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Sunifiram is one of the newest nootropics on the market showing very promising initial results. It falls into the ampakine family of nootropic supplements because it is an AMPA agonist.
Some reviews have suggested that it works similarly to Piracetam but it is over 1000 times more potent than Piracetam for the same dosage.
Sunifiram is highly effective at boosting memory function as well as attention span, learning, decision making and alertness.
A lot of initial reviews and user experiences suggest that Sunifiram could become one of the most popular nootropic study aids for improving concentration.
Cognition
Focus
Neuro- plasticity- Stimulates AMPA receptors in the brain
- Promotes focus & mental energy
- Enhances growth of synapses between neurons
What Is Sunifiram?
Related Topics
Sunifiram, also known as 1-benzoyl-4-propanoylpiperazine is a nootropic that was only first researched in the year 2000.
It has a similar chemical structure to Piracetam but initial studies show that it is significantly more potent than this widely used racetam.
Sunifiram so far shows very positive results as memory enhancer and it is currently being investigated for potential treatment of Alzheimer’s and other diseases related to cognitive decline.
User reviews and Sunifiram logs point to the fact that this supplement makes information recall much easier and helps you think more clearly. Sunifiram is being compared to Noopept quite a bit because of their similar potency levels.
Initial observations suggest that Sunifiram is better as a memory booster while Noopept might have an edge on increasing focus and alertness.
Sunifiram Effects and Benefits
Sunifiram works very similarly to other racetams by stimulating many of the same receptors just in different ways. The primary effect of taking Sunifiram is stimulation of AMPA receptors (hence which this drug is considered an AMPAkine).
In clinical trials, patients given the AMPA antagonist NBQX and then given Sunifiram saw increased AMPA receptor activity. AMPA receptors are responsible for how much glutamate is produced in the brain.
Glutamate is perhaps the most important neurotransmitter in the brain, responsible for communicating excitatory transmissions, forming connections between synapses, and for regulating brain cell survival.
Glutamate is highly involved in brain metabolism as well as synaptic plasticity. Too little glutamate and your cognitive abilities will be greatly impaired, resulting in less attention span, poor ability to learn information and difficulty remembering.
Sunifiram can help reverse this by raising levels of glutamate so your brain performance is increased. Especially when engaging in long periods of mental exertion, you will find that Sunifiram makes it easier to remember information and learn new concepts.
Sunifiram also effects levels of acetylcholine in the brain just like Piracetam, Pramiracetam, Aniracetam, Oxiracetam and other racetam nootropics. Studies have established that taking Sunifiram is Cholinergic meaning that it causes more of this neurotransmitter to be released.
Increased presence of Acetylcholine in the cerebral cortex leads to improved thinking, perception, alertness, learning, memory and focus. Acetycholine makes it easier for your left and right brain hemispheres to communicate as well which can cause you to recognize patterns and connections more effectively as well as improve basic social skills like talking in group settings.
Sunifiram Review and Experiences
Individuals who take Sunifiram often report that it feels like a stimulant similar to taking a smart drug like Adderall. Fortunately, Sunifiram does not come with the same negative side effects possible when taking an amphetamine-based ADHD drug such as Ritalin or Adderall.
Sunifiram can dramatically increase energy levels and increase your ability to concentrate. Many people will use Sunifiram for motivation and to help them get over procrastination both for work, school and other tasks. Some individuals have even experimented with Sunifiram as a pre-workout supplement for bodybuilding or weight loss.
Sunifiram Dosage and How to Take
Sunifiram is incredibly concentrated compared even to the strongest racetams like Pramiracetam. You will see positive effects from a dosage as small as 4 mg though many people typically take between 5-8 mg at a time. A Sunifiram dose of 10 mg is more likely to cause a stimulant effect similar to Adderall.
Taking a 10 mg Sunifiram dosing is not toxic and not likely to cause serious negative side effects, however you may experience increased body temperature and perspiration. You should start with a half dose of 3 mg for your first week or so of taking this ampakine nootropic and then only increase the dosage if you feel comfortable.
Where can you Buy Sunifiram Online?
