Yohimbe supplements are used commonly in alternative medicine to treat a range of ailments, from dry mouth to sexual dysfunction. Although these supplements offer a number of benefits, they are not appropriate for everyone and side effects are possible.
Yohimbe is an an herbal extract. derived from the bark of the Pausinystalia yohimbe tree. This tree grows in the western part of Africa and has a long history of use as a natural remedy.
Yohimbe supplements contain an active ingredient known as “yohimbine” – an alpha-2 adrenoceptor antagonist. This chemical has a stimulatory effect on the body, promoting blood flow to the genitals and boosting fat metabolism.
There is evidence that yohimbe can improve sexual health and support enhanced sex drive in men and women. The supplement may also promote fat loss, but it should be used under medical supervision to reduce the risk of adverse effects.



- Helps promote fat loss
- Increases energy & suppresses appetite
- Promotes sex drive & performance
Yohimbe Supplements
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Yohimbe supplements work by inhibiting the effects of alpha-2 adrenergic receptors in the peripheral nervous system.
Because alpha-2 adrenoceptors are present in a multitude of locations all throughout the body, yohimbe can have many profound effects on bodily functions. Some of the effects of yohimbe on the body include:
- Increased noradrenaline release
- Increased norepinephrine release
- Anti-diuretic effects
- Increased reflex excitability in the sacral region of the spinal cord
- Inhibition of platelet coagulation
Yohimbe supplements are available in the form of pills and powders. Pills are swallowed with water, while powders are typically mixed with drinks.
It is also possible to make a yohimbe tea using ground bark or tea bags purchased from a retailer.
All of these methods of consumption will provide you with a dose of yohimbine alkaloids, but the exact amount contained in each dose will vary.
Yohimbe Extract Uses and Dosages
Yohimbe extract has been research for its effects on a number of health conditions. Yohimbine HCL is sold as a prescription medication in the United States, although it is no longer widely used.
Some of the common uses for yohimbine include anxiety, depression, orthostatic hypotension, sexual dysfunction, erectile dysfunction and dry mouth.
Yohimbe supplements may also be used to improve athletic or exercise performance, increase sexual arousal and improve orgasms.
The recommended dosage of yohimbine, the active ingredient in yohimbe, depends on the patient’s intended usage. General dosing guidelines for yohimbine are detailed below.
Note that the dosages listed below are based on the doses used in clinical trials. The optimal dose for your needs may be different. It is important to check with a doctor to determine the correct, safe dose of this supplement for you.
- Anxiety: To treat anxiety, 10 mg of yohimbine once weekly has been used. This works best when the supplement is used in combination with psychotherapy.
- Depression: To reduce the symptoms of depression, 5 to 30 mg of yohimbine daily has been used.
- Orthostatic hypotension: To treat orthostatic hypotension, 5.4 mg of yohimbine extract has been administered.
- Sexual dysfunction: To improve the symptoms of sexual dysfunction, 15 to 18 mg of yohimbine has been used for short periods of time.
- Erectile dysfunction: For erectile dysfunction, doses of between 5 to 100 mg daily have been studied. The supplement has been administered in up to 4 divided doses .
- Athletic performance: To improve athletic or exercise performance, doses of 20 mg of yohimbine twice daily have been used.
- Sexual Arousal/ Orgasm improvement: To improve arousal and orgasms, between 20 to 50 mg of yohimbine has been taken daily in divided doses.
Keep in mind that yohimbe supplements may contain varying amounts of yohimbine alkaloids. It is important to purchase your supplements from companies that provide a standardized yohimbe extract.
Many of the side effects related to the consumption of yohimbe become more serious with higher dosages. You should never take more of the supplement than you need to achieve the result you desire.
Always talk to a doctor before beginning to use a yohimbe supplement for any reason. Start with a low dose of this product and gradually work your way to the lowest effective dosage.
Yohimbe Supplement Side Effects
The benefits of yohimbe supplements are well established. Unfortunately, these supplements may also cause serious side effects, especially when they are not taken correctly.
To avoid side effects, take this supplement as directed by your doctor and avoid any substances known to interact with yohimbe. Substances that may interact with yohimbe include:
Certain medications: Avoid stimulants, tricyclic antidepressants, nalaxone, phenothiazines, guanabenz and monoamine oxidase inhibitors.
Other supplements: Avoid supplements containing caffeine or ephedra, as well as berberine and anticoagulant supplements.
Certain foods: Avoid foods containing vasopressors, such as chocolate, coffee, tea and soda. Also avoid foods containing tyramine, including aged cheese, red wine and fermented meat.
Some of the possible side effects of yohimbe supplements include changes in blood pressure, respiratory depression, myocardial infarction, cardiac arrhythmias, agitation and seizures.
If you notice any of these potentially serious side effects, seek immediate medical attention.
Yohimbe Supplement Contraindications
If you have any of the following conditions, do not take yohimbe supplements unless directed to do so by your doctor.
- Schizophrenia
- Post-traumatic stress disorder
- Liver disease
- Depression
- Bleeding conditions
- Benign prostatic hyperplasia
- Anxiety
- Kidney disease
- Hypotension
- Hypertension
- Diabetes
- Angina
- Heart disease
Yohimbe is not suitable for children or infants. Do not take yohimbe if you are pregnant or breastfeeding.
Yohimbe Supplement Brands
Before you buy a yohimbe supplement, it is important to consider your options carefully. Read reviews from past consumers who have used the various supplements you are considering.
You can find yohimbe supplement reviews in the form of testimonials on retailer’s websites, as well as in the form of unbiased reviews on third party sites.
Keep in mind that the concentration of yohimbine in these supplements may vary widely, so don’t assume that all supplements are providing the same value.
- http://www.nature.com/ijir/journal/v14/n1/full/3900803a.html
- https://examine.com/supplements/yohimbine/
- Yohimbe – Natural Medicines Database
Article last updated on: March 12th, 2018 by Nootriment