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Buy Now on Amazon *Life Extension Super Bio-Curcumin® is a dietary supplement that increases the low absorption of curcumin.
According to its manufacturer, Dolcas-Biotech, LLC, it is up to 7 times more absorbable than other 95% standardized curcumin supplements.
Curcumin is a bioactive extract taken from the rhizomes of turmeric (Curcuma longa) plants. Curcumin demonstrates multiple therapeutic effects in clinical trials.
It has been shown to exhibit immunomodulatory, prodigestive, anti-inflammatory, antioxidant, anticancer and cardioprotective properties
Super Bio-Curcumin is promoted as having, “whole-body health benefits for nearly every organ system.” The manufacturers say that it promotes a healthy inflammatory response, immune function and digestive function.
Life Extension’s Super Bio-Curcumin® supplement comes in 400 mg vegetarian-friendly capsules. This product can be purchased online at Amazon or from other specialty health supplement retailers.
Joints
Health
Anti- Aging- Effective anti-inflammatory supplement
- Shown to improve joint functionality
- Anti-oxidant to supper general health
Turmeric and Curcumin
Related Topics
Turmeric is a plant indigenous to southwest India. Turmeric rhizomes contain roughly 3% curcumin. Curcumin extracts are deep yellow in color; and have bitter, peppery tastes.
Turmeric has been used in foods and as medicine for thousands of years. Dried and ground turmeric powders are used in various curries and culinary sauces and rubs. It is also used to impart yellow color to mustards.
Research now shows that turmeric and curcumin separately demonstrate a wide array of biological actions.
This supplement was commonly used in Ayurvedic medicine to alleviate stomach problems, arthritis, mood disorders and more.
Many of its benefits stem from its ability to inhibit the effects of key inflammatory factors in the body. It is viewed as one of the strongest natural anti-inflammatory compounds available.
According to the Life Extension website, “[Curcumin] can help support brain, breast, pancreas, and even colon health, as well as promote healthy cell division and a healthy inflammatory response.”
Life Extension Super Bio-Curcumin Health Benefits
By providing a highly absorbable form of curcumin, Super Bio-Curcumin may help to support health on several levels. Research shows that curcumin has:
- Induced antidepressant-like effects by increasing BDNF (brain derived neurotrophic factor) inside the hippocampus;
- Impeded overexpression of the inflammatory protein complex, NF (nuclear factor)-kappaB;
- Slowed down arachidonic acid oxygenation to inhibit inflammation;
- Inhibited the activities of interleukin and tumor necrosis cytokines;
- Decreased activities of cyclooxygenase and lipoxygenase;
- Supported healthy bowel function;
- Improved bone and joint health;
Life Extension Bio-Curcumin may also be helpful for strengthening immunity and enhancing cognitive functioning. Research shows that it can inhibit the release of histamine from mast cells. It has also demonstrated certain neuroprotective effects.
Curcumin extract administration has been shown to support pancreatic islet health. The islets of Langerhan synthesize insulin inside the pancreas.
Using a quality curcumin extract is believed to increase sensitivity to insulin and glucose utilization. Some users report significant improvements to blood glucose modulation.
Curcumin is also a potent antioxidant. It seems to naturally balance hormones and provide protection from chemicals that mimic estrogens.
The ingredients in Super Bio-Curcumin also scavenges free radicals from the system, increases SOD (superoxide dismutase) and neutralizes ROS (reactive oxygen species).
Life Extension Super Bio-Curcumin Ingredients
Super Bio-Curcumin from Life Extension contains another Dolcas-Biotech product called BCM-95®. It is a 25:1 turmeric root extract formulation standardized to 95% curcuminoids and essential oils of turmeric.
Each 400 mg capsule of Super Bio-Curcumin is said to provide the equivalent of 2500 mg of other 95% curcumin supplements.
Super Bio-Curcumin is Non-GMO and contains no sugar. It does contain a vegetarian cellulose capsule, silica, stearic acid and microcrystalline cellulose.
BCM-95® and Bio-Curcumin® are registered and patented trademarks in the United States.
