Oxiracetam is a nootropic substance (from the Greek, meaning ‘mind-turning’) that is believed to help improve cognitive functioning. It is a water-soluble analogue of Piracetam, the original nootropic drug.
This compund, along with all the members of the nootropic family help to modulate, or change slightly, the actions of key neurotransmitters within the brain. This modulation is what leads to the reported benefits of the substance.
Oxiracetam is safe and unlike stimulants is purported to promote neurological health while combating the aging process in your brain.
Exactly what are the benefits of this nootropic and how does Oxiracetam Powder work? There is limited research available on the effects of this smart drug in human and most of the evidence for its effects comes from animal studies.
Many user reviews have indicated that Oxiracetam helps them to think better, especially in the areas of logic, mathematics and analytical topics.
As acetylcholine and glutamate (key neurotransmitters involved in memory and focus) receptors are modulated, cognitive functioning is enhanced.
Some people can experience a significant change, while others report only feeling a slight enhancement. Others say they do not experience any positive effects from this nootropic agent and that it causes side effects like anxiety and irritability.



- Heightens focus, alertness & perception
- Promotes analytical thinking & memory
- Boosts energy & reduces mental fatigue
Oxiracetam Effects
Related Topics
- What is Oxiracetam?
- Dosage Guide
- Reviews
- Oxiracetam Effects
- Side Effects & Safety
- Experience Reports
- Where to Purchase
- Is Oxiracetam Legal?
- Best Oxiracetam Stacks
- Using Oxiracetam Capsules
- Oxiracetam Choline Stack
- Oxiracetam Piracetam Stack
- Aniracetam Oxiracetam Stack
- Pramiracetam Comparison
- Noopept Comparison
- Aniracetam Comparison
Oxiracetam is a nootropic drug that works by increasing activity in excitatory neurotransmitter systems related to memory and thinking.
This supplement also appears to stimulate the central nervous system slightly and has a positive effect on mental energy and clarity.
It is reported to be stronger than the original nootropic Piracetam and requires a lower dosage. However, it is not as powerful as other related compounds like Phenylpiracetam or Noopept.
Oxiracetam was the third racetam nootropic developed following the synthesis of Piracetam. While it was used clinically in some countries under the names Neuracetam and Neuromed, it has not bee used as extensively as other nootropic agents.
One common report from Oxiracetam users is that its CNS stimulation leads to feelings of increased motivation. This may also help to speed up thought processing and may even be helpful in overcoming a lack of sleep.
It has been recommended as beneficial for truck drivers and other people who work long hours and may suffer from an occasional lack of sleep.
Another particularly noticeable effect of Oxiracetam is increased sensory perception. However, this works a bit differently than in some of the other nootropics.
Unlike other family members, this supplement seems to have a much more pronounced effect on hearing and sound. Many users report that they notice all of the different elements which go into sound when listening to music. Treble seems to be especially affected in most cases.
The increased sensory perception is likely linked to increases in cholinergic neurotransmission.
Oxiracetam Benefits
Structurally, Oxiracetam is very similar to Piracetam except for the addition of a hydroxyl group in its pyridionine core. This makes it more bioavailable, which is why a smaller dose is used.
The majority of the effects of this racetam nootropic are similar to those experienced when taking Piracetam. However, there are some key differences.
One important difference is that Oxiracetam has a longer half-life, especially in comparison to its cousin Aniracetam. Users will often take one dose a day instead of the 2-4 doses that someone might consume with Aniracetam.
Many users take Oxiracetam supplements as a study aid, especially when dealing with logic-based subject like math or engineering. Users have described it as making their coursework easier to understand and helping to improve their stamina for mentally taxing tasks.
Users can become tolerant to the effects of Oxiracetam over time. It is best to use it only on certain occasions to prevent the stimulant effects from wearing off.

- Heightens focus, alertness and perception
- Promotes better analytical thinking and memory
- Boosts energy and reduces mental fatigue
Memory and Cognition
Like other Racetam nootropics, Oxiracetam has been studied for its ability to support memory and cognition. It increases stimulation of AMPA receptors for the glutamatergic neurotransmitter system.
These receptors play a role in a process known as Long-Term Potentiation, which is how memories are encoded and stored in our brain. By supporting this encoding pathway, Oxiracetam may be able to enhance long-term memory function, especially in individuals who have been diagnosed with some form of cognitive deficit.
This nootropic has been shown to increase signalling between neurons in the hippocampus, which is involved in memory consolidation, recall and processing.
Oxiracetam also helps to mediate reasoning ability, leaning and attentional control by making receptors for the neurotransmitter acetylcholine more sensitive. It appears to increase the synthesis of this neurotransmitter as well.
Other results include clearer thinking and an improved ability to focus. Alertness and concentration are also enhanced, as is mental energy.
Some users suggest that Oxiracetam has a mood-enhancing effect, but it is not clear what the mechanism for this is. The related nootropic Aniracetam has been shown to increase dopamine and serotonin concentrations, but Oxiracetam does not have this same effect.
It is important to note that most of the research data we have for Oxiracetam comes from rodent studies and there have not been any studies examining its benefits in healthy adults for cognitive enhancement. More research is needed to understand how it impacts cognition under normal circumstances.

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Potential Side Effects
Some users experience mild or temporary side effects when taking Oxiracetam capsules or powder.
In some cases people have reported difficulty sleeping while taking Oxiracetam. It may make it harder to fall asleep at night or may cause your sleep quality to be impaired.
Another reported side effect is having an upset stomach, diarrhea, or nausea. Other people may find that it causes them to become agitated, restless, nervous, anxious or unfocused.
Side effects are more likely to occur at high dosages and during the first week or two of use. Taking a lower dose during the initial period of use can mitigate many of these side effects.
A number of individuals report headaches when they first take Oxiracetam. You can supplement your nootropic stack with a source of choline (the precursor to acetylcholine) if this happens to you.
Taking choline in the form of Alpha GPC or Citicoline can ensure there is enough of this nutrient available in the brain to synthesize acetylcholine. Because Oxiracetam increases HACU (High-Affinity Choline Uptake), it is theorized that not having enough of this nutrient in the brain can lead to headaches.
The generally recommended daily dose of Oxiracetam is between 800 and 2400 milligrams per day. This can be taken either all at once or separated out into two doses.
Because Oxiracetam powder has a long half-life, the dosage should be taken early in the day to avoid insomnia or related side effects.
Always start with a low dose to gauge how you respond to this nootropic drug. While many people do take Oxiracetam in a stack with other supplements, it is recommended to use it on its own first before you begin stacking with smart drugs or natural brain boosters.
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Article last updated on: March 13th, 2018 by Nootriment