Thisilyn Cleanse is produced by supplement company Nature’s Way. This detoxification protocol contains a proprietary form of silymarin extract from the milk thistle plant.
This herbal remedy has been used for hundreds of years to promote liver health, immune function, normal digestion and general well-being.
There are two primary Thisilyn Cleanse kits: Thisilyn Cleanse (Mineral) and Thisilyn Cleanse (Herbal). Both products are prolonged cleanses with a duration of 15 days.
Each kit contains products for three phases: whole body detox, 6-fiber blend and digestive sweep.
The mineral and herbal versions of Thisilyn Cleanse differ in the third phase or digestive sweep: the herbal formulation uses cascasra sagrada, an herbal product derived from the bark of Rhamnus purshianus while the mineral cleanse uses magnesium hydroxide.
Nature’s Way advises beginning all three formulas on the same day and drinking plenty of water throughout the process.
What are the benefits of the Thisilyn Cleanse products and how does milk thistle extract promote liver function and detox?



- Supports liver health & detox
- Anti-oxidant & anti-inflammatory properties
- Improves insulin sensitivity & cholesterol
Thisilyn Cleanse Review
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Many opt to undertake cleanses to support liver function and improve digestion. The liver is responsible for filtering the body’s blood and, when it is functioning properly, can filter the vast majority of toxins, bacteria and heavy metals. The liver also produces bile that helps with digestion.
On its website, Nature’s Way notes that “some experts recommend an internal cleanse 3 to 4 times a year to remove impurities and restore balance.” [1]
Consumer reviews of Thisilyn Cleanse products are generally positive, but users note that the process does require taking many pills over the course of the cleanse (up to 11 capsules a day).
Phase 1: Whole Body Detox
Both the herbal and mineral Thisilyn Cleanse products involve a whole body detox. During this 15-day phase, users are instructed to take one capsule in the morning and one in the evening. [1, 2]
Each capsule contains the following ingredients:
- 173 mg of Urinary Tract Proprietary Blend (cranberry fruit, 90 % concentrate, parsley leaf)
- 130 mg of Lymph, Blood & Skin Proprietary Blend (burdock root, red clover flower, cleaver herb and Oregon grape root)
- 125 mg Thisilyn Milk Thistle extract (from the milk thistle seed, standardized to contain 80 % silymarin)
- 75 mg artichoke leaf extract
- 75 mg turmeric root extract (standardized to contain 95% curcuminoids)
- 40 mg dandelion root
Thisilyn is a proprietary milk thistle extract produced by Nature’s Way. It is used in a number of the company’s products and is standardized to contain 80 % silymarin.
Silymarin is a flavonoid complex composed of three different flavonoids: silibinin, silidianin and silicritsin. This complex is concentrated in the seeds of the milk thistle plant (Silybum marianum), a plant that has been used for millennia in the treatment of liver and gallbladder disorders.
Contemporary research indicates silymarin possesses antioxidant and anti-inflammatory properties and hepatoprotective (liver protecting) effects. In particular, it may help prevent liver damage and support the growth of new liver cells.
Many of the remaining ingredients in the detox supplement are connected with liver function or bile production. For instance, in animal studies dandelion root has been observed to affect liver enzyme levels, like increasing the levels of the “detoxifying” liver enzyme UDP-glucoronosyl transferase. [3]
Turmeric is an antioxidant and anti-inflammatory herb that is commonly used to support digestion and increase bile production by the gallbladder. Artichoke is used to support the flow of bile from the liver to the gallbladder.
Phase II: 6-Fiber Blend
The second phase of the cleanse also lasts 15 days and involves taking three capsules twice a day with at least 8 oz of water.
The capsules contain six fiber sources, including psyllium husk, flaxseed fiber, acacia gum fiber, grapefruit pectin, guar gum and fructooligiosaccharides.
In total, each capsule contains 1 g of dietary fiber. Thus, in Phase II each individual will consume 6 g of additional dietary fiber.
The benefits of a high-fiber diet are well established. A high-fiber diet helps maintain bowel health, control cholesterol and blood sugar levels and achieve a healthy weight. For instance, the Institute of Medicine recommends that women consume 25 g of fiber a day and men 38 g (for individuals 50 and younger). [4]
Phase III: Digestive Sweep
The third phase of the Thisilyn Cleanse is where the mineral and herbal varieties differ. Thisilyn Cleanse (Herbal) contains:
- 850 mg cascara sagrada
- 300 mg Soothing Proprietary Blend (peppermint leaf, ginger root, fennel seed and marshmellow root)
- 270 mg of Triphala Proprietary Extract Blend (a fruit blend standardized to 40 % tannins)
- 190 mg Thisilyn Milk Thistle extract
The main ingredient in the herbal cleanse is cascara sagrada, which is obtained from the dried bark of the plant Rhamnus purshianus. This plant is used medicinally but is also poisonous.
Cascara is produced by aging the shrub’s bark for at least a year because the raw bark is too strong a laxative to be safely used. The active components of cascara are called antraquinones.
These compounds are inactive until they reach the colon, where they cause the softening and forming of stools and vigorous peristalsis (the constriction and relaxation of the colon). [5]
Cascara is commonly used as a laxative but has also been historically used for gallstones and liver ailments.
Nature’s Way recommends users take 2 – 3 capsules at bedtime for no more than 10 days.
Thisilyn Cleanse Mineral Blend
Thisilyn Cleanse (Mineral) contains magnesium hydroxide instead of cascara. Various forms of magnesium, such as magnesium hydroxide, are used to treat constipation.
Nature’s Way notes that magnesium helps clear the bowel in a non-stimulating way, as opposed to peristalsis caused by cascara. The company describes the mineral form as the gentler alternative.
Users are advised to take 3 tablets before bed for 8 days, followed by 2 tablets before bed for an additional 7 days.
Thisilyn Cleanse Side Effects
User reports indicate that Thisilyn Cleanse may cause bloating, gas and other adverse reactions, but that it is generally well tolerated by otherwise healthy individuals.
However, both the herbal and mineral cleanses contain many ingredients that each carry risks of different side effects and drug interactions. Also, because the mixtures are designed to target the liver, gallbladder, bladder and digestive tract, they may aggravate pre-existing health conditions.
Speak with your doctor before undertaking a Thisilyn Cleanse to make sure the product is right for you.
- Nature's Way Product Catalog: Thisilyn Mineral Cleansing Kit. Accessed 25 Jan 2016
- Nature's Way Product Catalog: Thisilyn Herbal Cleansing Kit. Accessed 25 Jan 2016
- Dandelion: Professional Monograph. Natural Medicines Therapeutic Research. Reviewed 3 Apr 2014. Updated 11 Oct 2015. Accessed 25 Jan 2016.
- Mayo Clinic. Fiber: Daily recommendations for adults. Healthy Lifestyle: Nutrition and healthy eating. Accessed 25 Jan 2016
- Cascara: Professional Monograph. Natural Medicines Therapeutic Research. Reviewed 10 Feb 2013. Updated 5 Mar 2015. Accessed 25 Jan 2016.
Article last updated on: April 6th, 2018 by Nootriment