Sulbutiamine: Side Effects, Tolerance, & Withdrawal Concerns

Before they begin using this supplement, many users wonder what Sulbutiamine side effects are there?

Sulbutiamine is known for having a positive effect on mood and the ability to focus, but many supplements that act in this way are known to carry a risk of addiction, tolerance, and withdrawal.

Before you decide to use this nootropic, it is important to understand the risk of Sulbutiamine side effects.

While this derivative of vitamin B1 (Thiamine) is considered to have low risk of side effects when used appropriately, there may be negative effects if it is abused or taken in large amounts.

Let’s take a closer look at the safety profile of Sulbutiamine as well as the risk of dangerous side effects.

Sulbutiamine

Nootropic Supplement

Alertness

Mood

Cognition

How It Works:

• Heightened alertness, focus & energy
• Supports memory & mental performance
• Promotes mood through dopaminergic activity

Dosage:

Between 250 - 750 mg per day

Safety:

Rated Possibly Safe

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Sulbutiamine History

Sulbutiamine was developed in Japan in order to be a more efficient version of Thiamine.

The Japanese diet did not traditionally provide enough of this vitamin, resulting in higher rates of medical conditions associated with B1 deficiency.

Vitamin B1 plays an important role in providing the brain with energy as well as the proper functioning of enzymes and the transportation of fats and proteins through the body.

Sulbutiamine is capable of mimicking the effects of Thiamine, but on a more concentrated level. It is better able to cross over the blood-brain barrier and enter into the central nervous system. As such, it leads to a stronger series of benefits related to energy and mood.

Sulbutiamine is a fat soluble vitamin derivative, so it works best when taken with food. This makes it distinct from Thiamine which is water soluble and is flushed out of the body if it is not regularly replaced. Using Sulbutiamine raises levels of Thiamine phosphate esters in the brain at a much faster rate.

Sulbutiamine has other unique properties as well and is noted to increase the number of dopamine receptors in the brain. Since Dopamine is involved in pleasurable sensations as well as our ability to focus and control our desires, Sulbutiamine has a greater propensity to boost productivity and concentration than Thiamine itself.

Sulbutiamine Side Effects 

While Sulbutiamine is generally very well-tolerated, there are some side effects to be aware of. In very rare cases, users reported developing eczema-like symptoms and skin rashes. Most of these occurrences have been moderate and short-lived, but in some instances this side effect may be more serious. The best way to avoid this is to control your dosage and ask your doctor about other risk factors that Sulbutiamine may exacerbate.

Some reviews point out Sulbutiamine side effects related to the brain and mood. There have been user reports of this supplement causing mood swings and negatively affecting overall mood. This may be from taking too much, or perhaps having receptor locations within the brain that are overly sensitive to some of the effects of this supplement.

Sulbutiamine also is known to have a negative outcome in some individuals with bipolar mood disorder. It should not be combined with bipolar medication and anyone suffering from this condition should speak to their doctor for qualified help.

Several users have reported that taking Sulbutiamine leads to difficulties in falling asleep. It is unclear why certain individuals experience this problem, but it may have something to do with their personal brain chemistry. These individuals may find it takes longer to get to sleep when using Sulbutiamine or that they way up more frequently during the night.

If you find that your sleep-wake cycles are disrupting your normal daily routine, stop using Sulbutiamine or only take it on an occasional basis.

Sulbutiamine is also known to act as an appetite suppressant. While some people might benefit from the added appetite control, others could experience negative outcomes as a result. Anyone with a history of eating disorders or people who are underweight may want to avoid using this nootropic.

It may also have some negative interactions with other drugs, especially antidepressants like selective serotonin reuptake inhibitors. For a full list of Sulbutiamine side effects, you should speak to a health professional that understands your medical history.

It is a good idea in general to avoid long-term use of supplements like Sulbutiamine, instead only using them as needed.

Sulbutiamine & Tolerance

There is some speculation that Sulbutiamine may be addictive, at least for some people. While there has been no conclusive research on the matter, it is known to affect dopamine levels in the brain.

Sulbutiamine actually decreases the amount of Dopamine being released by your neurons, resulting in more dopamine receptors developing in certain areas of the brain.

This is contrary to how most mood enhancers work and it is one of the reasons why most experts think Dopamine is not likely to cause problems of addiction or tolerance. However it is better to be safe than sorry and caution is suggested when taking it on an everyday basis.

The positive effects of Sulbutiamine do seem to wear off quickly if it is used consistently at high dosages. For the most part, this generally affects the mood boosting and energizing properties first. The best way to counter the possibility of tolerance is by avoiding long term use.

Another excellent method is to stack this together with other Nootropic supplements, or to make it part of a cycle. This will keep your body guessing so that your receptor feedback loops do not have enough time tolerance to build-up.

Sulbutiamine Withdrawal Concerns

Addiction and withdrawal concerns are more likely to present themselves in cases where high doses are used. This is also magnified in cases where Sulbutiamine is being taken in combination with anti-psychotic medications.

Studies have also shown that by using Sulbutiamine for 10 days straight, a user can expect to undergo between 2 to 5 days of withdrawal. We should add that the study upon which those findings were based used 300 mg per kg of body weight as a dose. This is quite a bit larger than the 500 mg average total dosage taken by most users.

To this end, you want to avoid using excessively high doses of Sulbutiamine to prevent any possible symptoms of tolerance or withdrawal. Moderating your use is the best way to prevent the occurrence of possible Sulbutiamine side effects.

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