They’re good for your memory, mood, helps fight against depression and naturally improves brain energy. Uridine and choline are brain-boosting supplements that occur naturally in the body as RNA and neurotransmitters, respectively.
Many of us may not get enough of these nutrients through diet and lifestyle alone. Therefore, supplementing with uridine and choline may help slow down the process of brain degeneration and help maintain cognitive functions.
As we age we are all going to be faced with our bodies deteriorating including the degeneration of our muscles, bone and cognitive functions such as memory. Memory loss, at the beginning, often starts with a slow progression of forgetfulness leading into severe degenerations causing conditions like Alzheimer’s and dementia. There is a massive amount of research looking into slowing down the process of aging in order to slow down the development of brain ailments.



- Increases dopamine & choline in the brain
- Supports cognition, memory & mood
- Protects the brain & promotes synapse growth
Benefits of Uridine and Choline
Table of Contents
- What is Uridine?
- Effects and Benefits
- Uridine for Depression
- Risk of Side Effects
- Using Uridine Supplements
- Buy Uridine
- What is Choline?
- What is Acetylcholine?
- Cholinergic Receptors
- Choline's Role in the Brain
- Using Choline Supplements
- Cholinesterase Inhibitors
- Effects and Benefits
- Recommended Dosages
- Dietary Sources
- Choline Rich Foods
Discoveries are being made everyday that show the decline of brain functioning is not inevitable and is, in large part, due to decreasing levels of important compounds in the body that work everyday to protect and regenerate brain tissue.
Uridine and acetylcholine are two of these compounds that help protect the brain and keep it running optimally.
Uridine is a building block of the DNA messenger chemical known as RNA. Ribonucleic acid (RNA) works constantly to rebuild tissue by reading DNA, replicating cells and breaking down aged cells before they have a chance to wreak havoc on the body.
Uridine is therefore vitally important for the development and maintenance of the brain. It helps to protect neuroplasticity and may reduce signs of aging that can lead to impairments in cognitive function. Because it can support healthy brain development, it is also a required fortification ingredient in infant formula in Canada and the USA.
Choline is also closely linked to brain health and mental performance. It is the precursor for the neurotransmitter acetylcholine, which is involved in memory storage and retrieval as well as consciousness and alertness. It is also a major component of cell membranes within the brain and helps to ensure our cells are functioning as they should be.
By increasing intake of choline, we may be able to both keep brain cells healthy and boost performance in critical areas of cognitive performance. There is also evidence showing that using choline and uridine together raises acetylcholine levels to a greater degree than if you were to use these compounds separately.



- Supports memory and synaptic plasticity
- Raises acetylcholine levels
- Promotes brain health and focus
Supporting the Regenerative Process
There are three important processes that regenerate the body: sleep; the breakdown of aged cells; and the removal of harmful substances. When we are lying horizontally, the body is better able to pump circulatory fluid up to the brain to refresh spinal fluid.
This delivers key nutrients and removes waste products that can build up. It also replenishes levels of neurotransmitters and allows our body time to perform important maintenance tasks. This is one reason why we wake up in the morning feeling refreshed.
During the day, waste products begin to build up in the brain again and levels of important neurochemicals can be diminished. We also experience oxidative damage and other types of micro-impairments can develop in our cells. This is a natural result of all of the neurotransmission occurring in the central nervous system. Over time, if this damage is not addressed, it can result in a decrease in the physical health of brain cells and eventual in our mental capacities.
We need to provide our brains with sufficient levels of uridine and choline to support the maintenance processes that are necessary on a day-to-day basis. If excessive damage occurs, it can deplete our stores of these compounds and result in an acceleration of the aging process.
By taking a daily preventative supplement, it may be possible to reduce this type of damage and keep brain cells healthy well into retirement.
How to Take Choline with Uridine
If you are concerned about the possible onset of brain degenerative conditions such as dementia and Alzheimer’s, nootropics such as uridine and choline may be an option to help you take control of your brain health.
Some companies that sell uridine supplements are Absorb Health, Jarrow Formulas and Cardiovascular Research Ltd. Supplements typically range from dosage amounts of 25-250 mg of uridine per capsule. The recommended dose of uridine is 500-1000 mg per day, taken in 250 mg increments.
The recommended dosage of choline will vary according to your individual needs. Adults may consume between 425 and 550 mg per day. If pregnant or nursing, women should be taking more to promote healthy brain function in their babies. Amounts between 400 and 600 mg of choline per day may be recommended for pregnant and nursing mothers.
Dosages can be taken all at once early in the morning or twice a day with a second tablet in the early afternoon. You should not be taking choline later in the day since this can make it difficult to fall asleep at night.
Uridine and choline supplements are likely safe for moderate use. However, recommended doses should be followed and always taken with plenty of water to decrease possible gastrointestinal side effects.
Uridine and Choline Review
Using uridine and choline supplements can be a great way to ensure the body is getting enough of these compounds to maintain a healthy brain. While we cannot eliminate all forms of damage that effect the brain, we can give it the nutrients it needs to fight off premature aging.
These supplements have also been linked to improvements in memory performance and focus, meaning they may be able to enhance your mental performance in the short-term as well. Ensure your diet and supplement regimen is providing you with sufficient levels of molecules like uridine and choline to help keep the brain strong and safeguard it against daily stressors.
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Article last updated on: May 13th, 2018 by Nootriment