Yohimbine HCL has received some attention from the nootropic community for its positive effects on energy, mood and concentration.
Yohimbine HCL is considered to be a mild MAO Inhibitor with stimulant and aphrodisiac effects. It is sold in pure form for the treatment of sexual dysfunction and has been explored as a potential treatment for type II diabetes.
As a supplement, this alkaloid is derived from the bark of a West African evergreen tree known as Yohimbe. Yohimbine is an active chemical found within Yohimbe bark extract. In many cases, this supplement is used for treating side effects that may be caused by selective serotonin reuptake inhibitors (SSRIs).
There are reports which indicate this supplement is a powerful fat burning and muscle building compound. It is currently being used in a number of fat loss aids and dietary supplements. There is also a high level of interest in this pre-workout supplement among athletes, who feel that it may have performance enhancing effects.
On the cognitive enhancement side, Yohimbine is sometimes taken by individuals for its energy-boosting qualities. This herbal supplement has been used as a study pill and productivity enhancer because it can increase motivation, focus, mental performance and stamina on demanding tasks. However, as a stimulant, there are several safety concerns and negative side effects associated with Yohimbine HCL.



- Helps promote fat loss
- Increases energy & suppresses appetite
- Promotes sex drive & performance
Yohimbine HCL Effects:
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Medically speaking, this supplement is considered to be a pre-synaptic alpha-2 adrenergic receptor blocking agent or antagonist. What this means is that it tends to increase the activity of the sympathetic nervous system.
This is primarily why the supplement is categorized as a stimulant, since it is also responsible for increasing the release of adrenaline (epinephrine) and norepinephrine in the bloodstream. This part of the nervous system is involved in controlling and regulating the body’s overall response to stress, as well as triggering the fight or flight response.
Normally, you would expect this stimulant response to lead to increased blood pressure and heart rate. However, in low doses, Yohimbine HCL has been observed to have the opposite effects, namely reducing blood pressure. This is thought to be due to an ability to dilate or relax blood vessels.
The temporary widening of blood vessels tends to reduce vascular resistance and make blood flow easier. This dilation effect may have a number of sexual benefits as well, leading to increased circulation to sexual organs.
Yohimbine also works by heightening the fat burning process within the human body. This is likely the result of increased thermogenesis which is associated with higher levels of epinephrine and norepinephrine.
Yohimbine also inhibits a regulatory process that normally limits your natural fat burning rate. The result is a higher metabolism particularly targeting stored lipids or fat deposits which can improve your diet or weight loss results. This action does seem to be partially negated when the supplement is taken with food.
Yohimbine HCL Benefits:
From a nootropic standpoint, the benefits of Yohimbine relate to the energy-boosting effects of this drug. As a stimulant, it will lead to increased alertness, perceptual awareness, reduced brain fog and even raise your motivation levels.
This can have a positive influence on mental performance as it relates to concentration, accuracy in performing tasks, memory, reaction time, and speed of cognitive.
However, Yohimbine does not technically fall under the official definition of a nootropic because its primary mechanism of action is to stimulate your central nervous system. While some people do use it for cognitive enhancement applications, you would be better off taking this sparingly or instead using a nootropic like Aniracetam that has the same positive effects without the stimulant-like side effects.
In terms of other uses, one of the primary benefits of this supplement is as a libido enhancer and for treatment of erectile dysfunction. The reason why this works is likely due to the vasodilation properties of Yohimbine. As the blood vessels are opened and dilated, the smooth muscles tend to also relax.
This allows an improved blood flow, which is the primary requirement for helping to reverse erectile dysfunction. But while many other ED supplements only boost libido in men, Yohimbe extract is observed to have a positive effect on women as well. Many reviews cite the fact that it can be used as a general arousal booster in addition to overcoming ED.
Yohimbine HCL is also used as a fat burning agent or supplement. This is caused by the supplement blocking specific receptors that inhibit fat loss. Some studies have observed that Yohimbine increases the amount of non-esterified fatty acids, which are usually associated as a by-product of fat breaking down.
The increased levels of adrenaline are also helpful in this regard, to speed up the metabolism and increase the amount of fat burning within the body. This natural compound is also used by bodybuilders and athletes to enhance their physical performance, allowing them to work out harder for longer.
Yohimbine HCL Dosage:
There does not seem to be a generally accepted recommended dosage level for this supplement. However, the studies and research indicate that the dose should be more or less dependent upon your reason for taking Yohimbine HCL. As a weight loss supplement, 20 mg per day seems to be reasonably effective. On the other hand, as a possible treatment for erectile dysfunction you might want to use 5 to 10 mg as needed.
When taking a new supplement, particularly an herbal formula like Yohimbine, it is important to begin with the lowest effective dose. Only consider increasing this level once you are thoroughly familiar with the effects, benefits, and even possible side effects. It is also always advisable to consult with a qualified medical professional before starting supplementation.
Yohimbine HCL Side Effects:
When taking in typical doses there are some reported side effects associated with this supplement.
These include stomach upset, excitation, tremor, sleep issues, anxiety or agitation, high blood pressure, rapid heartbeat, dizziness, sinus pain, irritability, headache, frequent urination, bloating, rash, nausea, and vomiting.
When used in high doses, this can cause additional problems, including difficulty breathing, paralysis, very low blood pressure, heart issues, and even death.
There are also a number of conditions in which a person should not use this supplement. Pregnant and breast feeding women should avoid. Those who have schizophrenia and prostate problems should use with caution. If you have PTSD, liver disease, kidney disease, high or low blood pressure, chest pain, heart disease, depression, or diabetes do not use this supplement.
Yohimbine HCL Review:
Yohimbine HCL may have some properties that lead to enhanced mental performance, but there are a number of safety concerns with this supplement. If you are considering using Yohimbine for weight loss or as a sexual performance booster, make sure to speak to a qualified doctor first for advice.
We strongly urge caution when taking any stimulants like Yohimbe bark extract and you should never exceed the suggested dosages for this product. For those interested in potential nootropic benefits of this supplement, there are a number of suitable replacements that can give you the same advantages without the dangerous risks.
You might want to consider Aniracetam, Noopept or Pramiracetam as three potential alternatives. Another option is Modafinil or Adrafinil which have some of the same positive stimulant effects without the negative effects associated with Yohimbine.
Article last updated on: March 17th, 2018 by Nootriment
1 Comment
Side effects do concern me, yet previous use has shown real results in sexual performance. I was mostly concern about the increase in blood pressure and the effects it may have on the kidney.