Can a daily dose of Uridine powder really be the answer to keeping our brains healthy and vibrant as we age? The answer may be yes.
This naturally forming nucleoside is found in our own bodies and serves vital gene management functions as a part of RNA. It is also found in many of the foods we eat, like beets, sardines, sugar cane, and brewer’s yeast.
Uridine plays a vital role in brain tissue vitality, leading researchers to believe it could have far-reaching impact in the fight against cell death and several neurological disorders, like Alzheimer’s.
Powdered Uridine, the form most often used for supplementation, could be a powerful new method for people to positively support their own brain chemistry. Read on to find out how.



- Increases dopamine & choline in the brain
- Supports cognition, memory & mood
- Protects the brain & promotes synapse growth
Uridine and RNA
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Ribonucleic acid (RNA) is one of the nucleic acids which form the basis of all living, biological structures, including our bodies.
The role of this microscopic molecule is to manage the genetic code of a living creature, delivering information between proteins and DNA.
This governs everything about us – what we look like, how well our organs function, and how our brains are structured to think, learn, and remember. Uridine is one of four nucleosides that comprise RNA, and though it occurs naturally in our systems, it is possible for Uridine levels to go out of balance or be depleted.
RNA also plays a huge part in cognition and memory, by managing and nurturing the growth cycle of connections between neurons. These connections, called synapses, are how we create logical associations between experiences.
You might call this intelligence – but it has a physical base which is shepherded by RNA. When Uridine levels drop in the body, RNA’s ability to foster this growth-positive neural environment is substantially weakened. Taking Uridine powder as a supplement can replenish these levels and allow RNA to do its job.
Uridine further supports synaptic health by synthesizing Phosphatidylcholine (PC) and converting into CDP Choline once inside the brain.Uridine allows for these substances to cross the blood brain barrier and get to work enhancing neural plasticity, helping neurons grow and synaptogenesis to increase. This means more and more information can be passed among growing neurons.
Immediate Effects of Uridine Powder
In addition to these structural changes to brain tissue, Uridine powder also creates several effects that users can consciously feel almost immediately. With daily use, Uridine supplements can improve short and long term memory.
Problem solving skills and reaction time to stimulus will improve. “Brain fog” is banished, replaced with a clear-headed feeling, with easily flowing thoughts. Uridine has been found to aid sensations of procrastination and writer’s block, providing natural mental energy.
Mood is often also enhanced by the powder, as Uridine also encourages the release of dopamine, a neurochemical associated with feelings of happiness and pleasure.
Long Term Benefits of Uridine
In the long term, Uridine may be a viable therapy for more serious neurological disorders, like clinical depression, bipolar disorder, and OCD. It alleviates symptoms of these conditions by enhancing mood and fostering greater mental clarity.
Scientists hope that Uridine’s ability to protect and nurture synaptic health will be part of the solution to the brain’s aging issues. The hardening of neural pathways and decay of synaptic growth are the key causes of disorders like Alzheimer’s disease.
There is no reason that this has to happen as we age. Balancing of neurochemicals through the use of nootropics could be the answer we’ve been looking for in the fight against aging-related decay.
Uridine and Memory
Uridine powder promotes brain plasticity and supports brain cellular health, making the synaptic connections responsible for memory possible. It also participates in a process known as Long Term Potentiation which is how our brain stores and encodes new memories.
Uridine joins forces with and potentiates the effects of choline already present in the brain to produce long term signal strength between neurons. These enduring connections are the heart of long term memories.
How to Take Uridine Powder
Uridine supplements are rarely taken on their own. It is known to stack very well with any other cholinergic, like Citicoline, Acetyl L-Carnitine and Alpha GPC, among others.
Uridine harmonizes with these choline boosters to produce more Acetylcholine in the brain, a plasticity powerhouse which is the source of many nootropic effects.
These include enhanced memory, razor sharp thoughts, and confident, stress-free mood enhancement. Uridine is also known to mix well with DHA and choline. This combination produces more of the vital neurochemical phosphatydlcholine.
If you are able to find Uridine powder for sale as an individual supplement, the recommended dosage generally falls between 1 and 2 grams per person, per day. The more choline-producing supplements you stack it with, the lower the overall dose needs to be, as many of the same effects that Uridine generates are also created by all cholinergics.
If you are unsure about dosing, it’s always best to start with a baseline dose, which in the case of Uridine would be .5 grams. Then simply set about regular daily tasks and note your mental performance, gradually adding to your dose over days or weeks until you feel the desired effects.
- Ulus IH, Watkins CJ, Cansev M, Wurtman RJ. Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release. Cell Mol Neurobiol. 2006
- Wurtman RJ, Regan M, Ulus I, Yu L. Effect of oral CDP-choline on plasma choline and uridine levels in humans. Biochem Pharmacol. 2000
- Walker UA, Langmann P, Miehle N, Zilly M, Klinker H, Petschner F. Beneficial effects of oral uridine in mitochondrial toxicity. AIDS. 2004
Article last updated on: March 20th, 2018 by Nootriment