Life Extension Super Bio-Curcumin User Reviews
The product website for Super Bio-Curcumin shows a 99% recommendation rating from its consumers.
User reports of health benefits include improvements to mood, digestion, pain, inflammation, weight loss, physical agility and overall health and well-being.
Life Extension Super Bio-Curcumin Side Effects
Turmeric and curcumin do not usually cause any adverse effects when taken appropriately. The most common side effects are upset stomach, dyspepsia, nausea, dizziness and diarrhea.
These effects are rare and pass quickly without intervention. No serious or lasting adverse effects are associated with turmeric or curcumin.
The manufacturer of Super Bio-Curcumin warns against taking it along with anticoagulant or antiplatelet medications. Those with bleeding disorders, gallbladder disorders and/or gallstones should not use this product without their doctors’ permissions.
According to the Natural Medicines Comprehensive Database (NMCD), turmeric may interact with several medication types. Talk to your doctor about using Life Extension Super Bio-Curcumin if you currently use any of the following:
- Cytochrome P450 1A1, 1A2 and/or 3A4 substrates;
- Anticoagulants/antiplatelets;
- P-glycoprotein substrates;
- Sulphasalazine;
- Antidiabetics;
- Norfloxaline;
- Paclitaxil;
- Docetaxel
- Talinolol;
- Estrogen;
NMCD also states that turmeric and curcumin may interact with diseases and conditions including bile duct obstruction, diabetes, GERD (gastroesophageal reflux disease), hormone-sensitive cancers/conditions, infertility and iron deficiencies.
Use caution if combining turmeric or curcumin with herbal supplements with anticoagulant, antiplatelet, hypoglycemic and/or iron-chelating potentials. Some of these herbs include angelica, clove, danshen, ginseng, red clover, ginger, garlic, fenugreek, guar gum, horse chestnut and willow.
Because it can increase the risks of bleeding, stop using turmeric or curcumin at least 2 weeks prior to scheduled surgeries.
Conclusions
Taking a quality curcumin extract supplement may help to improve health by inhibiting some of the harmful effects of excessive inflammation in the body.
Turmeric and curcumin continue to be researched for cancer, heart disease, neurodegenerative disease, joint health, digestion, liver functioning and other therapeutic targets.
Life Extension Super Bio-Curcumin was designed to enhance the absorption of curcumin. It is well-rated by users and appears to be free of any serious or permanent adverse effects.
- Bordoloi D, Roy NK, Monisha J, Ganesan P, Kunnumakkara AB1. Multi-Targeted Agents in Cancer Cell Chemosensitization: What We Learnt from Curcumin Thus Far. Recent Pat Anticancer Drug Discov. 2015 Oct 19. [Epub ahead of print]
- Sarker MR1, Franks S2, Sumien N1, Thangthaeng N1, Filipetto F2, Forster M1. Curcumin Mimics the Neurocognitive and Anti-Inflammatory Effects of Caloric Restriction in a Mouse Model of Midlife Obesity. PLoS One. 2015 Oct 16;10(10):e0140431. doi: 10.1371/journal.pone.0140431. eCollection 2015.
- Ravindran, Jayaraj, Sahdeo Prasad, and Bharat B. Aggarwal. "Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?" The AAPS Journal 11.3 (2009): 495–510. PMC. Web. 24 Nov. 2015.
- Schaffer M1, Schaffer PM, Bar-Sela G. An update on Curcuma as a functional food in the control of cancer and inflammation. Curr Opin Clin Nutr Metab Care. 2015 Nov;18(6):605-11. doi: 10.1097/MCO.0000000000000227.
- Winkler A1, Gessner DK2, Koch C3, Romberg FJ3, Dusel G1, Herzog E4, Most E2, Eder K2. Effects of a plant product consisting of green tea and curcuma extract on milk production and the expression of hepatic genes involved in endoplasmic stress response and inflammation in dairy cows. Arch Anim Nutr. 2015 Dec;69(6):425-41. doi: 10.1080/1745039X.2015.1093873.