Sunifiram is not widely available for sale in the USA right now, but there are some nootropic websites that will sell it. Typically you will pay around $40 for a 2 gram supply of Sunifiram powder. This might seem expensive compared to other nootropics, but when you consider the incredibly high potency of Sunifiram the price is on par with many other supplements.
Consider trying Sunifiram the next time you buy a nootropic stack and let us know your personal experience with it! If you cannot find Sunifiram for sale online or are wary of using such a new nootropic, Noopept is the best alternative offering a similar potency level and the same range of cognitive benefits.
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- Moriguchi S, Tanaka T, Narahashi T, Fukunaga K. Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor. Hippocampus. 2013
- Moriguchi S, Tanaka T, Tagashira H, Narahashi T, Fukunaga K. Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice. Behav Brain Res. 2013
- Martini E, Salvicchi A, Ghelardini C, Manetti D, Dei S, Guandalini L, Martelli C, Melchiorre M, Cellai C, Scapecchi S, Teodori E, Romanelli MN. Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. Bioorg Med Chem. 2009
- Gualtieri F. Unifi nootropics from the lab to the web: a story of academic (and industrial) shortcomings. J Enzyme Inhib Med Chem. 2015
- Martini E, Norcini M, Ghelardini C, Manetti D, Dei S, Guandalini L, Melchiorre M, Pagella S, Scapecchi S, Teodori E, Romanelli MN. Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. Bioorg Med Chem. 2008
- Romanelli MN, Galeotti N, Ghelardini C, Manetti D, Martini E, Gualtieri F. Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers. CNS Drug Rev. 2006
- Ghelardini C, Galeotti N, Gualtieri F, Romanelli MN, Bucherelli C, Baldi E, Bartolini A. DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer. Naunyn Schmiedebergs Arch Pharmacol. 2002
- Scapecchi S, Martini E, Manetti D, Ghelardini C, Martelli C, Dei S, Galeotti N, Guandalini L, Novella Romanelli M, Teodori E. Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs. Bioorg Med Chem. 2004
- Galeotti N, Ghelardini C, Pittaluga A, Pugliese AM, Bartolini A, Manetti D, Romanelli MN, Gualtieri F. AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). Naunyn Schmiedebergs Arch Pharmacol. 2003
- Guandalini L, Martino MV, Di Cesare Mannelli L, Bartolucci G, Melani F, Malik R, Dei S, Floriddia E, Manetti D, Orlandi F, Teodori E, Ghelardini C, Romanelli MN. Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235. Bioorg Med Chem Lett. 2015
- Martini E, Ghelardini C, Dei S, Guandalini L, Manetti D, Melchiorre M, Norcini M, Scapecchi S, Teodori E, Romanelli MN. Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers. Bioorg Med Chem. 2008
- Martini E, Ghelardini C, Bertucci C, Dei S, Gualtieri F, Guandalini L, Manetti D, Scapecchi S, Teodori E, Romanelli MN. Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent. Med Chem. 2005
Article last updated on: March 13th, 2018 by Nootriment
9 Comments
I dont know where your talking about paying 40 bucks for 2 grams of this stuff, thats crazy. I get 10 grams for 45 bucks from a reputable distributer…
Hey Deeznuts :). You’re right the price of Sunifiram has come down significantly in the past year. This article was originally written in the summer of last year when Sunifiram was not yet being carried by many of the major nootropic vendors. Since that time, prices have definitely dropped.
Can anyone tell me where is the best place to find this .any contact numbers or official site ? Please let me know .Many thanks and kind regards.Constantin
Dear Constantin, You can find Sunifiram at this link: https://nootriment.com/buysunifiram/
Peak Nootropic. 500 doses for $25/
Been using it a while…i can focus things for longer…object’s color and shape come alive, enhanced, and sharpened. As far as memory I can go back in time in my memories and trace sequence of events much more easily. Also, upon first taking sunifiram there was a clearness of mind.
I am planning on stacking this with Unifiram. Do you ship to the UAE?
Muito esclarecedor informações de muita importancia.
so what would be the effects of taking this with an anticholinergic like Amitriptyline?