Review: Zynapse Citicoline 500mg & 1000mg

Zynapse Citicoline is a Nootropic supplement that is used to improve memory, augment learning capacity, enhance general intellect, and increase attention span, focus, and concentration.

The main ingredient in this supplement – CDP Choline – has been widely studied and research has found it to be very safe and effective.

Zynapze Citicoline is most notably a source of Choline which is needed to make an important neurochemical involved in memory and basic thought processes – Actylcholine.

Citicoline also operates to increase the blood flow to the brain along with oxygen uptake and glucose metabolism. It is also thought to help in the biosynthesis of phospholipids and other brain materials.

What is the right way to use Zynapse Citicoline and are there other Citicoline supplements out there that may be a better choice?

Citicoline

Cholinergic Supplement

Memory

Focus

Brain Health

How It Works:

• Supports memory, focus & mental clarity
• Increases levels of acetylcholine neurotransmitter
• Promotes brain cell health & communication

Dosage:

Between 250 - 2,000 mg per day

Safety:

Rated Likely Safe

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Pharmacodynamics of Zynapse Citicoline

Citicoline is a naturally occurring endogenous compound that acts as an intermediary in the biosynthesis of phospholipids, which make up the majority of cell membranes (including neurons).

When this supplement is taken orally it is absorbed almost completely by the body into the bloodstream.

As Citicoline enters the bloodstream, it breaks down into several component substances which are Cytidine and Choline.

They both disperse widely throughout the body and easily cross the blood-brain barrier, reaching the central nervous system. Then, they help in the formation of phospholipids to build new cell membranes for neurons within the brain.

This accelerated replacement and/or repair of neuronal cell membranes has a number of applications including maintaining the healthy function of a numerous physiological and possibly even cognitive processes.

This also leads to increased cerebral metabolism and the increase of a number of neurotransmitters within the brain, especially Acetylcholine and Dopamine. These neurotransmitters are also thought to play significant roles in memory formation, focus, alertness, reasoning, and perception.

Zynapse Citicoline has also been shown to restore the activity of ATP within the mitochondria that may cause an increase in brain energy.

This supplement has also shown some exciting results in clinical uses. Citicoline was originally developed for use in the treatment of stroke survivors. When administered within 24 hours after they have suffered a stroke, patients who received Citicoline were more likely to have a complete recovery after three months than patients given a placebo.

Another study found that 500 mg of intravenous Citicoline within 12 hours of stroke symptoms and then for the 7 days following the stroke improved symptoms when compared to a group not treated with Citicoline.

There have also been great interest recently in using Citicoline as a potential treatment for Alzheimer’s disease, Parkinson’s disease, and even certain forms of age-related dementia. The Natural Medicines database has rated Citicoline as Possibly Effective for improving age-related cognitive impairment. In one study, patients between 50-85 with poor memory given 1000-2000 mg Citicoline daily seemed to improve their verbal memory.

Research on Citicoline has been very promising so far, however more research is still needed. At this time, Citicoline is available as a health supplement only, and the FDA has not approved Citicoline as a drug to prevent or treat any conditions.

Benefits & Uses of Zynapse Citicoline

Despite the many medical applications, most people looking to buy Zynapse Citicoline are interested in some of the off-label cognitive enhancement effects.

Many users have reported that they see increases in memory, speed of recall, and even an expansion of their learning capacity. Citicoline is often used by students looking to get that extra boost they need for studying or taking tests.

Another aspect of these cognitive benefits result from an increased mental energy. This is thought to be a direct result of the greater blood flow, oxygen, and glucose uptake in your brain cells. As mental energy increases it also helps to raise attention span and may result in better productivity and motivation in general.

Some people report that Citicoline also helps them remain awake with fewer signs of fatigue for longer hours and prevents some of the effects of sleep deprivation.

Zynapse Citicoline Dosage

Proper dosage depends on many different factors including age, weight, health status, and the reason for taking a supplement. The dosage recommendations below are general guidelines only, and your dosage may different. It is always recommended that you speak with your doctor to help determine your best personal dosage.

Zynapse Citicoline is available as an injection only. It is administered in 500 mg dosages, either once or twice a day, for a total dosage of between 500-1000 mg.

Other brands as well as generic Citicoline also comes in both 500mg and 1,000mg capsules. For most people, the proper dose will be a single capsule each day. You can take Citicoline either with or without food.

Many people prefer to take Citicoline early in the morning as taking it too late in the day may lead to insomnia. This is due to some of the mild stimulant effects of the supplement which are excellent for daytime use but can cause restlessness in the evening.

Unless instructed otherwise by your doctor, it is recommended that you start at the lower dose and only increase as needed. If you plan to take 1,000mg per day, it might be a good idea to split it into 2 doses, one in the morning and the other with lunch.

Possible Side Effects & Contraindications

There are a few side effects reported with Zynapse Citicoline. These are generally very mild and uncommon.

They include headaches, fatigue, nausea, diarrhea, and other intestinal issues. In very rare occasions there might be dizziness and a reduction in blood pressure associated with larger Citiciline dosages.

There are no known direct contraindications for Zynapse Citioline, although it is not advisable for pregnant or nursing women to take this, since there is not enough data to make a determination for safety at this time.

Zynapse Citicoline Review

Citicoline is a powerful nootropic by itself, but its effects are significantly amplified when used in conjunction with other nootropics in a stack.

The best Citicoline stacks typically involve Racetams like Piracetam, Pramiracetam, Aniracetam or Noopept. These supplements use complimentary mechanisms of action to Citicoline making them a natural pairing.

Another factor which you should consider before buying Zynapse Citicoline is cost. This is one of the most expensive brand names for Citicoline because it is administered as an injection rather than a tablet or powder format.

If you want to purchase Citicoline for ongoing nootropic supplementation, buying it in bulk powder format can save you a lot of money.

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