- Iranshahi M1, Chini MG2, Masullo M2, Sahebkar A1, Javidnia A3, Chitsazian Yazdi M1, Pergola C4, Koeberle A4, Werz O4,Pizza C2, Terracciano S2, Piacente S2, Bifulco G2. Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors. J Nat Prod. 2015 Nov 20. [Epub ahead of print]
- Kocaadam B1, ?anlier N1. Curcumin, an Active Component of Turmeric (Curcuma longa), and Its Effects on Health. Crit Rev Food Sci Nutr. 2015 Nov 3:0. [Epub ahead of print]
- Lovelace ES1, Polyak SJ2,3,4. Natural Products as Tools for Defining How Cellular Metabolism Influences Cellular Immune and Inflammatory Function during Chronic Infection. Viruses. 2015 Nov 30;7(12):6218-32. doi: 10.3390/v7122933.
- Bharat B. Aggarwal1 and Kuzhuvelil B. Harikumar Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases Int J Biochem Cell Biol. 2009; 41(1): 40–59. Published online 2008 Jul 9. doi: 10.1016/j.biocel.2008.06.010
- Kim SK1, Seok H1, Park HJ1, Jeon HS1, Kang SW1, Lee BC2, Yi J2, Song SY2, Lee SH3, Kim YO4, Chung JH5. Inhibitory effect of curcumin on testosterone induced benign prostatic hyperplasia rat model. BMC Complement Altern Med. 2015 Oct 22;15(1):380. doi: 10.1186/s12906-015-0825-y.
- Prasad S, Aggarwal BB. Turmeric, the Golden Spice: From Traditional Medicine to Modern Medicine. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 13.
- Gupta, Subash C., Sridevi Patchva, and Bharat B. Aggarwal. "Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials." The AAPS Journal 15.1 (2013): 195–218. PMC. Web. 8 Dec. 2015.
- He Y1, Yue Y2, Zheng X3,4, Zhang K5, Chen S6, Du Z7. Curcumin, inflammation, and chronic diseases: how are they linked? Molecules. 2015 May 20;20(5):9183-213. doi: 10.3390/molecules 20059183.
- He YJ, Kuchta K, Lv X, Lin Y, Ye GR, Liu XY, Song HD, Wang LX, Kobayashi Y, Shu JC. Curcumin, the main active constituent of turmeric (Curcuma longa L.), induces apoptosis in hepatic stellate cells by modulating the abundance of apoptosis-related growth factors. Z Naturforsch C. 2015 Nov 1;70(11-12):281-5. doi: 10.1515/znc-2015-4143.
- Shoba G1, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6.
- Nimiya Y1,2, Wang W1, Du Z1, Sukamtoh E1, Zhu J1, Decker E1, Zhang G1. Redox modulation of curcumin stability: Redox active antioxidants increase chemical stability of curcumin. Mol Nutr Food Res. 2015 Nov 26. doi: 10.1002/mnfr.201500681. [Epub ahead of print]
- Al-Karawi D1, Al Mamoori DA2, Tayyar Y3. The Role of Curcumin Administration in Patients with Major Depressive Disorder: Mini Meta-Analysis of Clinical Trials. Phytother Res. 2015 Nov 27. doi: 10.1002/ptr.5524. [Epub ahead of print]
- Chen Q1, Gao Q1, Chen K1, Wang Y1, Chen L1, Li XU2. Curcumin suppresses migration and invasion of human endometrial carcinoma cells. Oncol Lett. 2015 Sep;10(3):1297-1302. Epub 2015 Jul 9.
- Poojan S1, Kumar S1, Verma V1, Dhasmana A2, Lohani M3, Verma MK1. Disruption of Skin Stem Cell Homeostasis following Transplacental Arsenicosis; Alleviation by Combined Intake of Selenium and Curcumin. PLoS One. 2015 Dec 1;10(12):e0142818. doi: 10.1371/journal.pone.0142818. eCollection 2015.
- Du L, Feng X, Xiang X, Jin Y1. Wound Healing Effect of an in Situ Forming Hydrogel Loading Curcumin-Phospholipid Complex. Curr Drug Deliv. 2015 Dec 2. [Epub ahead of print]
- Ding L1, Ma S2, Lou H3, Sun L4, Ji M5. Synthesis and Biological Evaluation of Curcumin Derivatives with Water-Soluble Groups as Potential Antitumor Agents: An in Vitro Investigation Using Tumor Cell Lines. Molecules. 2015 Dec 2;20(12):21501-14. doi: 10.3390/molecules 201219772.
