Some bodybuilders and powerlifters supplement with Super Cissus RX to enhance their power output levels, as well as increase their lean muscular mass.
Others use it for erectile dysfunction, low libido, menstrual abnormalities, and an array of other health conditions and diseases.
CQ has been beneficially used in various Asian and African cultures for more than a millennium to support joint health.
It has been prescribed in traditional medicinal systems, including Indian Ayurvedic medicine, as a bone healing agent, and to provide relief for painful or irregular menstruation cycles.
Super Cissus RX by USPlabs contains 800mg of Cissus quadrangularis (CQ) extract per capsule. It is commonly recognized today to improve strength training, promote weight loss, and reduce the absorption of lipids and carbohydrates into the blood stream.
Bodybuilders who are in a cutting phase will take Super Cissus RX to help regulate blood sugar and reduce insulin levels. It was even recognized by Tim Ferris in his book The 4 Hour Body as one of the best fat loss supplements.
According to USPLabs, “Super Cissus RX is a unique supplement with multiple benefits from muscle growth to joint health.” Compared to the standard Cissus RX product width contained a 5% standardized extract, this supplement contains a 10% high-potency extract.



- Promotes joint health & pain reduction
- Sedative & muscle relaxing properties
- Supports weight loss & workout recovery
Benefits of Cissus Quadrangularis
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Some of the benefits attributed to Cissus quadrangularis include:
- Boosting the performance of the immune system, thus decreasing the damages incurred via free radical oxidation
- Enhancing overall cardiovascular health
- Encouraging and accommodating generalized bodily detoxification via stimulation of the lymphatic system, and by enhancing the functioning of the liver
- Intensifying sexual desire (libido), and improving premature ejaculation, the inability to gain an erection, and poor endurance levels
- Reducing inflammation in the intestines
Super Cissus RX for Bodybuilders
Super Cissus RX is used by bodybuilders internationally because it is widely believed to improve muscular size and strength when used as part of an appropriate training regimen. This is attributed to the vasodilatory effects of CQ.
Our blood vessels are lined by a thin layer of flattened cells known as the endothelium. Vasodilation is the process by which the endothelium are relaxed. When endothelium relaxes in the heart, lungs and circulatory vessels, blood vessels are able to diametrically expand.
With increased diameter, the vessels are able to transport increased blood volume without causing any increases in systolic or diastolic blood pressure readings. When more blood is delivered with no increased inner-vessel pressure, the heart works less to deliver increased volumes of blood.
More blood delivered means more oxygen and other nutrients, more growth and repair hormones and more of the building blocks of protein are delivered to the muscles and the rest of the body. With increased nutrients and hormones delivered throughout the body, enhanced healing, muscular size gains, muscular strength gains, detoxification, lipid reduction, and various other benefits may be experienced.
Super Cissus RX and Sexual Enhancement
Taking a Super Cissus RX supplement is also reported to improve male sexual performance. Users report improved erectile function, a decrease in premature ejaculation, low libido and other symptoms of sexual dysfunction. Again, vasodilation seems to be the primary action here.
The primary cause of not being able to get an erection is not enough blood being able to enter into the two tubular structures that form the shaft of the penis (corpus cavernosum). When taking Cissus quadrangularis, more blood flows to the corpus cavernosum, and erections are easier to achieve.
CQ is also being researched for its potential to stimulate sexual desire. Many popular sexual enhancement drugs, like Viagra and Cialis for example, can help induce erections, but do nothing to promote a healthy sexual appetite.
The natural phytonutrient chemicals in CQ are believed to have aphrodisiac properties and to improve the ability to perform vigorously during sex. CQ is also being tested for its capacity to improve spermatogenesis (the synthesis of sperm calls).
More Benefits of Super Cissus RX
Traditional uses of Cissus quadrangularis center around the benefits of this extract for joint and bone health.
It has been used in clinical trials to improve the healing time for fractures and it exhibits analgesic (pain relieving) properties.
Studies have found that taking CQ can improve bone thickness and it has an anti-osteoporotic effect (preventing or slowing the progression of osteoporosis).
It is also observed to simulate collagen synthesis which is known to increase joint motion range and decrease joint pain.
In laboratory studies, it has been found to reduce inflammation, due to the presence of ascorbic acid. It also exhibits an antioxidant effect and shows liver protecting properties.
Another popular reason to take Super Cissus RX is to promote weight loss and a reduction in body fat. In human trials, a standardized extract of Cissus known as CQR-300 was found to improve lipid profiles over the course of the study.
After administering two daily doses of 300mg CQR, total cholesterol levels were reduced, bad LDL cholesterol was reduced and good HDL cholesterol was increased.
The study also shows that Cissus can suppress the appetite, which may be the result of increased Serotonin and Creatinine levels in the blood. Other studies have found that Cissus inhibits amylase and lipase activity, reducing the absorption of fats and carbohydrates from food we eat.
Multiple studies have demonstrated that taking Cissus can reduce total body weight, body fat composition, and waist circumference. It may also improve glycemic control, thereby reducing risk factors for insulin resistance and metabolic syndrome.
The research on Cissus quadrangularis is very promising, however more research still needs to be done, especially larger-scale human trials, as a large portion of the research that has been done was done on animal models. At this time Cissus is available in the US as a supplement only, and the FDA has not approved Cissus quadrangularis as a drug to prevent or treat any conditions.
Super Cissus RX Dosages and Side Effects
Super Cissus RX is marketed primarily to promote healthy joints, ligaments, tendons, cartilage and muscle. USP Labs recommends a dosage of 1600 mg of Super Cissus RX, amounting to two capsules per serving. In clinical trials, this supplement is typically administered 30 minutes prior to meals to block the absorption of fats and carbohydrates.
Cissus quadrangularis supplementation is known to be generally safe for most people. In research trials, it has been determined that this product may be safely used for up to 8 weeks. However, improper and/or excessive use may cause bloating, nausea, headaches, and other mild side effects.
This supplement may interact with anti-diabetes drugs to cause a reduction in fasting blood glucose levels. It could interact with other supplements that reduce blood sugar as well, including Pycnogenol, alpha-lipoic acid, chromium, Panax ginseng, Siberian ginseng and others that have a hypoglycemic effect. Please talk to your doctor before beginning Super Cissus RX supplementation to determine the right dosage and usage of this supplement.
Article last updated on: May 5th, 2018 by Nootriment