamine & Anxiety

Anxiety occurs when your neurons begin firing at a higher, uncontrolled rate.

You may feel like you are experiencing a million thoughts at once without being able to focus on any single one. Individuals often describe being fixated on broad negative possibilities or feeling a general sense of foreboding.

This is accompanied by symptoms of stress as well as panic and the inability to change your focus or control your thoughts. Anxiety can manifest itself in physical signs and make it difficult to maintain a normal sleep schedule.

Anxiolytics usually work on the GABA pathways in the brain, causing the rate of firing for your neurons to be slowed. This allows the brain to relax and makes your mind less sensitive to negative thought loops. However, these supplements can often lead to sedative-like responses in the body, resulting in drowsiness or difficulty concentrating.

Sulbutiamine is not an anxiolytic in this sense. Instead, it is known to produce a positive mood by working in conjunction with dopamine receptors. It can also increase energy levels, helping to combat some of the fatigue that may come with a panic attack.

Users describe it as providing stimulation that can be channeled or more appropriated focused due to Sulbutiamine’s positive effect on executive functions. Sulbutiamine is also described as alleviating stress, giving you productive levels of energy.

There are some situations in which Sulbutiamine can have a negative effect on General Anxiety Disorder. If you feel like this nootropic is making you too energetic and causing greater anxiety, consider replacing it with something else or stacking it with a nootropic like Phenibut, 5-HTP, or Aniracetam.

Sulbutiamine & Social Anxiety

Where Sulbutiamine really shines is when it is used for occasional shyness, performance anxiety, as well as anxiety in social settings. Numerous user reports indicate that taking this supplement before planned social encounters helps to reduce the anxious feelings and even physical discomfort when meeting or interacting with new people.

It seems to be able to lower inhibitions and allow users to feel more comfortable speaking as well as improving conversational ease. Much of this is attributed to the boost in confidence and mental drive that Sulbutiamine gives its user. While the fear may still remain, this Thiamine derivative is said to make it easier to block out negative thoughts so that you can focus on the present moment.

Using Sulbutiamine for social anxiety may be more effective when it is taken in conjunction with other compounds such as Aniracetam, Choline or Adrafinil.

Research on Sulbutiamine use for anxiety is limited, and more research is needed, especially large-scale human trials. At this time Sulbutiamine is available as a dietary supplement only, and the FDA has not approved Sulbutiamine as a drug to prevent or treat any conditions.

Sulbutiamine Effects

Some individuals with General Anxiety Disorder may find that Sulbutiamine’s stimulant-like properties are not well suited for their personal anxiety.

Other nootropics that are also used for anxiety (like Phenibut or Picamilon) typically work by promoting the brain to relax and curb excitability, and may be a better match.

In small doses, Sulbutiamine may have some effect on reducing thoughts of stress and negative feelings. However, Sulbutiamine in larger doses can increase mental activity, but in a channeled manner. This makes it suitable for use as a “smart drug” by individuals with anxiety who need to concentrate and be productive.

But it should not be used in the evening as it may interfere with sleep, or at periods of time when the brain is particularly anxious as it may exacerbate those events.

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