- Huang H1, Chen X1, Li D2, He Y1, Li Y3, Du Z1, Zhang K1, DiPaola R4, Goodin S4, Zheng X1. Combination of ?-Tomatine and Curcumin Inhibits Growth and Induces Apoptosis in Human Prostate Cancer Cells. PLoS One. 2015 Dec 2;10(12):e0144293. doi: 10.1371/journal.pone.0144293. eCollection 2015.
- Li L1, Li H2, Li M2. Curcumin protects against cerebral ischemia-reperfusion injury by activating JAK2/STAT3 signaling pathway in rats. Int J Clin Exp Med. 2015 Sep 15;8(9):14985-14991.
- Ramadan G1, El-Menshawy O. Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis. Int J Rheum Dis. 2013 Apr;16(2):219-29. doi: 10.1111/1756-185X.12054. Epub 2013 Apr 4.
- Velusami CC1, Boddapati SR1, Hongasandra Srinivasa S1, Richard EJ1, Joseph JA1, Balasubramanian M1, Agarwal A1. Safety evaluation of turmeric polysaccharide extract: assessment of mutagenicity and acute oral toxicity. Safety evaluation of turmeric polysaccharide extract: assessment of mutagenicity and acute oral toxicity.
- Chainani-Wu N1. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcumalonga). J Altern Complement Med. 2003 Feb;9(1):161-8.
- Boyanapalli SS1, Tony Kong AN1. "Curcumin, the King of Spices": Epigenetic Regulatory Mechanisms in the Prevention of Cancer, Neurological, and Inflammatory Diseases. Curr Pharmacol Rep. 2015 Apr;1(2):129-139. Epub 2015 Jan 30.
- Witkin JM1, Li X. Curcumin, an active constiuent of the ancient medicinal herb Curcuma longa L.: some uses and the establishment and biological basis of medical efficacy. CNS Neurol Disord Drug Targets. 2013 Jun;12(4):487-97.
- Bandyopadhyay D1. Farmer to pharmacist: curcumin as an anti-invasive and antimetastatic agent for the treatment of cancer. Front Chem. 2014 Dec 23;2:113. doi: 10.3389/fchem.2014.00113. eCollection 2014.
- Zhao G1, Han X1, Zheng S1, Li Z1, Sha Y1, Ni J1, Sun Z1, Qiao S1, Song Z1. Curcumin induces autophagy, inhibits proliferation and invasion by downregulating AKT/mTOR signaling pathway in human melanoma cells. Oncol Rep. 2015 Nov 12. doi: 10.3892/or.2015.4413. [Epub ahead of print]
- Yu CC1, Yang MD2, Lin HY1, Huang AC3, Lin JP4, Kuo CL5, Liu KC6, Liu HC7, Yang ST8, Chung JG9. Bisdemethoxycurcumin (BDMC) Alters Gene Expression-associated Cell Cycle, Cell Migration and Invasion and Tumor Progression in Human Lung Cancer NCI-H460 Cells. In Vivo. 2015 11-12;29(6):711-728.
- Ma J1, Jin X, Yang L, Liu ZL. Diarylheptanoids from the rhizomes of Zingiber officinale. Phytochemistry. 2004 Apr;65(8):1137-43.
- Zheng Z1, Sun Y2, Liu Z1, Zhang M1, Li C1, Cai H3. The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats. Drug Des Devel Ther. 2015 Aug 27;9:4931-42. doi: 10.2147/DDDT.S90147. eCollection 2015.
- Bandyopadhyay, Debasish. "Farmer to Pharmacist: Curcumin as an Anti-Invasive and Antimetastatic Agent for the Treatment of Cancer." Frontiers in Chemistry 2 (2014): 113. PMC. Web. 24 Nov. 2015.
Article last updated on: April 5th, 2018 by Nootriment